Emergence of nonmotor symptoms as the focus of research and treatment of Parkinson's disease: Introduction to the special section on nonmotor dysfunctions in Parkinson's disease [PDF]
, 2013 Parkinson's disease (PD) is traditionally characterized by the cardinal motor symptoms of tremor, rigidity, slowness of movement, and impairments of posture, gait, and balance.
Cronin-Golomb, Alice
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Direct detection of alpha synuclein oligomers in vivo [PDF]
, 2014 Background: Rat models of Parkinson’s disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches.
Dimant, Hemi +9 more
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Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb [PDF]
, 2017 Background Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs.
Caretta, Antonio, Mucignat, Carla
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Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation
Neurobiology of Disease, 2015 Although gliosis is a normal response to brain injury, reports on the extent of astrogliosis in the degenerating substantia nigra in Parkinson’s disease (PD) are conflicting.
Junchao Tong +8 more
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Discovery of noncanonical translation initiation sites through mass spectrometric analysis of protein N termini [PDF]
, 2017 Translation initiation generally occurs at AUG codons in eukaryotes, although it has been shown that non-AUG or non-canonical translation initiation can also occur.
Barbhuiya, Mustafa +10 more
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Microstructural changes within the basal ganglia differ between Parkinson disease subtypes
Frontiers in Neuroanatomy, 2016 Diffusion tensor imaging (DTI) of the substantia nigra has shown promise in detecting and quantifying neurodegeneration in Parkinson disease (PD). It remains unknown, however, whether differences in microstructural changes within the basal ganglia ...
Lidia M Nagae +6 more
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A prospective longitudinal study of perceived infant outcomes at 18-24 months: Neural and psychological correlates of parental thoughts and actions assessed during the first month postpartum [PDF]
, 2015 The first postpartum months constitute a critical period for parents to establish an emotional bond with their infants. Neural responses to infant-related stimuli have been associated with parental sensitivity.
Cole, Pamela M. +6 more
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Neurobiology of Disease, 1997 Dopaminergic neurons of the substantia nigra pars compacta were examined in the rat brain following striatal infarction subsequent to transient focal cerebral ischemia.
Marc A. Soriano +4 more
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The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis. [PDF]
PLoS ONE, 2010 BACKGROUND: The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences of injections of 3,4-dihydroxyphenylacetaldehyde (DOPAL), a toxic metabolite of dopamine, into the substantia nigra of rats on motor behavior ...
W Michael Panneton +4 more
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Quantitative profiling of the human substantia nigra proteome from laser-capture microdissected FFPE tissue [PDF]
, 2020 Laser-capture microdissection (LCM) allows the visualization and isolation of morphologically distinct subpopulations of cells from heterogeneous tissue specimens.
Griesser, Eva +5 more
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