Results 11 to 20 of about 123,595 (337)
Nature Communications, 2020 The substantia nigra is important in neurological disease, particularly movement disorders. Here the authors provide a single cell transcriptomic atlas for the human substantia nigra.
Devika Agarwal +8 more
doaj +2 more sources
Substantia nigra and blood gene signatures and biomarkers for Parkinson’s disease from integrated multicenter microarray-based transcriptomic analyses [PDF]
Frontiers in Aging NeuroscienceBackgroundParkinson’s disease (PD) is a complex, common neurodegenerative disorder with unclear etiology. The pathogenic hallmark is the death of dopaminergic neurons in the substantia nigra. PD diagnosis depends on clinical manifestation of symptoms but
Hui-Hui Fan +11 more
doaj +2 more sources
Illicit stimulant use is associated with abnormal substantia nigra morphology in humans. [PDF]
PLoS ONE, 2013 Use of illicit stimulants such as methamphetamine, cocaine, and ecstasy is an increasing health problem. Chronic use can cause neurotoxicity in animals and humans but the long-term consequences are not well understood. The aim of the current study was to
Gabrielle Todd +7 more
doaj +2 more sources
Don't die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra? [PDF]
PLoS ONEA hallmark of Parkinson's disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are affected to the same extent.
Simone Steinbach +8 more
doaj +2 more sources
The subcortical cocktail problem; mixed signals from the subthalamic nucleus and substantia nigra.
PLoS ONE, 2015 The subthalamic nucleus and the directly adjacent substantia nigra are small and important structures in the basal ganglia. Functional magnetic resonance imaging studies have shown that the subthalamic nucleus and substantia nigra are selectively ...
Gilles de Hollander +2 more
doaj +2 more sources
Frontiers in Aging Neuroscience, 2015 Parkinson’s disease has been associated with the selective loss of neurons in the substantia nigra pars compacta. Increasing evidence suggests that oxidative stress plays a major role. The resulting increase in reactive oxygen species triggers a sequence
Selva eRivas - Arancibia +5 more
doaj +2 more sources
Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease [PDF]
npj Parkinson's DiseaseParkinson’s disease (PD) is characterized by a progressive loss of dopaminergic neurons. Exercise has been reported to slow the clinical progression of PD.
Bart de Laat +16 more
doaj +2 more sources
Frontiers in Neurology, 2023 ObjectiveThis study aimed to investigate the application value of multi-parametric magnetic resonance imaging (MRI) in the diagnosis of iron deposition in the substantia nigra dense zone in Parkinson's disease (PD) and to evaluate the diagnostic value of
Qing Cao +7 more
doaj +1 more source
Increased free water in the substantia nigra in idiopathic REM sleep behaviour disorder.
Brain : a journal of neurology, 2021 Imaging markers sensitive to neurodegeneration in the substantia nigra are critically needed for future disease-modifying trials. Previous studies have demonstrated the utility of posterior substantia nigra free water as a marker of progression in ...
Liche Zhou +13 more
semanticscholar +1 more source