Results 271 to 280 of about 133,054 (344)

AAV‐PHP.eB Peripheral Delivery and Central Expression in Cre Mice

Journal of Comparative Neurology, Volume 534, Issue 1, January 2026.
Retro‐orbital injection of AAV‐PHP.eB‐FLEX‐tdTomato into four different strains of Cre mice produced various and distinct patterns of transduction efficiency and tropism across brain regions and cell types. We found many target neurons expressing tdTomato in most but not all strains, along with a low level of nonspecific (Cre‐independent) expression ...
Haidong Zhu, Joel C. Geerling
wiley   +1 more source

Efficacy and safety assessment of homotopical transplantation of iPSCs-derived midbrain organoids into the substantia nigra of Parkinsonian rats. [PDF]

Bioeng Transl Med
Zheng X, Chen J, Huang Z, Zhang Y, Zhou L.   +4 more
europepmc   +1 more source

Engineering Liposomes for Neurodegenerative Diseases: Targeted Delivery and Regenerative Potential

ChemNanoMat, Volume 12, Issue 1, January 2026.
Liposomal nanocarriers offer therapeutic promise for neurodegenerative diseases by encapsulating diverse agents such as neurotrophic factors and mRNA while targeting the blood‐brain barrier. Designed to stimulate neuronal repair and restore function, these lipid vesicles advance strategies for optimized design and central nervous system delivery ...
Oybek Ashirov, Shakhnoz Azimova, Borislav Angelov, Angelina Angelova   +3 more
wiley   +1 more source

Interactions of Oligodendrocyte Precursor Cells and Dopaminergic Neurons in the Mouse Substantia Nigra. [PDF]

J Neurochem
Fitzgerald JC, Sun Y, Reinecke F, Bauer E, Garaschuk O, Kahle PJ, Pfeiffer F.   +6 more
europepmc   +1 more source

Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pitolisant, an FDA‐approved H3R antagonist, counteracts the rewarding and sedative effects of ethanol, reduces alcohol intake, and alleviates the negative affect during withdrawal. This might occur via the antagonism of presynaptic autoreceptors and heteroreceptors H3Rs in the lateral habenula, thereby activating the H2R/p‐CREB/BDNF signaling and ...
Yan Zhao, Yixin Fu, Tianhao Liu, Zanhao Yang, Zhengzhong Yang, Bingqing Chen, Lipeng Zhou, Juntao Yang, Duo Chen, Xiaojiao Han, Ying Tang, Jiang‐Hong Ye, Chao‐Yu Miao, Rao Fu   +13 more
wiley   +1 more source

Systemic Primary Carnitine Deficiency Presenting With Substantia Nigra and Basal Ganglia Injury: A Case Report. [PDF]

JIMD Rep
Saito T, Soma K, Kashisaka M, Iketani K, Matsumoto M, Ueda T, Nishiyama M, Maruyama A, Nakai R, Sakihama H, Kurosawa H, Morisada N, Kobayashi H, Ozaki K.   +13 more
europepmc   +1 more source

Exploring the Fecal Microbiome Dysbiosis and Its Plasma Metabolome Determinants in Advanced Parkinson's Disease With Motor Complications

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Our multiomics analysis across three PD cohorts revealed distinct fecal microbiome and plasma metabolome alterations in patients with motor complications (PD‐MC). We identified specific microbial and metabolic biomarkers and uncovered significant correlations between them, providing new insights into PD‐MC pathophysiology. ABSTRACT Background Parkinson'
Shuangjie Qian, Jialong Hou, Xi Xiong, Qi Duan, Tao Jiang, Yi Zheng, Weiwei Quan, Jiaxue Xu, Keke Chen, Jingjing Qian, Hongchang Gao, Chenglong Xie   +11 more
wiley   +1 more source

Short-term modulation of inferior colliculus (IC)-substantia nigra compacta (SNc) circuit affects motor deficits induced by acute noise exposure in 6-hydroxydopamine mice.

Chi Cui (10201007), Yibo Yao (16274454), Yulong Shi (459712), Jie Lei (579923), Kun Ren (6173954), Kexing Wan (6258182), Tongxia Li (13354935), Gangan Luo (16999848), Qian Xu (119888), Ming Li (91180), Xiang Peng (3092073), Xueke Yang (14648669), Jian Yang (12136), Junsong Du (22559804), Sitong Chen (170590), Bo Tian (625365), Pei Zhang (232846)   +16 more
openalex   +1 more source

Anti‐Neuroinflammation Activity of Essential Oils and Fatty Acids

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Neuroinflammation plays a pivotal role in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). Current pharmacological interventions, such as NSAIDs and corticosteroids, are limited by systemic toxicity and insufficient efficacy in targeting chronic neuroinflammatory processes.
Zelong Jin, Yige Song, Ahmed Attia Ahmed Abdelmoaty, Feng Lin, Jiujun Li, Xianyang Chen   +5 more
wiley   +1 more source

Effect of nicotine on the energy metabolism of substantia nigra cells in MPTP-induced Parkinson's disease. [PDF]

Iran J Basic Med Sci
Zhgenti N, Bibilashvili O, Shengelia M, Burjanadze G, Koshoridze M, Davitashvili E, Koshoridze N.   +6 more
europepmc   +1 more source