Substantia nigra - Open Access .click

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On the question of apoptosis in the parkinsonian substantia nigra

Acta Neuropathologica, 1997
Apoptosis has been postulated as a mechanism of nerve cell death in Parkinson's disease. In the present study, the substantia nigra of 22 neuropathologically confirmed Parkinson cases and 8 control brains was studied using the in situ end-labeling (TUNEL) method.
U. von Eitzen +4 more
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Neurogenesis in Substantia Nigra of Parkinsonian Brains?

2009
The clinical motor dysfunction in Parkinson's disease is primarily the consequence of a progressive degeneration of dopaminergic neurons in the substantia nigra of the nigrostriatal pathway. The degeneration of this tract provokes a depletion of dopamine in the striatum, where it is required as a permissive factor for normal motor function.
Wolfgang H. Oertel +10 more
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The Substantia Nigra Pars Reticulata

2016
The GABAergic projection neurons are the main neuron type in the substantia nigra pars reticulata (SNr). A striking feature of these SNr GABA neurons is that they fire sustained, spontaneous high frequency spikes and thus tonically inhibit their targets.
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Substantia nigra Efferent Connections