Results 11 to 20 of about 76,030 (307)
PLoS ONE, 2021 Alterations in the substantia nigra are strongly associated with Parkinson's disease. However, due to low contrast and partial volume effects present in typical MRI images, the substantia nigra is not of sufficient size to obtain a reliable segmentation ...
Krzysztof Dzieciol +5 more
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Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation
Neurobiology of Disease, 2015 Although gliosis is a normal response to brain injury, reports on the extent of astrogliosis in the degenerating substantia nigra in Parkinson’s disease (PD) are conflicting.
Junchao Tong +8 more
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Neurobiology of Disease, 1997 Dopaminergic neurons of the substantia nigra pars compacta were examined in the rat brain following striatal infarction subsequent to transient focal cerebral ischemia.
Marc A. Soriano +4 more
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Microstructural changes within the basal ganglia differ between Parkinson disease subtypes
Frontiers in Neuroanatomy, 2016 Diffusion tensor imaging (DTI) of the substantia nigra has shown promise in detecting and quantifying neurodegeneration in Parkinson disease (PD). It remains unknown, however, whether differences in microstructural changes within the basal ganglia ...
Lidia M Nagae +6 more
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The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis. [PDF]
PLoS ONE, 2010 BACKGROUND: The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences of injections of 3,4-dihydroxyphenylacetaldehyde (DOPAL), a toxic metabolite of dopamine, into the substantia nigra of rats on motor behavior ...
W Michael Panneton +4 more
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DIFFERENTIALLY EXPRESSED GENES AND THEIR SIGNIFICANCE THE SUBSTANTIA NIGRA OF MICE WITH 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED PARKINSON’S DISEASE [PDF]
精准医学杂志, 2023 Objective To investigate the differentially expressed genes (DEGs) in the substantia nigra of mice with Parkinson’s disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) based on bioinformatics, as well as their role in the ...
LI Beining, YAO Zhengyang, JIAO Qian, CHEN Xi, JIANG Hong, DU Xixun
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Frontiers in Aging NeuroscienceBackgroundParkinson’s disease (PD) is a complex, common neurodegenerative disorder with unclear etiology. The pathogenic hallmark is the death of dopaminergic neurons in the substantia nigra. PD diagnosis depends on clinical manifestation of symptoms but
Hui-Hui Fan +11 more
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Frontiers in Neuroscience, 2017 The early diagnosis of Parkinson's disease (PD) and the accurate evaluation of disease severity are crucial for intervention and treatment in PD patients.
Chunmei Li +11 more
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Crystals in the Substantia Nigra [PDF]
ACS Chemical Neuroscience, 2019 Crystals of TiO2 and CaO were detected in electron-beam exposed extracts of four substantia nigra specimens of Parkinson's disease donors. A likely precursor of the CaO crystals is inflammatory calcium oxalate dihydrate, decomposing according to CaC2O4·2H2O → CaO + CO↑ + CO2↑ + 2H2O↑.
Adam Heller, Sheryl S. Coffman
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Eyes as Gateways for Environmental Light to the Substantia Nigra: Relevance in Parkinson’s Disease
The Scientific World Journal, 2014 Recent data indicates that prolonged bright light exposure of rats induces production of neuromelanin and reduction of tyrosine hydroxylase positive neurons in the substantia nigra. This effect was the result of direct light reaching the substantia nigra
Stefania Romeo +10 more
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