Results 21 to 30 of about 133,054 (344)

A prospective longitudinal study of perceived infant outcomes at 18-24 months: Neural and psychological correlates of parental thoughts and actions assessed during the first month postpartum [PDF]

open access: yes, 2015
The first postpartum months constitute a critical period for parents to establish an emotional bond with their infants. Neural responses to infant-related stimuli have been associated with parental sensitivity.
Cole, Pamela M.   +6 more
core   +2 more sources

Striatal Infarction in the Rat Causes a Transient Reduction of Tyrosine Hydroxylase Immunoreactivity in the Ipsilateral Substantia Nigra

open access: yesNeurobiology of Disease, 1997
Dopaminergic neurons of the substantia nigra pars compacta were examined in the rat brain following striatal infarction subsequent to transient focal cerebral ischemia.
Marc A. Soriano   +4 more
doaj   +1 more source

Ontogeny of synaptophysin and synaptoporin in the central nervous system [PDF]

open access: yes, 1993
The expression of the synaptic vesicle antigens synaptophysin (SY) and synaptoporin (SO) was studied in the rat striatum, which contains a nearly homogeneous population of GABAergic neurons. In situ hybridization revealed high levels of SY transcripts in
B. Marquèze-Pouey   +36 more
core   +1 more source

Microstructural changes within the basal ganglia differ between Parkinson disease subtypes

open access: yesFrontiers in Neuroanatomy, 2016
Diffusion tensor imaging (DTI) of the substantia nigra has shown promise in detecting and quantifying neurodegeneration in Parkinson disease (PD). It remains unknown, however, whether differences in microstructural changes within the basal ganglia ...
Lidia M Nagae   +6 more
doaj   +1 more source

Discovery of noncanonical translation initiation sites through mass spectrometric analysis of protein N termini [PDF]

open access: yes, 2017
Translation initiation generally occurs at AUG codons in eukaryotes, although it has been shown that non-AUG or non-canonical translation initiation can also occur.
Barbhuiya, Mustafa   +10 more
core   +1 more source

The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis. [PDF]

open access: yesPLoS ONE, 2010
BACKGROUND: The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences of injections of 3,4-dihydroxyphenylacetaldehyde (DOPAL), a toxic metabolite of dopamine, into the substantia nigra of rats on motor behavior ...
W Michael Panneton   +4 more
doaj   +1 more source

DIFFERENTIALLY EXPRESSED GENES AND THEIR SIGNIFICANCE THE SUBSTANTIA NIGRA OF MICE WITH 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED PARKINSON’S DISEASE [PDF]

open access: yes精准医学杂志, 2023
Objective To investigate the differentially expressed genes (DEGs) in the substantia nigra of mice with Parkinson’s disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) based on bioinformatics, as well as their role in the ...
LI Beining, YAO Zhengyang, JIAO Qian, CHEN Xi, JIANG Hong, DU Xixun
doaj   +1 more source

Environmental Exposures and Parkinson's Disease. [PDF]

open access: yes, 2016
Parkinson's disease (PD) affects millions around the world. The Braak hypothesis proposes that in PD a pathologic agent may penetrate the nervous system via the olfactory bulb, gut, or both and spreads throughout the nervous system. The agent is unknown,
Litvan, Irene, Nandipati, Sirisha
core   +2 more sources

Chemical Exchange Saturation Transfer MRI Signal Loss of the Substantia Nigra as an Imaging Biomarker to Evaluate the Diagnosis and Severity of Parkinson's Disease

open access: yesFrontiers in Neuroscience, 2017
The early diagnosis of Parkinson's disease (PD) and the accurate evaluation of disease severity are crucial for intervention and treatment in PD patients.
Chunmei Li   +11 more
doaj   +1 more source

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]

open access: yes, 2017
Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S.   +3 more
core   +3 more sources

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