Discovery of noncanonical translation initiation sites through mass spectrometric analysis of protein N termini [PDF]
, 2017 Translation initiation generally occurs at AUG codons in eukaryotes, although it has been shown that non-AUG or non-canonical translation initiation can also occur.
Barbhuiya, Mustafa +10 more
core +1 more source
Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation
Neurobiology of Disease, 2015 Although gliosis is a normal response to brain injury, reports on the extent of astrogliosis in the degenerating substantia nigra in Parkinson’s disease (PD) are conflicting.
Junchao Tong +8 more
doaj +1 more source
Environmental Exposures and Parkinson's Disease. [PDF]
, 2016 Parkinson's disease (PD) affects millions around the world. The Braak hypothesis proposes that in PD a pathologic agent may penetrate the nervous system via the olfactory bulb, gut, or both and spreads throughout the nervous system. The agent is unknown,
Litvan, Irene, Nandipati, Sirisha
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Microstructural changes within the basal ganglia differ between Parkinson disease subtypes
Frontiers in Neuroanatomy, 2016 Diffusion tensor imaging (DTI) of the substantia nigra has shown promise in detecting and quantifying neurodegeneration in Parkinson disease (PD). It remains unknown, however, whether differences in microstructural changes within the basal ganglia ...
Lidia M Nagae +6 more
doaj +1 more source
Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb [PDF]
, 2017 Background Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs.
Caretta, Antonio, Mucignat, Carla
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Neurobiology of Disease, 1997 Dopaminergic neurons of the substantia nigra pars compacta were examined in the rat brain following striatal infarction subsequent to transient focal cerebral ischemia.
Marc A. Soriano +4 more
doaj +1 more source
A prospective longitudinal study of perceived infant outcomes at 18-24 months: Neural and psychological correlates of parental thoughts and actions assessed during the first month postpartum [PDF]
, 2015 The first postpartum months constitute a critical period for parents to establish an emotional bond with their infants. Neural responses to infant-related stimuli have been associated with parental sensitivity.
Cole, Pamela M. +6 more
core +2 more sources
The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis. [PDF]
PLoS ONE, 2010 BACKGROUND: The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences of injections of 3,4-dihydroxyphenylacetaldehyde (DOPAL), a toxic metabolite of dopamine, into the substantia nigra of rats on motor behavior ...
W Michael Panneton +4 more
doaj +1 more source
Ontogeny of synaptophysin and synaptoporin in the central nervous system [PDF]
, 1993 The expression of the synaptic vesicle antigens synaptophysin (SY) and synaptoporin (SO) was studied in the rat striatum, which contains a nearly homogeneous population of GABAergic neurons. In situ hybridization revealed high levels of SY transcripts in
B. Marquèze-Pouey +36 more
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Quantitative profiling of the human substantia nigra proteome from laser-capture microdissected FFPE tissue [PDF]
, 2020 Laser-capture microdissection (LCM) allows the visualization and isolation of morphologically distinct subpopulations of cells from heterogeneous tissue specimens.
Griesser, Eva +5 more
core +3 more sources