Results 1 to 10 of about 71,882 (196)

Substantia nigra and blood gene signatures and biomarkers for Parkinson’s disease from integrated multicenter microarray-based transcriptomic analyses [PDF]

open access: yesFrontiers in Aging Neuroscience
BackgroundParkinson’s disease (PD) is a complex, common neurodegenerative disorder with unclear etiology. The pathogenic hallmark is the death of dopaminergic neurons in the substantia nigra. PD diagnosis depends on clinical manifestation of symptoms but
Hui-Hui Fan   +11 more
doaj   +2 more sources

Don't die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra? [PDF]

open access: yesPLoS ONE
A hallmark of Parkinson's disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are affected to the same extent.
Simone Steinbach   +8 more
doaj   +2 more sources

Application value of multiparametric MRI for evaluating iron deposition in the substantia nigra in Parkinson's disease

open access: yesFrontiers in Neurology, 2023
ObjectiveThis study aimed to investigate the application value of multi-parametric magnetic resonance imaging (MRI) in the diagnosis of iron deposition in the substantia nigra dense zone in Parkinson's disease (PD) and to evaluate the diagnostic value of
Qing Cao   +7 more
doaj   +1 more source

In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson's disease using neuromelanin-sensitive MRI: Replication in two cohorts.

open access: yesPLoS ONE, 2023
Patients with Parkinson's disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson's disease simultaneously
Kristy S Hwang   +4 more
doaj   +3 more sources

Illicit stimulant use is associated with abnormal substantia nigra morphology in humans. [PDF]

open access: yesPLoS ONE, 2013
Use of illicit stimulants such as methamphetamine, cocaine, and ecstasy is an increasing health problem. Chronic use can cause neurotoxicity in animals and humans but the long-term consequences are not well understood. The aim of the current study was to
Gabrielle Todd   +7 more
doaj   +1 more source

Measurement of the adult human midbrain with transcranial ultrasound.

open access: yesPLoS ONE, 2021
BackgroundTranscranial sonography is increasingly used to aid clinical diagnoses of movement disorders, for example, to identify an enlarged area of substantia nigra echogenicity in patients with Parkinson's disease.ObjectiveThe current study ...
Karl Aoun   +5 more
doaj   +1 more source

THE SUBSTANTIA NIGRA SOEMERINGI [PDF]

open access: yesThe Journal OF Nervous and Mental Disease, 1909
n ...
Bauer, Julius, Karpas, M. J.
openaire   +2 more sources

Crystals in the Substantia Nigra [PDF]

open access: yesACS Chemical Neuroscience, 2019
Crystals of TiO2 and CaO were detected in electron-beam exposed extracts of four substantia nigra specimens of Parkinson's disease donors. A likely precursor of the CaO crystals is inflammatory calcium oxalate dihydrate, decomposing according to CaC2O4·2H2O → CaO + CO↑ + CO2↑ + 2H2O↑.
Adam Heller, Sheryl S. Coffman
openaire   +3 more sources

Neuromelanin Imaging and Dopaminergic Loss in Parkinson’s Disease

open access: yesFrontiers in Aging Neuroscience, 2016
Parkinson’s disease (PD) is a progressive neurodegenerative disorder in which the major pathologic substrate is a loss of dopaminergic neurons from the substantia nigra.
Ioannis Ugo Isaias   +9 more
doaj   +1 more source

Combined Application of Quantitative Susceptibility Mapping and Diffusion Kurtosis Imaging Techniques to Investigate the Effect of Iron Deposition on Microstructural Changes in the Brain in Parkinson’s Disease

open access: yesFrontiers in Aging Neuroscience, 2022
ObjectivesBrain iron deposition and microstructural changes in brain tissue are associated with Parkinson’s disease (PD). However, the correlation between these factors in Parkinson’s disease has been little studied.
Lin Yang   +12 more
doaj   +1 more source

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