Results 1 to 10 of about 120,800 (295)
Increased free water in the substantia nigra in idiopathic REM sleep behaviour disorder.
Brain : a journal of neurology, 2021 Imaging markers sensitive to neurodegeneration in the substantia nigra are critically needed for future disease-modifying trials. Previous studies have demonstrated the utility of posterior substantia nigra free water as a marker of progression in ...
Liche Zhou +13 more
semanticscholar +1 more source
Nature Communications, 2020 We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN), generated by sequencing approximately 17,000 nuclei from matched cortical and SN samples.
D. Agarwal +8 more
semanticscholar +1 more source
THE SUBSTANTIA NIGRA SOEMERINGI [PDF]
The Journal OF Nervous and Mental Disease, 1909 n ...
Bauer, Julius, Karpas, M. J.
openaire +2 more sources
Crystals in the Substantia Nigra [PDF]
ACS Chemical Neuroscience, 2019 Crystals of TiO2 and CaO were detected in electron-beam exposed extracts of four substantia nigra specimens of Parkinson's disease donors. A likely precursor of the CaO crystals is inflammatory calcium oxalate dihydrate, decomposing according to CaC2O4·2H2O → CaO + CO↑ + CO2↑ + 2H2O↑.
Adam Heller, Sheryl S. Coffman
openaire +3 more sources
Spatiotemporal changes in substantia nigra neuromelanin content in Parkinson's disease.
Brain : a journal of neurology, 2020 This study aimed to investigate the spatiotemporal changes in neuromelanin-sensitive MRI signal in the substantia nigra and their relation to clinical scores of disease severity in patients with early or progressing Parkinson's disease and patients with ...
E. Biondetti +12 more
semanticscholar +1 more source
Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease
Aging Cell, 2019 Parkinson's disease prevalence is rapidly increasing in an aging global population. With this increase comes exponentially rising social and economic costs, emphasizing the immediate need for effective disease‐modifying treatments.
B. G. Trist, D. Hare, K. Double
semanticscholar +1 more source
Mitochondrial dysfunction within the synapses of substantia nigra neurons in Parkinson’s disease
npj Parkinson's Disease, 2018 Mitochondrial dysfunction within the cell bodies of substantia nigra neurons is prominent in both ageing and Parkinson’s disease. The loss of dopaminergic substantia nigra neurons in Parkinson’s disease is associated with loss of synapses within the ...
A. Reeve +6 more
semanticscholar +1 more source
American Journal of Neuroradiology, 2018 BACKGROUND AND PURPOSE: Several new MR imaging techniques have shown promising results in patients with Parkinson disease; however, the comparative diagnostic values of these measures at the individual level remain unclear.
N. Pyatigorskaya +9 more
semanticscholar +1 more source
PLoS ONE, 2018 Presynaptic cannabinoid-1 receptors (CB1-R) bind endogenous and exogenous cannabinoids to modulate neurotransmitter release. CB1-Rs are expressed throughout the basal ganglia, including striatum and substantia nigra, where they play a role in learning ...
Margaret I Davis +7 more
semanticscholar +1 more source