Results 91 to 100 of about 729,288 (289)

Identifying Early Warning Signs: Addressing Youth Substance Use [PDF]

, 2015
Of high school students 35 percent indicate they are current drinkers, 20 percent are binge drinkers, and 24 percent use marijuana. By the time they are seniors more than 20 percent will have used a prescription drug for a nonmedical purpose.

core  

Traumatic Stress Interacts With Bipolar Disorder Genetic Risk to Increase Risk for Suicide Attempts [PDF]

, 2017
Objective Bipolar disorder (BD) is one of the most heritable psychiatric conditions and is associated with high suicide risk. To explore the reasons for this link, this study examined the interaction between traumatic stress and BD polygenic risk ...
Benke, Kelly, Brucksch, Christine, Edenberg, Howard J., Fisher, Carrie, Frankland, Andrew, Fullerton, Janice M., Ghaziuddin, Neera, Glowinski, Anne L., Hulvershorn, Leslie A., Kamali, Masoud, Kastelic, Elizabeth, McInnis, Melvin G., Miller, Leslie, Mitchell, Philip B., Nurnberger, John I., Jr., Roberts, Gloria M. P., Shaw, Alex D., Stapp, Emma K., Toma, Claudio, Wilcox, Holly C.   +19 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Mothering, substance use disorders and intergenerational trauma transmission : an attachment-based perspective [PDF]

, 2019
Background: A growing body of research underlines that interpersonal trauma in childhood leads to heightened susceptibility for substance use disorders (SUDs) in later life.
De Pauw, Sarah, Meulewaeter, Florien, Vanderplasschen, Wouter   +2 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The classification of substance and behavioural addictions: A preliminary investigation [PDF]

, 2012
The term addiction has been used to refer to impaired control over substance use for several centuries however recently there has been a shift toward using this term in the context of non-substance use disorders, such as pathological gambling.
McLaughlan, Andre David, Starkey, Nicola J.   +1 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Treating Young People with Co-Occurring Disorders: What Works? [PDF]

, 2014
Youth with substance use disorders often also face mental health challenges. Two recent studies analyzed two different treatment approaches for co-occurring substance use and mental health disorders: (1) a standardized therapy approach and (2) 12-step ...
Gowen, L. Kris, Kennedy, Molly Oberweiser   +1 more
core   +1 more source

Factors associated with relapse among clients in Australian substance disorder treatment facilities [PDF]

, 2006
Factors associated with relapse to problematic alcohol or illicit drug use were examined in 104 clients enrolled in treatment programmes for substance disorders.
Hammerbacher, Melissa, Lyvers, Michael
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source