Results 251 to 260 of about 134,010 (347)

Copper Overload Affects α‐Synuclein Clearance Mechanisms in a Parkinson's Disease In Vitro Model

Advanced Biology, Volume 10, Issue 5, May 2026.
This study reveals that copper overload disrupts neuronal protein clearance, leading to the accumulation of α‐synuclein and its phosphorylated form (p‐S129). By blocking autophagy and impairing the ubiquitin–proteasome system, copper promotes toxic aggregation in dopaminergic cells.
Debora Musarò, Marina Damato, Chiara Coppola, Marco Greco, Michele Maffia   +4 more
wiley   +1 more source

Corticonigral projections recruit substantia nigra pars lateralis dopaminergic neurons for auditory threat memories. [PDF]

Nat Commun
Sansalone L, Twedell EL, Evans RC, Boronat-Garcia A, Zhang R, Khaliq ZM.   +5 more
europepmc   +1 more source

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, Volume 13, Issue 27, 13 May 2026.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

Correction: Distinct spatial transcriptomic patterns of substantia Nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy. [PDF]

Acta Neuropathol Commun
Shin JH, Ruhno KE, Shin C, Kim HJ, Nam SJ, Chung SJ, Moon JH, Kim HJ.   +7 more
europepmc   +1 more source

Vesicular monoamine transporter 2 (VMAT2) overexpression in inferior colliculus (IC)-innervated substantia nigra compacta (SNc) dopaminergic neurons ameliorates noise exposure-induced 6-hydroxydopamine (6-OHDA) vulnerability.

Chi Cui (10201007), Yibo Yao (16274454), Yulong Shi (459712), Jie Lei (579923), Kun Ren (6173954), Kexing Wan (6258182), Tongxia Li (13354935), Gangan Luo (16999848), Qian Xu (119888), Ming Li (91180), Xiang Peng (3092073), Xueke Yang (14648669), Jian Yang (12136), Junsong Du (22559804), Sitong Chen (170590), Bo Tian (625365), Pei Zhang (232846)   +16 more
openalex   +1 more source

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Distinct spatial transcriptomic patterns of substantia Nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy. [PDF]

Acta Neuropathol Commun
Shin JH, Ruhno KE, Shin C, Kim HJ, Nam SJ, Chung SJ, Moon JH, Kim HJ.   +7 more
europepmc   +1 more source

Short-term modulation of inferior colliculus (IC)-substantia nigra compacta (SNc) circuit affects motor deficits induced by acute noise exposure in 6-hydroxydopamine mice.

Chi Cui (10201007), Yibo Yao (16274454), Yulong Shi (459712), Jie Lei (579923), Kun Ren (6173954), Kexing Wan (6258182), Tongxia Li (13354935), Gangan Luo (16999848), Qian Xu (119888), Ming Li (91180), Xiang Peng (3092073), Xueke Yang (14648669), Jian Yang (12136), Junsong Du (22559804), Sitong Chen (170590), Bo Tian (625365), Pei Zhang (232846)   +16 more
openalex   +1 more source

Microphysiological engineering of the capillary interface of substantia nigra dopaminergic neurons to study vascular alterations in Parkinson’s Disease [PDF]

Anika Alim, Yang Hyun Baek, M. J. Lee, Jungwook Paek   +3 more
openalex   +1 more source