Results 261 to 270 of about 134,010 (347)

Molecularly Engineered Phenoxazinone‐Skeleton Cascade‐Activated NIR Probes for Monitoring Fe2+/Viscosity in Ferroptosis‐Mediated Parkinson's Disease

Advanced Science, Volume 13, Issue 26, 8 May 2026.
A series of Fe2+/viscosity cascade‐activated NIR fluorescence probes (NP1–5) are synthesized, and NP3 is selected for its optimal properties. To verify application of NP3 in ferroptosis intervention in PD, PQR NPs, is constructed by NP3 and quercetin self‐assembling.
Lixia Guo, Tao Liu, Hongfei Wang, Qi Gao, Zhaobo Yang, Zumeng Wang, Chenlong Li, Yubing Kang, Kahleong Lim, Wen Liu, Li Lu, Chengwu Zhang   +11 more
wiley   +1 more source

Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism. [PDF]

Cell Mol Neurobiol
Ayala DA, Hall GM, Das D, Tijerina E, Villagran LL, Khan Z, Paliwal D, Anand A, Rimer M, Srinivasan R.   +9 more
europepmc   +1 more source

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

Cerebral iron deposition in the Globus pallidus and Substantia nigra of aging dogs and cats presenting as bilateral hypointensity on T2w and iron-sensitive MRI sequences (SWI, T2*). [PDF]

Front Vet Sci
Fischer C, Schaub S, Körber SSE, Hoppe MI, Büttner K, Schmidt MJ.   +5 more
europepmc   +1 more source

Advancing biomarker development for chronic traumatic encephalopathy: Summary and recommendations from the 2025 Leon Thal Summit

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The 2025 Leon Thal Summit convened an international panel of clinicians, neuroscientists, neuropathologists, and neuroimaging specialists to evaluate the current state of biomarker development for chronic traumatic encephalopathy (CTE) and to outline priorities for advancing translational research for this important area.
Charles Bernick, Brooke Conway Kleven, Michael L. Alosco, Hector Arciniega, Nicholas Ashton, Andrew Bender, Kevin F. Bieniek, Dietmar Cordes, Laura Cordes, Douglas I. Katz, Dirk Keene, Jefferson Kinney, LeeAnn Mandarino, Dawn Matthews, Anne McKee, Jesse Mez, Edwin C. Oh, Elaine Peskind, Gil D. Rabinovici, Eric M. Reiman, Robert A. Stern, Neil Vasdev, Henrik Zetterberg, Xiaowei Zhuang, Jeffrey L. Cummings   +24 more
wiley   +1 more source

Effect of age on substantia nigra subregions using neuromelanin-sensitive magnetic resonance imaging overlapping on quantitative susceptibility mapping. [PDF]

Quant Imaging Med Surg
Kuang C, Liu WV, Li L, Liu C, Zha Y.
europepmc   +1 more source

Seven tesla MRI of the substantia nigra in patients with rapid eye movement sleep behavior disorder

, 2017
Daniela Frosini, Mirco Cosottini, Graziella Donatelli, Mauro Costagli, Laura Biagi, Claudio Pacchetti, Michele Terzaghi, Pietro Cortelli, Dario Arnaldi, Enrica Bonanni, Michela Tosetti, Ubaldo Bonuccelli, Roberto Ceravolo   +12 more
openalex   +2 more sources

circPDE4B downregulation triggers GEMIN5‑dependent translational stress response and autophagy to reduce MAPT pathology

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Circular RNAs (circRNAs) are emerging as key regulators of gene expression, synaptic plasticity, and neuronal function in Alzheimer's disease (AD). Here, we characterize the biological actions of circPDE4B, a highly expressed circRNA markedly reduced in AD. METHODS circPDE4B knockdown in neuronal progenitor cells was combined with
Sambhavi Puri, Sophie J. F. van der Spek, Mintao Lin, Zihan Wang, Jacob Porter, Junming Hu, Liyuan Hu, Alejandro N. Rondón‐Ortiz, Alexander Knyshov, Jenna L. Libera, Scott E. Counts, Debomoy K. Lahiri, Julia TCW, Andrew Emili, Xiaoling Zhang, Benjamin Wolozin   +15 more
wiley   +1 more source

Increased iron deposition in putamen and substantia nigra correlates with cognitive function in cerebral small vessel disease: A quantitative susceptibility mapping study. [PDF]

J Cereb Blood Flow Metab
Feng M, Wang Y, Liu X, Zhang S, Lu W, Wang T, Song H, Lu J.   +7 more
europepmc   +1 more source