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Neurology, 2021
A 20-year-old man without medical history but with septic shock developed neuroleptic malignant syndrome after being treated with loxapine for delirium. He had been admitted to the intensive care unit 2 weeks earlier for septic shock. An MRI done 27 days
F. Lersy, H. Merdji
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A 20-year-old man without medical history but with septic shock developed neuroleptic malignant syndrome after being treated with loxapine for delirium. He had been admitted to the intensive care unit 2 weeks earlier for septic shock. An MRI done 27 days
F. Lersy, H. Merdji
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A common hub for sleep and motor control in the substantia nigra
Science, 2020Interneurons control brain arousal states The underlying circuit mechanisms coordinating brain arousal and motor activity are poorly understood. Liu et al.
Danqian Liu +12 more
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Ageing and Parkinson's disease: substantia nigra regional selectivity.
Brain : a journal of neurology, 1991The micro-architecture of the substantia nigra was studied in control cases of varying age and patients with parkinsonism. A single 7 mu section stained with haematoxylin and eosin was examined at a specific level within the caudal nigra using strict ...
J. Fearnley, A. J. Lees
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Diagnostic evaluation of the substantia nigra
Neuropathology and Applied Neurobiology, 1996An improved method for the histopathological evaluation of the substantia nigra for diagnostic purposes is proposed. This method takes advantage of the natural architecture of the constituent cell clusters of the substantia nigra by combining standardized sections in the horizontal plane and simple quantification. The use of this standardized technique
McRitchie Da +3 more
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Dopamine release in substantia nigra?
Nature, 1976IN addition to the axons which project to the nucleus caudatus1,2, the dopamine (DA)-containing perikarya of the substantia nigra have extensive dendritic processes. These dendrites, observed after Golgi staining3–5 and by electron microscopy3,4, contain relatively large amounts of DA—revealed by histofluorescence6—and vesicle–like structures4.
Jakob Korf +2 more
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Cytoarchitecture of the substantia nigra in the rat
American Journal of Anatomy, 1970AbstractMidbrains of ten young adult rats were sectioned serially in three planes to study the detailed cytoarchitecture of the substantia nigra. These neurons measure 8 to 17 μ in diameter. In comparison, the largest neurons in the midbrain measure 20 to 40 μ; hence, neurons are designated according to size as follows: those measuring 18 to 40 μ ...
Martin G. Netsky +2 more
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The neuromelanin of the human substantia nigra
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1991The pigment of the human substantia nigra was isolated after extraction of lipids and proteins with 2% sodium cholate in 30% ethanol followed by 2% sodium dodecyl sulfate in 10% glycerol. The pigment was hydrolysed with HI or degraded by treatment with KMNO4 and the samples were examined for compounds known to derive from pheomelanin (4-amino-3 ...
Hans Rorsman +4 more
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Substantia Nigra Hyperactivity in Schizophrenia
Biological Psychiatry, 2013Mapping the clinical features of schizophrenia to circuits in the brain is a major goal for schizophrenia researchers. The prefrontal cortex (PFC), the ventral midbrain, and the striatum are among the brain areas of primary interest. The PFC has been linked to cognitive deficits, especially impairment of working memory.
Stephan Heckers, Christine Konradi
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Innervation of the substantia nigra
Cell and Tissue Research, 2004This review describes inputs to neurons in the substantia nigra and contrasts them with the action of agonists for the putative receptors through which they act. Special emphasis is placed on gamma-aminobutyric acid (GABA) afferents. Dopamine released from the somato-dendritic compartment of dopamine neurons and endocannabinoids released from dopamine ...
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