Results 71 to 80 of about 321,265 (263)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Metabolic Syndrome and Associated Risk Factors in Norwegian Trauma-Exposed Inpatients: A Cross-Sectional Comparison with Blood Donors

Diabetes, Metabolic Syndrome and Obesity
Grethe Emilie Roer,1,2 Ingeborg Bolstad,3 Dawit Shawel Abebe,1,2 Jan Aaseth,3,4 Morten Haugen,5,6 Lars Lien1,3 1Research Center for Substance Use Disorders and Mental Illness, Innlandet Hospital Trust, Brumunddal, NO-2381, Norway; 2Department of Nursing ...
Roer GE, Bolstad I, Abebe DS, Aaseth J, Haugen M, Lien L   +5 more
doaj  

Gabapentin for Off-Label Use: Evidence-Based or Cause for Concern?

Substance Abuse: Research and Treatment, 2018
Gabapentin is widely used in the United States for a number of off-label indications, often as an alternative to opioid therapy. Increasing evidence has emerged suggesting that gabapentin may not be as benign as once thought and may be associated with ...
Alyssa M Peckham, Kirk E Evoy, Leslie Ochs, Jordan R Covvey   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Mental health and energy drink consumption among Norwegian adolescents; a cross-sectional study

BMC Public Health
Background Energy drinks (ED) are marketed as boosters of mental and physical health, but few studies have looked at the mental health of adolescents who consume large amounts of ED.
Siri Kaldenbach, Marja Leonhardt, Tor A. Strand, Mads Holten-Andersen   +3 more
doaj   +1 more source

Prevalence of Substance Use and Associated Factors Among Secondary School Students in Marrakech Region, Morocco

Psychoactives
Adolescence is a phase characterized by reckless and risky behaviors, including the initiation and use of various illicit substances such as cannabis and alcohol.
Abdelmounaim Baslam, Samia Boussaa, Karima Raoui, Hamid Kabdy, Abdelfatah Aitbaba, Loubna El Yazouli, Rachida Aboufatima, Abderrahman Chait   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Health Workers’ Perceptions of Suicide Risk Assessments: A Survey Study from Norway

Psychiatry International
Suicide is a serious and global health problem, with important consequences for individuals and for society. Understanding health workers’ perspectives is important for understanding how clinicians think about this topic and their attitudes toward and ...
Martin Bystad, Lars Lien, Sanja Krvavac, Rolf Wynn   +3 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source