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Spatiotemporal changes in substantia nigra neuromelanin content in Parkinson’s disease [PDF]

open access: yesBrain, 2020
International audienceAbstract This study aimed to investigate the spatiotemporal changes in neuromelanin-sensitive MRI signal in the substantia nigra and their relation to clinical scores of disease severity in patients with early or progressing ...
Emma Biondetti   +2 more
exaly   +4 more sources
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Substantia Nigra and Parkinsonism

Archives of Neurology, 1964
The opinion that parkinsonism is caused by damage of the substantia nigra was advanced by Brissaud 1 on the basis of the findings in a case of Charcot's studied by Bechet 2 and Blocq and Marinesco. 3 In a series of 54 autopsies Tretiakoff 4 found the substantia nigra degenerated in 16 categories of neurologic disorder including three cases of ...
openaire   +2 more sources

Innervation of the substantia nigra

Cell and Tissue Research, 2004
This review describes inputs to neurons in the substantia nigra and contrasts them with the action of agonists for the putative receptors through which they act. Special emphasis is placed on gamma-aminobutyric acid (GABA) afferents. Dopamine released from the somato-dendritic compartment of dopamine neurons and endocannabinoids released from dopamine ...
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Neuropathology of the Substantia nigra

European Neurology, 2008
Neuronal subpopulations of the substantia nigra pars compacta can be separated into two functionally distinct nigrostriatal projections, the ventral tier which is poorly melanised, and the dorsal tier which is well melanised. In Parkinson’s disease, juvenile-onset parkinsonism with dystonia and striatonigral degeneration the ventral tier is more ...
openaire   +2 more sources

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