Results 161 to 170 of about 86,799 (302)

Sustained activity of human substantia nigra neurons reflect prior rewards. [PDF]

iScience
Imtiaz Z, Kato A, Kopell BH, Qasim SE, Davis AN, Martinez LN, Heflin M, Kulkarni K, Morsi A, Charney AW, Gu X, Saez I.   +11 more
europepmc   +1 more source

Qihuang Needle Therapy for Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

Movement Disorders, EarlyView.
Abstract Background Motor symptoms in Parkinson's disease (PD) often respond incompletely to medication, highlighting the need for effective adjunctive therapies. Acupuncture may offer benefits, but high‐quality evidence for specialized techniques such as Qihuang needle therapy is lacking.
Wanqing Peng, Renhui Zhao, Ziting Huang, Jingpei Zhou, Yanning Liu, Zhijuan Liu, Xinyu Li, Jingjing Deng, Xubo Hong, Yanfang Chen, Nanbu Wang, Zhenhu Chen   +11 more
wiley   +1 more source

Defining a role for the peduncolopontine tegmental nucleus in striatal outflow

, 2012
The pedunculopontine tegmental nucleus (PPTg) lies within the pontomesencephalon and contains cholinergic and non-cholinergic neurones. It has extensive afferent and efferent connections throughout the brain.
Allen, Laura F.
core  

Expression of Axonal Transport Proteins in Dopaminergic Neurons of the Substantia Nigra in Mouse Models of Preclinical and Clinical Stages of Parkinson's Disease. [PDF]

Int J Mol Sci
Kolacheva A, Troshev D, Antonova A, Pavlova E, Bogdanov V, Kalashnikova V, Popova A, Shchepina M, Ugrumov M.   +8 more
europepmc   +1 more source

Gray Matter Microstructure Measured Using Diffusion Imaging as a Biomarker of Severity in Lewy Body Diseases

Movement Disorders, EarlyView.
Abstract Background Despite widespread cortical involvement in Lewy body diseases, conventional gray matter magnetic resonance imaging (MRI) shows limited sensitivity. Diffusion‐weighted MRI‐derived microstructural measures have shown utility in Alzheimer's disease, but their application across the Lewy body disease spectrum remains limited ...
Angeliki Zarkali, Ivelina Dobreva, Naomi Hannaway, Rohan Bhome, George E.C. Thomas, Steffani Carrera, Amanda J. Heslegrave, Elena Veleva, Henrik Zetterberg, Rimona S. Weil   +9 more
wiley   +1 more source

Predominance of Ferroptotic Cell Death Mechanisms in Substantia Nigra Neurodegeneration in Parkinson's Disease. [PDF]

Ann Neurol
Heng YJ, Jayaraman A, Reynolds R, Foo JN.   +3 more
europepmc   +1 more source

Transcranial Pulse Stimulation Enhances Dexterity in Parkinson's Disease: A Randomized Sham‐Controlled Trial

Movement Disorders, EarlyView.
Abstract Background Ultrasound‐based neuromodulation, capable of reaching deep brain areas with high precision, represents cutting‐edge technology in non‐invasive brain stimulation and is investigated as a novel treatment for neurological and psychiatric disorders, including Parkinson's disease (PD).
Eva Matt, Nina Plischek, Michael Mitterwallner, Sonja Radjenovic, Alexandra Weber, Alina Domitner, Gregor Dörl, Anna Zettl, Sarah Osou, Anna Leitgeb, Agnes Santer, Viktoria Winkler, Julia Mandelburger, Heidemarie Zach, Roland Beisteiner   +14 more
wiley   +1 more source

Machine learning-based optimization of dual subthalamic nucleus and substantia nigra targeting in deep brain stimulation. [PDF]

NPJ Parkinsons Dis
Leavitt D, Negahbani F, Gharabaghi A.
europepmc   +1 more source

Observations on an Open‐Label Phase 1/2 Dopamine Gene Therapy Trial (OXB‐102/Axo‐Lenti‐PD) in People with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background SUNRISE‐PD was a dose‐escalating, phase 1/2 study investigating a second‐generation lentiviral vector gene therapy delivering the genes for dopamine synthesis (OXB‐102) to treat Parkinson's disease (PD). The trial was prematurely terminated due to insolvency of the sponsor.
Simon Rowe, Amy Evans, Saeed Kayhanian, Philip C. Buttery, Robert Morris, Katie Andresen, Laura Sherlock, Samuel Hewitt, Tagore Nakornchai, Marwan Hariz, Kyriacos Mitrophanous, Ludvic Zrinzo, Matthew Appleby, Phil Woodgate, Seema Maru, Patricia Limousin, Christine Girges, Thomas Foltynie, Stephane Palfi, Roger A. Barker   +19 more
wiley   +1 more source

Synaptic integration and competition in the substantia nigra pars reticulata-An experimental and in silico analysis. [PDF]

Proc Natl Acad Sci U S A
Thompson WS, Hjorth JJJ, Kozlov A, Thunberg W, Silberberg G, Hellgren Kotaleski J, Grillner S.   +6 more
europepmc   +1 more source