Results 1 to 10 of about 123,595 (337)

A Direct Cortico-Nigral Pathway as Revealed by Constrained Spherical Deconvolution Tractography in Humans

Frontiers in Human Neuroscience, 2016
Substantia nigra is an important neuronal structure, located in the ventral midbrain, that exerts a regulatory function within the basal ganglia circuitry through the nigro-striatal pathway.
Alberto Cacciola, Demetrio Milardi, Demetrio Milardi, Giuseppe Pio Anastasi, Gianpaolo Antonio Basile, Pietro Ciolli, Mariangela Irrera, Giuseppina Cutroneo, Daniele Bruschetta, Giuseppina Rizzo, Stefania Mondello, Placido Bramanti, Angelo Quartarone, Angelo Quartarone   +13 more
doaj   +1 more source

A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy

BMC Neurology, 2020
Background Parkinsonian variant of multiple system atrophy is a neurodegenerative disorder frequently misdiagnosed as Parkinson’s disease. No early imaging biomarkers currently differentiate these disorders.
Rita Moiron Simões, Ana Castro Caldas, Joana Grilo, Daisy Correia, Carla Guerreiro, Patrícia Pita Lobo, Anabela Valadas, Marguerita Fabbri, Leonor Correia Guedes, Miguel Coelho, Mario Miguel Rosa, Joaquim J. Ferreira, Sofia Reimão   +12 more
doaj   +1 more source

AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models

Genes, 2017
Gene delivery using adeno-associated virus (AAV) vectors is a widely used method to transduce neurons in the brain, especially due to its safety, efficacy, and long-lasting expression.
Katrina Albert, M. Voutilainen, A. Domanskyi, M. Airavaara   +3 more
semanticscholar   +1 more source

Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping

American Journal of Neuroradiology, 2016
The authors evaluated 24 patients with Parkinson disease and 24 age- and sex-matched healthy controls who underwent 3T MR imaging with a 3D multiecho gradient-echo sequence.
M. Azuma, Toshinori Hirai, Kazumichi Yamada, Satoshi Yamashita, Yukio Ando, Machiko Tateishi, Y. Iryo, Tetsuya Yoneda, M. Kitajima, Yi Wang, Y. Yamashita   +10 more
semanticscholar   +1 more source

Ultra-High Field MRI Post Mortem Structural Connectivity of the Human Subthalamic Nucleus, Substantia Nigra, and Globus Pallidus

Frontiers in Neuroanatomy, 2016
Introduction: The subthalamic nucleus, substantia nigra, and globus pallidus, three nuclei of the human basal ganglia, play an important role in motor, associative, and limbic processing.
B. Plantinga, A. Roebroeck, V. Kemper, K. Uludağ, Maartje Melse, J. Mai, M. Kuijf, A. Herrler, A. Jahanshahi, B. M. ter Haar Romeny, Y. Temel   +10 more
semanticscholar   +1 more source

MRI T2 and T2* relaxometry to visualize neuromelanin in the dorsal substantia nigra pars compacta

NeuroImage, 2020
Visualizing gradual changes in neuromelanin distribution within the substantia nigra is an important metric used to monitor the progression of Parkinsonism.
Hansol Lee, Sun-Yong Baek, Eun-Joo Kim, Gi Yeong Huh, Jae-Hyeok Lee, HyungJoon Cho   +5 more
doaj  

640-Slice CT Measurement of Superior Orbital Fissure as Gateway for Light into the Brain: Statistical Evaluation of Area and Distance. [PDF]

PLoS ONE, 2016
OBJECTIVE:Our aim was to provide normative data concerning superior orbital fissure area (SOFA), ocular skin and the substantia nigra (D-SS) and orbital fissure and the substantia nigra (D-SOF-S) distances by CT scan in adult Caucasian population ...
Alice La Marra, Simone Quarchioni, Fabiana Ferrari, Giovanni Luca Gravina, Antonio Barile, Lorenzo Maria Gregori, Ernesto Di Cesare, Alessandra Splendiani   +7 more
doaj   +1 more source

Extended Anatomical Grading in Diffuse Axonal Injury Using MRI: Hemorrhagic Lesions in the Substantia Nigra and Mesencephalic Tegmentum Indicate Poor Long-Term Outcome

Journal of Neurotrauma, 2017
Clinical outcome after traumatic diffuse axonal injury (DAI) is difficult to predict. In this study, three magnetic resonance imaging (MRI) sequences were used to quantify the anatomical distribution of lesions, to grade DAI according to the Adams ...
Sami Abu Hamdeh, N. Marklund, Marianne Lannsjö, T. Howells, R. Raininko, J. Wikström, P. Enblad   +6 more
semanticscholar   +1 more source

Thalamic ventrobasal stimulation for pain relief: probable mechanisms, pathways and neurotransmitters

Arquivos de Neuro-Psiquiatria, 1994
Thalamic ventrobasal (VB) stimulation, first performed by Mazars, in 1961, is a valuable means for treating central and deafferentation pain. The way it acts to achieve pain relief, however, is still a matter of controversy.
Osvaldo Vilela Filho
doaj   +1 more source

Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis

Cell Death and Disease, 2021
Iron deposition is present in main lesion areas in the brains of patients with Parkinson’s disease (PD) and an abnormal iron content may be associated with dopaminergic neuronal cytotoxicity and degeneration in the substantia nigra of the midbrain ...
Jian-Jun Guo, Feng Yue, Dong-Yan Song, Luc Bousset, Xin Liang, Jing Tang, Lin Yuan, Wen Li, Ronald Melki, Yong Tang, Piu Chan, Chuang Guo, Jia-Yi Li   +12 more
doaj   +1 more source