Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda +5 more
wiley +1 more source
A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study. [PDF]
Eggers B +10 more
europepmc +1 more source
Amylin analogues as a novel perspective in anti‐obesity therapy
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley +1 more source
Restoring failed inhibition in the substantia nigra pars reticulata suppresses absence seizures in rats. [PDF]
Palmer D, Forcelli PA.
europepmc +1 more source
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang +8 more
wiley +1 more source
Substantia nigra-related gene polymorphisms associated with acute antipsychotic-induced movement disorders. [PDF]
Hashimoto K.
europepmc +1 more source
Dopamine D1 Receptor Immunoreactivity on Fine Processes of GFAP-Positive Astrocytes in the Substantia Nigra Pars Reticulata of Adult Mouse [PDF]
Katsuhiro Nagatomo +6 more
openalex +1 more source
Japanese Encephalitis: Characteristic Imaging in Substantia Nigra, Thalamus, and Basal Ganglia. [PDF]
Sekiguchi K +3 more
europepmc +1 more source
Abstract Motor imagery (MI) can facilitate movement in healthy individuals and patient populations. People with Parkinson's (PwP) experience debilitating motor symptoms, yet appear to have relatively intact MI capabilities, which may position MI as an effective therapeutic adjunct to existing interventions for PwP.
Camilla Woodrow‐Hill +5 more
wiley +1 more source
Substantia nigra pars reticulata involvement in auditory hallucinations of treatment-resistant schizophrenia: a deep brain stimulation case report. [PDF]
Shen A +13 more
europepmc +1 more source

