Results 71 to 80 of about 16,081,069 (297)

The association between sleep problems, learning disabilities and substance use in adolescence [PDF]

, 2007
Includes bibliographical references (leaves 90-112)The current study focused on investigating the relationship between sleep problems, learning disabilities and substance use in adolescence.
Fakier, Nuraan
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

OTHER TITLES: Substance Use Disorders Task Force meeting outcomes: characterization of recommendations: provider education recommendations. Provider education recommendations

, 2018
I. Centralize Coordination of Substance Use Disorder Policy and Provider Education -- II. Provide additional education in training programs for healthcare professionals -- III. Develop and disseminate materials on K-TRACS and CDC Guidelines to healthcare
Kansas. Governor's Substance Use Disorders Task Force.
core   +1 more source

Models of Concurrent Disorder Service: Policy, Coordination, and Access to Care

Frontiers in Psychiatry, 2019
Background: Societal capacity to address the service needs of persons with concurrent mental health and substance-use disorders has historically been challenging given a traditionally siloed approach to mental health and substance-use care.
Mary Wiktorowicz, Aber Abdulle, Kaitlin Di Pierdomenico, Sheila A. Boamah   +3 more
doaj   +1 more source

Substance Use Disorders in ADHD: A Multimodal Approach

, 2022
Attention Deficit Hyperactivity Disorder (ADHD) is today one of the most relevant disorders in the clinical setting, not only because of its prevalence but also because of its high comorbidity with other diseases. Its peculiar characteristics undoubtedly
De la Serna Tuya, Juan Moisés, Altable, Marcos, Diaz, Emilio, Srifi Hasnaoui, Adnan   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Caffeine and Substance Use Disorders [PDF]

Journal of Caffeine Research, 2013
Caffeine is the most consumed psychoactive drug in the world. As a psychostimulant, it shows all the pharmacological properties of classical psychostimulants, such as cocaine and amphetamine. Those properties include arousal, motor activation, and reinforcing effects.
openaire   +2 more sources

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

‘They really want to find some kind of box they can put you in’: how young people with severe mental health problems and complex needs talk about their past treatment in traditional child and adolescent mental health services - a critical discourse analysis

Frontiers in Psychiatry
Challenges in child and adolescent mental health services (CAMHS), including complex and fragmented services, are well documented, particularly to young people with severe mental health problems and complex needs.
Marthe Johansen, Ottar Ness, Hanne Kilen Stuen, Eva Brekke, Eva Brekke, Anne Landheim, Anne Landheim   +6 more
doaj   +1 more source