Results 181 to 190 of about 73,544 (253)

Context‐dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Divergent triggering receptor expressed on myeloid cells 2 (TREM2) signalling pathways instruct myeloid cell adaptation towards neuroprotective disease‐associated microglia (DAM)/lipid‐associated macrophage (LAM) or immunosuppressive tumour‐associated macrophage (TAM) phenotypes.
Yaqing Lv, Mingpeng Shi, Yongfei Zhao, Yi Yu, Jiawei Lv, Hai Zhao   +5 more
wiley   +1 more source

Preservation of Extracellular and Tissue Dopamine During Tyrosine Hydroxylase Loss in Rat 6-OHDA Parkinson's Model: Selective Compensation Restricted to Substantia Nigra. [PDF]

Int J Mol Sci
Galfano A, McManus R, Navarrete W, Chaudhari S, Bishop C, Salvatore MF.   +5 more
europepmc   +1 more source

Trigonelline Alleviates Neuroinflammation in AAV‐SynA53T Parkinson's Disease Model Mice: Involvement of PI3K/AKT–NF‐κB Signaling and Gut Microbial‐Metabolic Remodeling

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Trigonelline alleviated motor deficits, α‐synuclein‐associated pathology, and neuroinflammatory changes in AAV‐SynA53T mice. These effects were accompanied by reduced PI3K/AKT–NF‐κB signaling activity, improved intestinal barrier‐associated features, and gut microbiota–metabolome remodeling.
Mozi Chen, Yiyao Dong, Jie Zheng, Yan Lin, Qiyao Li, Chuhua Wei, Linpei Zhuo, Yan He, Jing Sun, Feng Fu, Jiaming Liu   +10 more
wiley   +1 more source

Neurometabolic Signatures of Alexithymia and Visuospatial Abilities in Parkinson's Disease: An Exploratory ¹H-MRS Study of the Substantia Nigra and Globus Pallidus. [PDF]

J Clin Med
Culicetto L, Marafioti G, Bonanno L, Morabito R, Fallica GE, Sorbera C, Di Lorenzo G, Marino S, Quartarone A, Ciurleo R.   +9 more
europepmc   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, Volume 5, Issue 5, Page 495-513, October 2026.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Helicobacter pylori infection and α-synuclein pathology drive parallel neurodegenerative pathways in the substantia nigra. [PDF]

J Neuroinflammation
Soto-Avellaneda A, Prigent A, Meyerdirk L, Schautz N, Pospisilik JA, Brundin L, Henderson MX.   +6 more
europepmc   +1 more source

Microplastics as Emerging Neurotoxins: Brain Accumulation, Neuroinflammation, and Neurodegeneration Risk

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Microplastics and nanoplastics (MPs/NPs) are emerging environmental neurotoxicants capable of accumulating in the human brain through blood‐brain barrier transcytosis and olfactory transport pathways. Once within the central nervous system, MPs/NPs trigger interconnected mechanisms including NLRP3 inflammasome activation, oxidative stress ...
Alfi Sophian, Asmariani, Erika Ismayani
wiley   +1 more source

Substantia Nigra as Brainstem Signature in Pediatric-Onset Huntington's Disease: The RAREST-JHD Study. [PDF]

Mov Disord Clin Pract
Sabatini U, Maffi S, Caligiuri ME, Sánchez-Castañeda C, Tinelli E, Squitieri F.   +5 more
europepmc   +1 more source

Neuromodulatory Effects of Substantia Nigra Pars Reticulata Deep Brain Stimulation (SNr-DBS) in the 6-Hydroxydopamine Rat Model of Parkinson's Disease. [PDF]

Medicina (Kaunas)
Turgut E, Parlak H, Eser P, Temel Y, Jahanshahi A, Sarıkcıoglu L, Tanrıover GE, Ucar T, Kocabicak E, Agar A.   +9 more
europepmc   +1 more source

Correlates of head-fixed directional forelimb movements in mouse superior colliculus and substantia nigra pars reticulata. [PDF]

Neuroscience
Doykos TK, Yamauchi T, Buteau A, Hanson S, Dudman JT, Felsen G, Stubblefield EA.   +6 more
europepmc   +1 more source