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Cytoarchitecture of the substantia nigra in the rat
American Journal of Anatomy, 1970AbstractMidbrains of ten young adult rats were sectioned serially in three planes to study the detailed cytoarchitecture of the substantia nigra. These neurons measure 8 to 17 μ in diameter. In comparison, the largest neurons in the midbrain measure 20 to 40 μ; hence, neurons are designated according to size as follows: those measuring 18 to 40 μ ...
Martin G. Netsky +2 more
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The neuromelanin of the human substantia nigra
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1991The pigment of the human substantia nigra was isolated after extraction of lipids and proteins with 2% sodium cholate in 30% ethanol followed by 2% sodium dodecyl sulfate in 10% glycerol. The pigment was hydrolysed with HI or degraded by treatment with KMNO4 and the samples were examined for compounds known to derive from pheomelanin (4-amino-3 ...
Hans Rorsman +4 more
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Innervation of the substantia nigra
Cell and Tissue Research, 2004This review describes inputs to neurons in the substantia nigra and contrasts them with the action of agonists for the putative receptors through which they act. Special emphasis is placed on gamma-aminobutyric acid (GABA) afferents. Dopamine released from the somato-dendritic compartment of dopamine neurons and endocannabinoids released from dopamine ...
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Substantia Nigra Hyperactivity in Schizophrenia
Biological Psychiatry, 2013Mapping the clinical features of schizophrenia to circuits in the brain is a major goal for schizophrenia researchers. The prefrontal cortex (PFC), the ventral midbrain, and the striatum are among the brain areas of primary interest. The PFC has been linked to cognitive deficits, especially impairment of working memory.
Stephan Heckers, Christine Konradi
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Substantia Nigra and Parkinsonism
Archives of Neurology, 1964The opinion that parkinsonism is caused by damage of the substantia nigra was advanced by Brissaud 1 on the basis of the findings in a case of Charcot's studied by Bechet 2 and Blocq and Marinesco. 3 In a series of 54 autopsies Tretiakoff 4 found the substantia nigra degenerated in 16 categories of neurologic disorder including three cases of ...
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The substantia nigra and stereotyped behaviour
European Journal of Pharmacology, 1972Abstract The acute and chronic effects of bilateral lesions of the substantia nigra upon amphetamine- and apomorphine-induced stereotyped behaviour and its modification by haloperidol and arecoline were studied in the rat. A mild spontaneous stereotyped behaviour was observed during the acute stage following the induction of nigral lesions. In order
Brenda Costall +2 more
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Neuropathology of the Substantia nigra
European Neurology, 1991Neuronal subpopulations of the substantia nigra pars compacta can be separated into two functionally distinct nigrostriatal projections, the ventral tier which is poorly melanised, and the dorsal tier which is well melanised. In Parkinson's disease, juvenile-onset parkinsonism with dystonia and striatonigral degeneration the ventral tier is more ...
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Synapses in the rat substantia nigra
Tissue and Cell, 1971The composition and organization of the input to the rat substantia nigra were studied with the electron microscope. Four distinct types of synaptic boutons were described. The first contained small (381 A), clear synaptic vesicles. The second type contained the small, clear vesicles and several large, dense-core vesicles.
Robert L. Gulley, Morris Smithberg
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The role of GABA in the substantia nigra
Nature, 1978STRIATONIGRAL GABAergic fibres are widely believed to exert a tonic inhibitory influence on the dopamine (DA)-containing cells of the substantia nigra (SN), and contraversive and ipsiversive circling behaviour can be explained in terms of a greater or lesser activity of the dopaminergic neurones, respectively1,2. However, the blockade of γ-aminobutyric
T. A. James, M. S. Starr
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Evidence for autapses in the substantia nigra
Brain Research, 1980Intracellular recording and intracellular HRP staining were employed to trace the recurrent terminal plexus of cat substantia nigra pars reticulata neurons. Autaptic neurons were labeled. The axon of an autaptic neuron was found to emit a recurrent collateral which distributed 'en passage' and terminal boutons contacting dendrites of the parent cell ...
Athanasios B. Karabelas +1 more
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