Results 161 to 170 of about 73,544 (253)

Synaptic integration and competition in the substantia nigra pars reticulata-An experimental and in silico analysis. [PDF]

Proc Natl Acad Sci U S A
Thompson WS, Hjorth JJJ, Kozlov A, Thunberg W, Silberberg G, Hellgren Kotaleski J, Grillner S.   +6 more
europepmc   +1 more source

Cognitive impairment in Parkinson disease correlates with loss of cholinergic axon projections to cortex in an autopsy study

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION People with Parkinson's disease (PD) frequently develop dementia. We investigated the relationship between cognitive impairment and the loss of cholinergic axon projections from the nucleus basalis of Meynert to neocortical regions in PD.
Rebecca Miller, Jennifer O'Shea, Laura M. Rosok, Sydney Lim, Erin E. Franklin, Richard J. Perrin, Helen Hwang, Dhruva Dhavale, Joel Perlmutter, Meghan C. Campbell, Paul Kotzbauer   +10 more
wiley   +1 more source

Deciphering MMRN1 diagnostic and therapeutic implications in the substantia nigra of Parkinson's disease patients via integrative bioinformatic analysis and multi-omics studies. [PDF]

Front Aging Neurosci
Ning Y, Gao W, Gao Y.
europepmc   +1 more source

Regional and Compartmental Changes Drive Progressive Patterns of Striatal Degeneration in X‐Linked Dystonia Parkinsonism

Annals of Neurology, Volume 100, Issue 4, Page 751-767, October 2026.
Objective Initially described in 1976, X‐linked dystonia parkinsonism (XDP) is a neurodegenerative disease that can be characterized by the presentation of dystonia and parkinsonism symptoms. Although this disease bears some resemblance to other neurodegenerative diseases in terms of symptomatology, the pathological signature of XDP is still unclear ...
Adelie Y.S. Tan, Nakhon. S.S.S. Thai, Christine J. Arasaratnam, Seung A. Han, Ellen B. Penney, Geraldine Acuña‐Sunshine, Cid Czarina E. Diesta, Mark C. Ang, Edwin Muñoz, Cara Fernandez‐Cerado, Victor Cleofas, G. Paul Legarda, Salvie Velasco, Michelle A. Sy, Clinton P. Turner, Mike Dragunow, Maurice A. Curtis, Ann. M. Graybiel, Richard L.M. Faull, Malvindar K. Singh‐Bains   +19 more
wiley   +1 more source

Protective Effects of a Cissus quadrangularis Stem Peel Ash Derived Salt Against Streptozotocin Induced Cellular Injury in SH‐SY5Y Cells

Applied Research, Volume 5, Issue 5, October 2026.
Cissus quadrangularis stem peel‐derived bio salt protects SH‐SY5Y neuroblastoma cells against streptozotocin‐induced neurotoxicity by reducing oxidative stress, suppressing apoptosis, and improving cell viability. These findings highlight its potential as a natural neuroprotective agent for neurodegenerative disorders.
Panimalar Thirupathi Brindhavanam, Ramasamy Mahadevi, Veeran Sethuraman, Manickam Rajkumar, Kavitha Ramamoorthy   +4 more
wiley   +1 more source

Age-related susceptibility to paraquat-induced neurotoxicity in male wistar rats: effects on neurobehaviour, substantia nigra cytoarchitecture, and alpha-synuclein levels. [PDF]

BMC Neurosci
Ichie K, Asomugha A, Okafor I.
europepmc   +1 more source

Altered Inter‐Network Functional Integration Underlies Speech Impairment in Parkinson's Disease: A Resting‐State fMRI Analysis

Brain and Behavior, Volume 16, Issue 10, October 2026.
Resting‐state functional magnetic resonance imaging and independent component analysis were used to compare large‐scale functional network connectivity among patients with Parkinson's disease with speech disorders (PD‐SD, n = 62), patients without speech disorders (PD‐NON‐SD, n = 16), and healthy controls (HC, n = 36).
Shan Deng, Yongqing Xiao, Zimei Dong, Cai Zhong, Yu Yu, Chunxiao Yang, Liya Pan, Baohui Weng, Yuan Chen, Ziming Ye, Ying Liu, Chao Qin   +11 more
wiley   +1 more source

Exploring the Neuropharmacological Potential of Ligustrum sinense Relevant to Parkinson's Disease: In Vivo and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Ligustrum sinense (L. sinense) leaf extract exhibited moderate antioxidant activity (DPPH IC50 = 73.56 ± 2.18 µg/mL) and was evaluated for neuropharmacological effects at 200 and 400 mg/kg using elevated plus maze, open‐field, hole‐cross, and hole‐board tests.
Sowmitro Das, S. M. Istiaque Hamim, Md Nazmul Hasan Zilani, Kazi Sneha Chhando, Puza Das, Md Ridoy Hossain, Md. Imtiaz, Jebin Tasmin, Roney Miah, Md. Nazmul Hasan   +9 more
wiley   +1 more source

A nomogram combined substantia nigra hyperechogenicity with third ventricular width assessed by transcranial sonography in prediction Parkinson's disease-related cognitive impairment. [PDF]

BMC Med Imaging
Yang QH, Hou C, Li MX.
europepmc   +1 more source