Results 11 to 20 of about 71,981 (295)

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

Nature Communications, 2020
The substantia nigra is important in neurological disease, particularly movement disorders. Here the authors provide a single cell transcriptomic atlas for the human substantia nigra.
Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M. Caffrey, Jimena Monzón-Sandoval, Rory Bowden, Javier Alegre-Abarrategui, Richard Wade-Martins, Caleb Webber   +8 more
doaj   +1 more source

A robust method for the detection of small changes in relaxation parameters and free water content in the vicinity of the substantia nigra in Parkinson's disease patients.

PLoS ONE, 2021
Alterations in the substantia nigra are strongly associated with Parkinson's disease. However, due to low contrast and partial volume effects present in typical MRI images, the substantia nigra is not of sufficient size to obtain a reliable segmentation ...
Krzysztof Dzieciol, Elene Iordanishvili, Zaheer Abbas, Adjmal Nahimi, Michael Winterdahl, N Jon Shah   +5 more
doaj   +1 more source

9.4 T MR microscopy of the substantia nigra with pathological validation in controls and disease

NeuroImage: Clinical, 2017
Background: The anatomy of the substantia nigra on conventional MRI is controversial. Even using histological techniques it is difficult to delineate with certainty from surrounding structures.
LA Massey, MA Miranda, O Al-Helli, HG Parkes, JS Thornton, P-W So, MJ White, L Mancini, C Strand, J Holton, AJ Lees, T Revesz, TA Yousry   +12 more
doaj   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Microstructural changes within the basal ganglia differ between Parkinson disease subtypes

Frontiers in Neuroanatomy, 2016
Diffusion tensor imaging (DTI) of the substantia nigra has shown promise in detecting and quantifying neurodegeneration in Parkinson disease (PD). It remains unknown, however, whether differences in microstructural changes within the basal ganglia ...
Lidia M Nagae, Justin M Honce, Jody eTanabe, Erika eShelton, Stefan H Sillau, Brian D Berman, Brian D Berman   +6 more
doaj   +1 more source

The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis. [PDF]

PLoS ONE, 2010
BACKGROUND: The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences of injections of 3,4-dihydroxyphenylacetaldehyde (DOPAL), a toxic metabolite of dopamine, into the substantia nigra of rats on motor behavior ...
W Michael Panneton, V B Kumar, Qi Gan, William J Burke, James E Galvin   +4 more
doaj   +1 more source

Signal alterations of the basal ganglia in the differential diagnosis of Parkinson’s disease: a retrospective case-controlled MRI data bank analysis

BMC Neurology, 2012
Background Based upon the acquainted loss of dopaminergic neurons in the substantia nigra in Parkinson’s disease (PD), we hypothesised changes in magnetic resonance imaging signal intensities of the basal ganglia to be useful as an additional technical ...
Jesse Sarah, Kassubek Jan, Müller Hans-Peter, Ludolph Albert C, Unrath Alexander   +4 more
doaj   +1 more source

Chemical Exchange Saturation Transfer MRI Signal Loss of the Substantia Nigra as an Imaging Biomarker to Evaluate the Diagnosis and Severity of Parkinson's Disease

Frontiers in Neuroscience, 2017
The early diagnosis of Parkinson's disease (PD) and the accurate evaluation of disease severity are crucial for intervention and treatment in PD patients.
Chunmei Li, Min Chen, Xuna Zhao, Rui Wang, Haibo Chen, Wen Su, Shuhua Li, Baohui Lou, Guodong Song, Shuai Zhang, Jintao Zhang, Jinyuan Zhou   +11 more
doaj   +1 more source

Eyes as Gateways for Environmental Light to the Substantia Nigra: Relevance in Parkinson’s Disease

The Scientific World Journal, 2014
Recent data indicates that prolonged bright light exposure of rats induces production of neuromelanin and reduction of tyrosine hydroxylase positive neurons in the substantia nigra. This effect was the result of direct light reaching the substantia nigra
Stefania Romeo, Daniela Di Camillo, Alessandra Splendiani, Marta Capannolo, Cristina Rocchi, Gabriella Aloisi, Irene Fasciani, Giovanni U. Corsini, Eugenio Scarnati, Luca Lozzi, Roberto Maggio   +10 more
doaj   +1 more source

The MSA Atrophy Index (MSA‐AI): An Imaging Marker for Diagnosis and Clinical Progression in Multiple System Atrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Reliable biomarkers are essential for tracking disease progression and advancing treatments for multiple system atrophy (MSA). In this study, we propose the MSA Atrophy Index (MSA‐AI), a novel composite volumetric measure to distinguish MSA from related disorders and monitor disease progression. Methods Seventeen participants with an
Paula Trujillo, Kilian Hett, Amy Cooper, Amy E. Brown, Jessica Iregui, Manus J. Donahue, M. Erik Landman, Italo Biaggioni, Margaret Bradbury, Cynthia Wong, David Stamler, Daniel O. Claassen   +11 more
wiley   +1 more source