Results 181 to 190 of about 86,799 (302)

Neuropathologic basis of quantitative susceptibility mapping in the substantia nigra: contributions of tau, pigmented neurons, and iron. [PDF]

Acta Neuropathol
Ono D, Kondrakunta S, Mak E, Przybelski SA, Fought AJ, Schwarz CG, Murray ME, Nguyen A, Reichard RR, Senjem ML, Gunter JL, Jack CR, Miyagawa T, Forsberg LK, Fields JA, Savica R, Ramanan VK, Jones DT, Botha H, Louis EKS, Knopman DS, Graff-Radford NR, Day GS, Ferman TJ, Kremers WK, Lowe VJ, Petersen RC, Boeve BF, Dickson DW, Kantarci K.   +29 more
europepmc   +1 more source

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source

Neurometabolic Signatures of Alexithymia and Visuospatial Abilities in Parkinson's Disease: An Exploratory ¹H-MRS Study of the Substantia Nigra and Globus Pallidus. [PDF]

J Clin Med
Culicetto L, Marafioti G, Bonanno L, Morabito R, Fallica GE, Sorbera C, Di Lorenzo G, Marino S, Quartarone A, Ciurleo R.   +9 more
europepmc   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Preservation of Extracellular and Tissue Dopamine During Tyrosine Hydroxylase Loss in Rat 6-OHDA Parkinson's Model: Selective Compensation Restricted to Substantia Nigra. [PDF]

Int J Mol Sci
Galfano A, McManus R, Navarrete W, Chaudhari S, Bishop C, Salvatore MF.   +5 more
europepmc   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories

Journal of Anatomy, EarlyView.
The MacBrain Resource Center (MBRC) postnatal rhesus macaque brain histology datasets are organized into Collections that promote cost‐effective de novo research. This article provides examples from Collections 5, 6, and 7 and describes the histo‐ and immunohistochemical (IHC) processing of materials for Collection 6.
Valeria Mendoza‐Silva, Lucy Greene, Emma Burke, Cristina Canales, Julia Chocarro, Jose L. Lanciego, Khuleshwari Kurrey, Phil Barello, Aya Nusir, Nadine Kabbani, Kathleen S. Rockland, Dibyadeep Datta, Jon I. Arellano, Amy F. T. Arnsten, Yury M. Morozov, Bashir Ahmed, Zoltán Molnár, Caroline J. Zeiss, Pasko Rakic, Alvaro Duque   +19 more
wiley   +1 more source

Fully automated segmentation of substantia nigra toward longitudinal analysis of Parkinson's disease. [PDF]

Int J Comput Assist Radiol Surg
Hu T, Itoh H, Oda M, Saiki S, Kamagata K, Ishikawa KI, Sako W, Hattori N, Aoki S, Mori K.   +9 more
europepmc   +1 more source

DeepRelaxo: Fast Mono‐Exponential Magnitude Brain R2* Mapping With Reduced Echoes Using Self‐Supervised Deep Learning

Magnetic Resonance in Medicine, Volume 96, Issue 3, Page 1293-1302, September 2026.
ABSTRACT Purpose We introduce DeepRelaxo, a fast and generalizable deep learning method for estimating brain R2* maps from multi‐echo gradient echo (ME‐GRE) acquisitions with arbitrary echo configurations, including shortened echo trains for accelerated scans.
Samiha Prima, Zhuang Xiong, Alan H. Wilman, Hongfu Sun   +3 more
wiley   +1 more source

Neuromodulatory Effects of Substantia Nigra Pars Reticulata Deep Brain Stimulation (SNr-DBS) in the 6-Hydroxydopamine Rat Model of Parkinson's Disease. [PDF]

Medicina (Kaunas)
Turgut E, Parlak H, Eser P, Temel Y, Jahanshahi A, Sarıkcıoglu L, Tanrıover GE, Ucar T, Kocabicak E, Agar A.   +9 more
europepmc   +1 more source

Organization of Astrocytic GLT‐1 at Cortical Inhibitory Synapses

Glia, Volume 74, Issue 8, August 2026.
GLT‐1+ ALs frequently juxtapose symmetric synapses. Distance‐based phenotyping identifies symmetric‐ and asymmetric‐associated GLT‐1+ ALs. Distal inhibitory synapses show enriched GLT‐1/α2 couples in ALs within 1000 nm, conserved in human cortex. ABSTRACT Glutamate spillover from excitatory synapses modulates neighboring inhibitory synapses, yet the ...
Marcello Melone, Michael Di Palma, Annalisa Scimemi, Fiorenzo Conti   +3 more
wiley   +1 more source