Results 91 to 100 of about 16,081,069 (297)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Reasons for substance use among people with mental disorders [PDF]

, 2012
Background:\ud Comorbidity of mental disorders and substance use continues to be a major problem. To inform\ud the development of more effective interventions for these co-existing disorders, this paper aimed to determine\ud if there are clear variations
Kavanagh, David J., Kelly, Brian, Terry J. Lewin, Robyn Richmond, Richmond, Robyn, Brian Kelly, Thornton, Louise K., Martin P. Johnson, Frances J. Kay-Lambkin, Thornton, Louise K, Kavanagh, David, Louise K. Thornton, Kay-Lambkin, Frances, David Kavanagh, Baker, Amanda, Johnson, Martin, Lewin, Terry, Amanda L. Baker   +17 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Metabolic Syndrome and Associated Risk Factors in Norwegian Trauma-Exposed Inpatients: A Cross-Sectional Comparison with Blood Donors

Diabetes, Metabolic Syndrome and Obesity
Grethe Emilie Roer,1,2 Ingeborg Bolstad,3 Dawit Shawel Abebe,1,2 Jan Aaseth,3,4 Morten Haugen,5,6 Lars Lien1,3 1Research Center for Substance Use Disorders and Mental Illness, Innlandet Hospital Trust, Brumunddal, NO-2381, Norway; 2Department of Nursing ...
Roer GE, Bolstad I, Abebe DS, Aaseth J, Haugen M, Lien L   +5 more
doaj  

If you build it, they will stay! Sustaining evidence-based practices for the treatment of substance use disorders through investment in workforce retention

Frontiers in Public Health
Much attention has been paid to the persistent gap between the development of effective, evidence-based practices (EBPs) for substance use disorders (SUDs) and their routine delivery in real-world clinical and community settings.
Michael J. Chaple, Michael J. Chaple, Sara Becker, Thomas E. Freese, Bryan Hartzler, Rosemarie Martin, Todd Molfenter, Beth A. Rutkowski   +7 more
doaj   +1 more source

HIV and Substance Use Disorders

Infectious Disease Clinics of North America
Over 1.2 million Americans aged 13 years and older have been diagnosed with human immunodeficiency virus (HIV). While HIV incidence has been declining since 2017, the risk of HIV acquisition and transmission persists among persons who use drugs via injection drug use and unprotected sexual intercourse associated with substance use.
Lier, Audun J., Tarfa, Adati, Shenoi, Sheela V., Kuo, Irene, Springer, Sandra A.   +4 more
openaire   +3 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Mental health and energy drink consumption among Norwegian adolescents; a cross-sectional study

BMC Public Health
Background Energy drinks (ED) are marketed as boosters of mental and physical health, but few studies have looked at the mental health of adolescents who consume large amounts of ED.
Siri Kaldenbach, Marja Leonhardt, Tor A. Strand, Mads Holten-Andersen   +3 more
doaj   +1 more source

Gabapentin for Off-Label Use: Evidence-Based or Cause for Concern?

Substance Abuse: Research and Treatment, 2018
Gabapentin is widely used in the United States for a number of off-label indications, often as an alternative to opioid therapy. Increasing evidence has emerged suggesting that gabapentin may not be as benign as once thought and may be associated with ...
Alyssa M Peckham, Kirk E Evoy, Leslie Ochs, Jordan R Covvey   +3 more
doaj   +1 more source

Canadian Institute for Substance Use Research Annual Report 2021-2022 [PDF]

, 2022
FacultyUnreviewe
Canadian Institute for Substance Use Research (CISUR)
core