Results 51 to 60 of about 137,395 (319)

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Current Concepts on Drug Abuse and Dependence [PDF]

, 2015
Drug addiction is a complex disease characterized by compulsive and uncontrollable desire to seek and consume the drug. In time, drug-related terminology has undergone many changes, arising from the deepening of the mechanisms of action, but also about ...
Baconi, Daniela Luiza, Bălălău, Cristian, Ciobanu, Anne-Marie, Cobani, Oana Denisa, Negrei, Carolina, Vlăsceanu, Ana Maria   +5 more
core   +2 more sources

A protocol for enhancing the diagnostic accuracy and predictive validity of neonatal opioid withdrawal syndrome: The utility of non-invasive clinical markers

PLoS ONE
Every 15 minutes in the US, an infant exposed to opioids is born. Approximately 50% of these newborns will develop Neonatal Opioid Withdrawal Syndrome (NOWS) within 5 days of birth.
Sarah E. Maylott, Barry M Lester, Lydia Brown, Ayla J Castano, Lynne Dansereau, Sheila E. Crowell, Pascal Deboeck, Amy Salisbury, Elisabeth Conradt   +8 more
semanticscholar   +1 more source

Development and Validation of Machine Learning‐Based Marker for Early Detection and Prognosis Stratification of Nonalcoholic Fatty Liver Disease

Advanced Science, EarlyView.
This study constructs a stacked multimodal machine learning model for nonalcoholic fattly liver disease (NAFLD) by integrating genetic and clinical features, and synthesize an in‐silico quantitative marker (ISNLD) that enables personalized risk stratification for intrahepatic and extrahepatic outcomes of high‐risk individuals of NAFLD.
Lushan Xiao, Lin Zeng, Jiaren Wang, Chang Hong, Ziyong Zhang, Chengkai Wu, Hao Cui, Yan Li, Ruining Li, Shengxing Liang, Qijie Deng, Wenyuan Li, Xuejing Zou, Pengcheng Ma, Li Liu   +14 more
wiley   +1 more source

Symptomology Associated with in Utero Exposures to Polysubstance in an Appalachian Population

Marshall Journal of Medicine, 2019
Neonatal abstinence syndrome (NAS) is seen as a very high rate at our institution in Huntington, West Virginia, and the majority of exposures are polysubstance in nature. Polysubstance can have different meaning for each region.
Will Lester, Lacey Andrews, Emma M. Nellhaus, Sara Murray, Sean Loudin, Todd H. Davies   +5 more
doaj   +1 more source

Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals [PDF]

, 2009
Aims: Problem gambling has been proposed to represent a ‘behavioural addiction’ that may provide key insights into vulnerability mechanisms underlying addiction in brains that are not affected by the damaging effects of drugs.
American Psychiatric Association, Bechara, Beck, Berlin, Blaszczynski, Bush, Campbell-Meiklejohn, Cardinal, Cavedini, Clark, Clark, Clark, Clark, Crews, Cunningham-Williams, Cunningham-Williams, Dalley, Dom, Drummond, Evenden, Fein, Fellows, Foster, Fuentes, Goudriaan, Goudriaan, Goudriaan, Griffiths, Kagan, Kubota, Leiserson, Lejuez, Lesieur, Lezak, Mazas, Noel, Orford, Owen, Passetti, Petry, Petry, Petry, Pfefferbaum, Potenza, Potenza, Potenza, Potenza, Roca, Rodriguez-Jimenez, Rogers, Rosenthal, Shaffer, Shaffer, Skinner, Slutske, Sproston, Steel, Stockwell, Sullivan, Tavares, Toneatto, Ussher, Verdejo-Garcia, Vitaro, Wardle, Welte, Wray   +66 more
core   +2 more sources

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Toxidrome-based Approach to Common Poisonings [PDF]

Asia Pacific Journal of Medical Toxicology, 2014
Poisoning remains a major cause of hospital admission into the emergency department and intensive care unit. Proper diagnosis is the cornerstone for optimal management of poisoned patients.
Bruno Mégarbane
doaj  

Inhibitory effects of Echinophora platyloba L. ethanol extract on the development of morphine dependence: An in vivo study using naloxone-precipitated withdrawal symptoms in male mice [PDF]

Jorjani Biomedicine Journal, 2023
Background: Promising results were obtained by using medicinal plants for the treatment and prevention of opioid withdrawal syndrome. A native Iranian plant, Echinophora platyloba, has shown analgesic effects that may be mediated through opioid receptors.
Amir Abbas Barzegari, Ahmad Aghaee, Kamran Shahabi   +2 more
doaj  

Fentanyl versus Methadone in Management of Withdrawal Syndrome in Opioid Addicted Patients; a Pilot Clinical Trial

Archives of Academic Emergency Medicine, 2021
Introduction: The most effective treatment for withdrawal syndrome in Opioid-dependent patients admitted to intensive care units (ICUs) remains unknown. This study aimed to compare fentanyl and methadone in this regard.
Baharak Najafi, Shahin Shadnia, Hossein Hassanian-Moghaddam, Amir Heydarian, Arezou Mahdavinejad, Nasim Zamani   +5 more
doaj   +1 more source