Results 171 to 180 of about 73,544 (253)

Progressive Cognitive Decline and Pyramidal Signs in a Patient With a Novel Homozygous c.395A>T; p.Lys132Met Mutation in CHCHD2

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Biallelic CHCHD2 variants are rare. We report a consanguineous man with a novel homozygous CHCHD2 c.395A>T (p.Lys132Met) variant who developed progressive cognitive decline, apraxia, oculomotor impairment, and pyramidal signs without parkinsonism.
Mehri Salari, Arash Soltani, Masoud Etemadifar, Kamran Rezaei   +3 more
wiley   +1 more source

Giving you five: A neuroimaging atlas of the nigrosomes in the substantia nigra based on 3D histology

Brammerloh M, Alkemade A, Bazin P, Jantzen C, Jäger C, Herrler A, Pine KJ, Morawski M, Balesar R, Amunts K, Forstmann BU, Weiskopf N, Kirilina E.   +12 more
europepmc   +1 more source

Advances in Peptide‐Targeted Fluorescent Probes for the Diagnosis and Therapy of Brain Disorders

ChemistryEurope, Volume 4, Issue 10, October 2026.
This review summarizes peptide‐based fluorescent probes for major brain diseases, such as Alzheimer's and Parkinson's. It highlights their precise biomarker targeting and high sensitivity for imaging pathological processes in vivo. These probes also show great potential for enabling theranostic applications, thereby offering real‐time monitoring and ...
Shuangjing Yang, Yuting Wang, Yongkang Yue, Fangjun Huo, Caixia Yin   +4 more
wiley   +1 more source

Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease. [PDF]

Genome Res
Wang K, Xia W, Gu Y, Zu S, Yang Q, Amaral ML, Wang Y, Wang A, Fu XD, Mobley WC, Ren B.   +10 more
europepmc   +1 more source

Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This review summarizes potential functions of platelet factor 4 (PF4) in neurodegenerative diseases (NDs) and discusses its promise as both a biomarker and a therapeutic target. Further elucidation of PF4 signaling pathways may provide new insights into disease mechanisms and uncover novel opportunities for targeted interventions in NDs.
Qi Tian, Yanji Tong, Fang Yu, Xiaoming Hu   +3 more
wiley   +1 more source

Brain‐Wide Connectivity and Topographic Organization of Leptin Receptor Neurons in the Dorsomedial Hypothalamus

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Whole‐brain input–output mapping reveals that DMDLepRb and DMHLepRb neurons share a highly conserved global connectivity architecture yet exhibit local connection biases: DMDLepRb neurons preferentially integrate arousal and defensive signals, whereas DMHLepRb neurons favor viscerosensory and metabolic inputs, uncovering a principle of conserved global
Yaxin Hao, Xiang Zhang, Danyang Zhao, Haixing Zhong, Yongqiang Chen, Heming Li, Minghui Ren, Mengchu Zhu, Fang Yuan   +8 more
wiley   +1 more source

Neuropathologic basis of quantitative susceptibility mapping in the substantia nigra: contributions of tau, pigmented neurons, and iron. [PDF]

Acta Neuropathol
Ono D, Kondrakunta S, Mak E, Przybelski SA, Fought AJ, Schwarz CG, Murray ME, Nguyen A, Reichard RR, Senjem ML, Gunter JL, Jack CR, Miyagawa T, Forsberg LK, Fields JA, Savica R, Ramanan VK, Jones DT, Botha H, Louis EKS, Knopman DS, Graff-Radford NR, Day GS, Ferman TJ, Kremers WK, Lowe VJ, Petersen RC, Boeve BF, Dickson DW, Kantarci K.   +29 more
europepmc   +1 more source

Impacts of Cognitive Load and Task Initiation Timing on Gait Performance in Parkinson's Disease: A Dual‐Task Paradigm Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In patients with Parkinson's disease, gait was most impaired when a demanding cognitive task was initiated before walking rather than after, with reduced lower‐limb coordination under the same condition. The order of task initiation, not merely dual‐tasking itself, shapes gait vulnerability.
Shohei Okusa, Takehide Kimura, Kenya Tanamachi, Fuminari Kaneko, Yuka Yamada, Michiyuki Kawakami, Jin Nakahara, Morinobu Seki   +7 more
wiley   +1 more source

Fully automated segmentation of substantia nigra toward longitudinal analysis of Parkinson's disease. [PDF]

Int J Comput Assist Radiol Surg
Hu T, Itoh H, Oda M, Saiki S, Kamagata K, Ishikawa KI, Sako W, Hattori N, Aoki S, Mori K.   +9 more
europepmc   +1 more source

ALDH1A1-dopaminergic gene co-expression in human substantia nigra: meta-analysis of disease-associated correlation changes across seven independent Parkinson's disease datasets. [PDF]

Front Aging Neurosci
Harbert DH.
europepmc   +1 more source