Results 191 to 200 of about 134,010 (347)

DeepRelaxo: Fast Mono‐Exponential Magnitude Brain R2* Mapping With Reduced Echoes Using Self‐Supervised Deep Learning

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose We introduce DeepRelaxo, a fast and generalizable deep learning method for estimating brain R2* maps from multi‐echo gradient echo (ME‐GRE) acquisitions with arbitrary echo configurations, including shortened echo trains for accelerated scans.
Samiha Prima, Zhuang Xiong, Alan H. Wilman, Hongfu Sun   +3 more
wiley   +1 more source

A Computational Model of Levodopa-Induced Toxicity in Substantia Nigra\n Pars Compacta in Parkinson's Disease [PDF]

, 2020
Vignayanandam Ravindernath Muddapu, Karthik Vijayakumar, Keerthiga Ramakrishnan, V. Srinivasa Chakravarthy   +3 more
openalex   +1 more source

Exercise, exerkines, and muscle–brain crosstalk in Parkinson's disease

Neuroprotection, EarlyView.
Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non‐motor symptoms, driven by dopaminergic loss and α‐synuclein accumulation. Beyond neurodegeneration, growing evidence highlights skeletal muscle health as a key determinant of prognosis, with sarcopenia and frailty contributing to greater disability, fall ...
Salomón Páez‐García, Edgar Alvarado, Alejandro Cuevas, Laura Valverde, Eduardo Salinas, Kevin O'Hara‐Veintimilla, María Cruz Rodríguez‐Oroz, Miguel Germán Borda   +7 more
wiley   +1 more source

Helicobacter pylori infection and α-synuclein pathology drive parallel neurodegenerative pathways in the substantia nigra. [PDF]

J Neuroinflammation
Soto-Avellaneda A, Prigent A, Meyerdirk L, Schautz N, Pospisilik JA, Brundin L, Henderson MX.   +6 more
europepmc   +1 more source

Transcriptional Regulation of Alpha-synuclein by GATA2 in Substantia Nigra [PDF]

, 2012
Max Horowitz
openalex  

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, EarlyView.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

Fully automated segmentation of substantia nigra toward longitudinal analysis of Parkinson's disease. [PDF]

Int J Comput Assist Radiol Surg
Hu T, Itoh H, Oda M, Saiki S, Kamagata K, Ishikawa KI, Sako W, Hattori N, Aoki S, Mori K.   +9 more
europepmc   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Glutamatergic projections from the substantia nigra pars reticulata to the dorsal raphe nucleus regulate male social hierarchies. [PDF]

PLoS Biol
Fan Y, Ge S, Lu L, Niu W, Wang Z, Jiao X, Fang G.   +6 more
europepmc   +1 more source

Glia and inflammation in the Parkinsonian substantia nigra

, 2009
Manuel B. Graeber
openalex   +1 more source