Results 221 to 230 of about 134,010 (347)

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Neuromelanin-targeted ¹⁸F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques. [PDF]

EJNMMI Res
Feng H, Tu N, Wang K, Ma X, Zhang Z, Liu Z, Cheng Z, Bu L.   +7 more
europepmc   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Intraarterial microbubble delivery enhances focused ultrasound induced blood brain barrier opening in the murine substantia nigra. [PDF]

Sci Rep
Li H, Lee YH, Zen X, Huang MW, Liu CW, Ho EP, Ou-Yang CH, Lin HI, Chen CA, Chang YY, Liu HL, Lin CH.   +11 more
europepmc   +1 more source

Efficacy of omega‐3 fatty acids as a functional food: a multifaceted approach to health reinforcement

Journal of the Science of Food and Agriculture, Volume 106, Issue 8, Page 4521-4549, June 2026.
Abstract Omega‐3 fatty acids (omega‐3s) are polyunsaturated fatty acids linked with numerous health benefits. Omega‐3s exhibit multifaceted activities through various mechanisms. Eicosapentaenoic acid (EPA) alleviates oxidative stress by lowering reactive oxygen species and improving oxidative stress in brain tissues and acts against neurodegenerative ...
Md Faruque Ahmad, Abdulrahman A Alsayegh, Anjum Khanam, Awais Ahmed, António Raposo, Farkad Bantun, Md Zeyaullah, Ahmad O Babalghith, Abdullah F Aldairi, Boshra Mozaffar, Mohammed F Bajahzer, Mohamed H Abdelrahman, Mohammad Intakhab Alam   +12 more
wiley   +1 more source

The spatial landscape of glial pathology and T cell response in Parkinson's disease substantia nigra. [PDF]

Nat Commun
Ma M, Paryani F, Jakubiak K, Xia S, Antoku S, Kannan A, Lee J, Madden N, Senthil Kumar S, Li J, Chen D, Hargus G, Mahajan A, Flowers X, Harms AS, Sulzer D, Goldman JE, Sims PA, Al-Dalahmah O.   +18 more
europepmc   +1 more source

High-Intensity Exercise Acutely Increases Substantia Nigra and Prefrontal Brain Activity in Parkinson’s Disease

, 2017
Neil Kelly, Kimberly H. Wood, Jane B. Allendorfer, Matthew P. Ford, C. Scott Bickel, Jon Marstrander, Amy W. Amara, Thomas Anthony, Marcas M. Bamman, Frank M. Skidmore   +9 more
openalex   +2 more sources

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Glial cell-specific proteomic data from the substantia nigra of a rat 6-OHDA and fluorocitrate model of astrocyte death and microglial activation. [PDF]

Data Brief
Kadłuczka J, Chubukova T, Mielczarek P, Maziak A, Roman A, Napieralska E, Kuter KZ.   +6 more
europepmc   +1 more source

Soemmerring and the Substantia Nigra [PDF]

Medical History, 1968
R. L. M Faull, D. W. Taylor, J. B. Carman   +2 more
openaire   +1 more source