Results 231 to 240 of about 86,799 (302)

Transcranial Sonographic Characteristics of Substantia Nigra in End-Stage Renal Disease Patients with Restless Legs Syndrome: A Diagnostic Marker Study. [PDF]

Diagnostics (Basel)
Wang C, Zhan Z, Ding C, Zhang Y, Luo W.
europepmc   +1 more source

Neuropsychological Tests for Detecting Prodromal DLB: A Systematic Review

European Journal of Neurology, Volume 33, Issue 7, July 2026.
ABSTRACT Background The prodromal phase of Dementia with Lewy bodies (DLB) remains unexplored and poorly defined. This systematic review scrutinised studies on the earliest cognitive DLB deficits, focusing on the most useful neuropsychological tests. Methods From an initial pool of 2307 articles, 37 articles met inclusion criteria including either a ...
Francesco Mori, Fabrizia D'Antonio, Giulia Zazzaro, Desirée Conti, Micaela Mitolo, Annachiara Cagnin, Annalena Venneri   +6 more
wiley   +1 more source

Corticonigral projections recruit substantia nigra pars lateralis dopaminergic neurons for auditory threat memories. [PDF]

Nat Commun
Sansalone L, Twedell EL, Evans RC, Boronat-Garcia A, Zhang R, Khaliq ZM.   +5 more
europepmc   +1 more source

Parkinson's Disease Cell Transplantation Therapy: A New Dawn With Pluripotent Stem Cell–Based Therapy

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the midbrain. Cell transplantation, which aims to replace these lost neurons, has emerged as a promising approach. Early attempts using fetal ventral mesencephalic tissue showed proof‐of‐concept, with some patients achieving long‐term motor improvement. However,
Etsuro Nakanishi, Hodaka Yamakado, Nobukatsu Sawamoto, Jun Takahashi, Ryosuke Takahashi   +4 more
wiley   +1 more source

Correction: Distinct spatial transcriptomic patterns of substantia Nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy. [PDF]

Acta Neuropathol Commun
Shin JH, Ruhno KE, Shin C, Kim HJ, Nam SJ, Chung SJ, Moon JH, Kim HJ.   +7 more
europepmc   +1 more source

LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells‐Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
In this study, human astrocytes were obtained from induced pluripotent stem cells (iPSCs) of Parkinson's disease (PD) patients carrying the G2019S LRRK2 mutation, the most common genetic cause of PD. These astrocytes display a reactive and inflammatory profile, with increased GFAP levels, elevated cytokine release, and reduced support for dopaminergic ...
Veronica Mutti, Federica Bono, Zaira Tomasoni, Dounia Fadel, Chiara Gnutti, Giulia Sbrini, Carolina Gaudenzi, Valentina Salvi, Daniela Bosisio, Isabella Russo, Silvia Bolognin, Jens C. Schwamborn, Cristina Missale, Chiara Fiorentini   +13 more
wiley   +1 more source

Distinct spatial transcriptomic patterns of substantia Nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy. [PDF]

Acta Neuropathol Commun
Shin JH, Ruhno KE, Shin C, Kim HJ, Nam SJ, Chung SJ, Moon JH, Kim HJ.   +7 more
europepmc   +1 more source

PBMC circRNA Profiles Distinguish Atypical From Idiopathic Parkinsonism and Track Clinical Severity Across Syndromes

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Early differentiation of atypical Parkinsonian syndromes, including progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), from idiopathic Parkinson's disease (iPD) remains clinically difficult. Circular RNAs are stable regulatory RNA molecules enriched in brain tissue and measurable in peripheral blood mononuclear cells (PBMCs).
Stylianos Ravanidis, Anastasia Bougea, Fedon‐Giasin Kattan, Leonidas Stefanis, Epaminondas Doxakis   +4 more
wiley   +1 more source

Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism. [PDF]

Cell Mol Neurobiol
Ayala DA, Hall GM, Das D, Tijerina E, Villagran LL, Khan Z, Paliwal D, Anand A, Rimer M, Srinivasan R.   +9 more
europepmc   +1 more source