Results 211 to 220 of about 86,799 (302)

Radiomic Signature of the Substantia Nigra on Neuromelanin‐Sensitive MRI Distinguishes Bipolar II Disorder From Unipolar Depression

Brain and Behavior, Volume 16, Issue 7, July 2026.
This radiomics pipeline employed neuromelanin‐sensitive MRI to extract 2,854 features from bilateral nigral ROIs in BD‐II, UD, and HC. After Z‐score normalization, ICC (≥0.75) retention, ANOVA‐FDR (P<0.05) filtering, and collinearity removal (excluding feature pairs with |r| >0.8), LASSO regression selected 7 optimal features.
Xinping Kuai, Dandan Shao, Shengyu Wang, Fangsong Zhang, Suzhen Zhang, Xuexue Wang, Jinhong Wang   +6 more
wiley   +1 more source

Neuromelanin-targeted ¹⁸F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques. [PDF]

EJNMMI Res
Feng H, Tu N, Wang K, Ma X, Zhang Z, Liu Z, Cheng Z, Bu L.   +7 more
europepmc   +1 more source

Neurodevelopmental Consequences Induced by Early‐Life Lead Exposure Through Disruption of Neurotransmitter Pathways and Molecular Mechanisms: A Systematic Review

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Lead is a toxic heavy metal with significant health risks, as maternal lead exposure during pregnancy disrupts fetal neural development through placental transfer, leading to persistent neurological, developmental, and long‐term health consequences in the progeny.
P. Harshitha, Aluru Parithathvi, Kamalesh Dattaram Mumbrekar, Herman Sunil Dsouza   +3 more
wiley   +1 more source

Intraarterial microbubble delivery enhances focused ultrasound induced blood brain barrier opening in the murine substantia nigra. [PDF]

Sci Rep
Li H, Lee YH, Zen X, Huang MW, Liu CW, Ho EP, Ou-Yang CH, Lin HI, Chen CA, Chang YY, Liu HL, Lin CH.   +11 more
europepmc   +1 more source

Neuroprotective Effects of Biosynthetic d‐Calcium Pantothenate and Cyanocobalamin Against MPTP‐Induced Parkinsonism via Microbiota Modulation, Metabolic Homeostasis Restoration, and Endoplasmic Reticulum Stress Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Biosynthetic D‐calcium pantothenate and cyanocobalamin alleviate MPTP‐induced Parkinsonism in mice by modulating gut microbiota, restoring metabolic homeostasis, and inhibiting Endoplasmic Reticulum Stress. ABSTRACT Vitamin B5 (VB5) and Vitamin B12 (VB12) are essential micronutrients widely distributed in functional foods, yet their neuroprotective ...
Yaru Chen, Shaohui Zhu, Yajie Ruan, Kaiqi Zheng, Jing Wang, Qianqian Guan, Tao Xiong   +6 more
wiley   +1 more source

GDNF receptor GFRα1 is necessary for the maintenance of dopaminergic neurons in the adult substantia nigra. [PDF]

PLoS One
Carrier-Ruiz A, Andersson A, Fernández-Suárez D, Ibáñez CF.   +3 more
europepmc   +1 more source

Modeled Long‐Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto‐Striatal‐Thalamic Circuits

Human Brain Mapping, Volume 47, Issue 10, July 2026.
We used fMRI data from a trial in psychedelic‐naïve healthy participants to show that psilocybin increases dynamic fronto‐striatal‐thalamic activity 4 weeks after dosing. Computational models revealed that reduced structure–function coupling is consistent with the emergence of increased activity dynamics, as well as increased bottom‐up and reduced top ...
Lorenzo Pasquini, Jakub Vohryzek, Anira Escrichs, Yonatan Sanz Perl, Adrian Ponce‐Alvarez, Sebastian Idesis, Manesh Girn, Leor Roseman, Jennifer M. Mitchell, Adam Gazzaley, Morten Kringelbach, David J. Nutt, Taylor Lyons, Robin L. Carhart‐Harris, Gustavo Deco   +14 more
wiley   +1 more source

Synergetic effect of a DSP4-induced locus coeruleus lesion and systemic LPS exacerbates substantia nigra dopaminergic neuron loss. [PDF]

Sci Rep
Şimşek F, Papová D, Henriksson E, Olmedo-Díaz S, Blyberg M, El-Habta R, Virel A, Af Bjerkén S.   +7 more
europepmc   +1 more source

Expanding the MRPS34 Genotype–Phenotype Correlation: Two Novel Cases and a Cohort Review

JIMD Reports, Volume 67, Issue 4, July 2026.
ABSTRACT MRPS34 encodes a mitoribosomal protein essential for mitochondrial translation. Biallelic pathogenic variants in MRPS34 cause Combined Oxidative Phosphorylation Deficiency 32 (COXPD32), a rare mitochondrial disorder within the Leigh syndrome spectrum (LSS), ranging from fatal in infancy to adult survival.
Alberte Aspaas Lundquist, Sumit Parikh, Thomas van Overeem Hansen, Flemming Wibrand, Elsebet Østergaard   +4 more
wiley   +1 more source

Evaluating Parkinson's disease biomarkers in substantia nigra following sublethal γ-radiation exposure in a large animal model. [PDF]

NPJ Parkinsons Dis
Murphy EK, Perl DP, Day RM, Iacono D.
europepmc   +1 more source