Results 1 to 10 of about 133,054 (344)
Nature Communications, 2020 The substantia nigra is important in neurological disease, particularly movement disorders. Here the authors provide a single cell transcriptomic atlas for the human substantia nigra.
Viola Volpato +2 more
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Substantia nigra and blood gene signatures and biomarkers for Parkinson’s disease from integrated multicenter microarray-based transcriptomic analyses [PDF]
Frontiers in Aging NeuroscienceBackgroundParkinson’s disease (PD) is a complex, common neurodegenerative disorder with unclear etiology. The pathogenic hallmark is the death of dopaminergic neurons in the substantia nigra. PD diagnosis depends on clinical manifestation of symptoms but
Hui-Hui Fan +11 more
doaj +2 more sources
Stable Dopamine-Signaling mRNA Co-Expression in the Substantia Nigra Is Deregulated in Pathological Conditions, but Not in Dopamine Transporter Knockout Rats [PDF]
BiomoleculesDopamine transporter (DAT) mutations are associated with neurological and psychiatric diseases, and DAT gene knockout in rats (DAT-KO) provides an opportunity to evaluate the DAT role in pathological conditions.
Anastasia N. Vaganova +3 more
doaj +2 more sources
Striatal neuroinflammation promotes parkinsonism in rats [PDF]
, 2008 The specific role of neuroinflammation in the pathogenesis of Parkinson's disease remains to be fully elucidated. By infusing lipopolysaccharide (LPS) into the striatum, we investigated the effect of neuroinflammation on the dopamine nigrostriatal ...
Don Gash +9 more
core +21 more sources
Frontiers in Neurology, 2023 ObjectiveThis study aimed to investigate the application value of multi-parametric magnetic resonance imaging (MRI) in the diagnosis of iron deposition in the substantia nigra dense zone in Parkinson's disease (PD) and to evaluate the diagnostic value of
Qing Cao +7 more
doaj +1 more source
PLoS ONE, 2023 Patients with Parkinson's disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson's disease simultaneously
Kristy S Hwang +4 more
doaj +3 more sources
Illicit stimulant use is associated with abnormal substantia nigra morphology in humans. [PDF]
PLoS ONE, 2013 Use of illicit stimulants such as methamphetamine, cocaine, and ecstasy is an increasing health problem. Chronic use can cause neurotoxicity in animals and humans but the long-term consequences are not well understood. The aim of the current study was to
Gabrielle Todd +7 more
doaj +1 more source
Measurement of the adult human midbrain with transcranial ultrasound.
PLoS ONE, 2021 BackgroundTranscranial sonography is increasingly used to aid clinical diagnoses of movement disorders, for example, to identify an enlarged area of substantia nigra echogenicity in patients with Parkinson's disease.ObjectiveThe current study ...
Karl Aoun +5 more
doaj +1 more source
MRI T2 and T2* relaxometry to visualize neuromelanin in the dorsal substantia nigra pars compacta
NeuroImage, 2020 Visualizing gradual changes in neuromelanin distribution within the substantia nigra is an important metric used to monitor the progression of Parkinsonism.
Hansol Lee +5 more
doaj +1 more source
Neuromelanin Imaging and Dopaminergic Loss in Parkinson’s Disease
Frontiers in Aging Neuroscience, 2016 Parkinson’s disease (PD) is a progressive neurodegenerative disorder in which the major pathologic substrate is a loss of dopaminergic neurons from the substantia nigra.
Ioannis Ugo Isaias +9 more
doaj +1 more source