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A deep cellular atlas of the human ventral substantia nigra in Parkinson’s identifies a genetic and molecular overlap with Type 2 Diabetes

open access: yes
Volpato V   +17 more
europepmc   +1 more source
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Neuromelanin of the Human Substantia Nigra: An Update

Neurotoxicity Research, 2013
Dopaminergic neurons of the substantia nigra selectively degenerate over the course of Parkinson's disease. These neurons are also the most heavily pigmented cells of the brain, accumulating the dark pigment neuromelanin over a lifetime. The massive presence of neuromelanin in these brain areas has long been suspected as a key factor involved in the ...
Fabio A Zucca   +2 more
exaly   +4 more sources

Diagnostic evaluation of the substantia nigra

Neuropathology and Applied Neurobiology, 1996
An improved method for the histopathological evaluation of the substantia nigra for diagnostic purposes is proposed. This method takes advantage of the natural architecture of the constituent cell clusters of the substantia nigra by combining standardized sections in the horizontal plane and simple quantification. The use of this standardized technique
McRitchie Da   +3 more
openaire   +3 more sources

Dopamine release in substantia nigra?

Nature, 1976
IN addition to the axons which project to the nucleus caudatus1,2, the dopamine (DA)-containing perikarya of the substantia nigra have extensive dendritic processes. These dendrites, observed after Golgi staining3–5 and by electron microscopy3,4, contain relatively large amounts of DA—revealed by histofluorescence6—and vesicle–like structures4.
Jakob Korf   +2 more
openaire   +4 more sources

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