Results 251 to 260 of about 86,799 (302)

Dopamine release in substantia nigra?

Nature, 1976
IN addition to the axons which project to the nucleus caudatus1,2, the dopamine (DA)-containing perikarya of the substantia nigra have extensive dendritic processes. These dendrites, observed after Golgi staining3–5 and by electron microscopy3,4, contain relatively large amounts of DA—revealed by histofluorescence6—and vesicle–like structures4.
KORF, J, ZIELEMAN, M, WESTERINK, BHC
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The neuromelanin of the human substantia nigra

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1991
The pigment of the human substantia nigra was isolated after extraction of lipids and proteins with 2% sodium cholate in 30% ethanol followed by 2% sodium dodecyl sulfate in 10% glycerol. The pigment was hydrolysed with HI or degraded by treatment with KMNO4 and the samples were examined for compounds known to derive from pheomelanin (4-amino-3 ...
R, Carstam, C, Brinck, A, Hindemith-Augustsson, H, Rorsman, E, Rosengren   +4 more
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Diagnostic evaluation of the substantia nigra

Neuropathology and Applied Neurobiology, 1996
An improved method for the histopathological evaluation of the substantia nigra for diagnostic purposes is proposed. This method takes advantage of the natural architecture of the constituent cell clusters of the substantia nigra by combining standardized sections in the horizontal plane and simple quantification. The use of this standardized technique
D A, McRitchie, G M, Halliday, R, Pamphlett   +2 more
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Cytoarchitecture of the substantia nigra in the rat

American Journal of Anatomy, 1970
AbstractMidbrains of ten young adult rats were sectioned serially in three planes to study the detailed cytoarchitecture of the substantia nigra. These neurons measure 8 to 17 μ in diameter. In comparison, the largest neurons in the midbrain measure 20 to 40 μ; hence, neurons are designated according to size as follows: those measuring 18 to 40 μ ...
J, Hanaway, J A, McConnell, M G, Netsky
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Substantia Nigra Hyperactivity in Schizophrenia

Biological Psychiatry, 2013
Mapping the clinical features of schizophrenia to circuits in the brain is a major goal for schizophrenia researchers. The prefrontal cortex (PFC), the ventral midbrain, and the striatum are among the brain areas of primary interest. The PFC has been linked to cognitive deficits, especially impairment of working memory.
Stephan, Heckers, Christine, Konradi
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The role of GABA in the substantia nigra

Nature, 1978
STRIATONIGRAL GABAergic fibres are widely believed to exert a tonic inhibitory influence on the dopamine (DA)-containing cells of the substantia nigra (SN), and contraversive and ipsiversive circling behaviour can be explained in terms of a greater or lesser activity of the dopaminergic neurones, respectively1,2. However, the blockade of γ-aminobutyric
T A, James, M S, Starr
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Synapses in the rat substantia nigra

Tissue and Cell, 1971
The composition and organization of the input to the rat substantia nigra were studied with the electron microscope. Four distinct types of synaptic boutons were described. The first contained small (381 A), clear synaptic vesicles. The second type contained the small, clear vesicles and several large, dense-core vesicles.
R L, Gulley, M, Smithberg
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Evidence for autapses in the substantia nigra

Brain Research, 1980
Intracellular recording and intracellular HRP staining were employed to trace the recurrent terminal plexus of cat substantia nigra pars reticulata neurons. Autaptic neurons were labeled. The axon of an autaptic neuron was found to emit a recurrent collateral which distributed 'en passage' and terminal boutons contacting dendrites of the parent cell ...
A B, Karabelas, D P, Purpura
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The substantia nigra and stereotyped behaviour

European Journal of Pharmacology, 1972
Abstract The acute and chronic effects of bilateral lesions of the substantia nigra upon amphetamine- and apomorphine-induced stereotyped behaviour and its modification by haloperidol and arecoline were studied in the rat. A mild spontaneous stereotyped behaviour was observed during the acute stage following the induction of nigral lesions. In order
B, Costall, R J, Naylor, J E, Olley
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Culture of Substantia Nigra Neurons

Current Protocols in Neuroscience, 1997
AbstractPrimary cultures of nigral tissue are widely used as a model system to assay effects of trophic and toxic agents on dopaminergic neurons. Cultured dopaminergic neurons have been successfully transplanted in animals and led to behavioral improvement in animal models of Parkinson's disease.
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