Results 21 to 30 of about 123,595 (337)

In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson's disease using neuromelanin-sensitive MRI: Replication in two cohorts.

PLoS ONE, 2023
Patients with Parkinson's disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson's disease simultaneously
Kristy S Hwang, Jason Langley, Richa Tripathi, Xiaoping P Hu, Daniel E Huddleston   +4 more
doaj   +3 more sources

Measurement of the adult human midbrain with transcranial ultrasound.

PLoS ONE, 2021
BackgroundTranscranial sonography is increasingly used to aid clinical diagnoses of movement disorders, for example, to identify an enlarged area of substantia nigra echogenicity in patients with Parkinson's disease.ObjectiveThe current study ...
Karl Aoun, Kay L Double, Verity Pearson-Dennett, Rezzak Yilmaz, Daniela Berg, Gabrielle Todd   +5 more
doaj   +1 more source

THE SUBSTANTIA NIGRA SOEMERINGI [PDF]

The Journal OF Nervous and Mental Disease, 1909
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Bauer, Julius, Karpas, M. J.
openaire   +2 more sources

Crystals in the Substantia Nigra [PDF]

ACS Chemical Neuroscience, 2019
Crystals of TiO2 and CaO were detected in electron-beam exposed extracts of four substantia nigra specimens of Parkinson's disease donors. A likely precursor of the CaO crystals is inflammatory calcium oxalate dihydrate, decomposing according to CaC2O4·2H2O → CaO + CO↑ + CO2↑ + 2H2O↑.
Adam Heller, Sheryl S. Coffman
openaire   +3 more sources

Spatiotemporal changes in substantia nigra neuromelanin content in Parkinson's disease.

Brain : a journal of neurology, 2020
This study aimed to investigate the spatiotemporal changes in neuromelanin-sensitive MRI signal in the substantia nigra and their relation to clinical scores of disease severity in patients with early or progressing Parkinson's disease and patients with ...
E. Biondetti, R. Gaurav, L. Yahia-Cherif, G. Mangone, N. Pyatigorskaya, R. Valabrègue, C. Ewenczyk, M. Hutchison, C. François, I. Arnulf, J. Corvol, M. Vidailhet, S. Lehéricy   +12 more
semanticscholar   +1 more source

Neuromelanin Imaging and Dopaminergic Loss in Parkinson’s Disease

Frontiers in Aging Neuroscience, 2016
Parkinson’s disease (PD) is a progressive neurodegenerative disorder in which the major pathologic substrate is a loss of dopaminergic neurons from the substantia nigra.
Ioannis Ugo Isaias, Ioannis Ugo Isaias, Paula Trujillo, Paula Trujillo, Paul Summers, Giorgio Marotta, Luca Mainardi, Gianni Pezzoli, Luigi Zecca, Antonella Costa   +9 more
doaj   +1 more source

Combined Application of Quantitative Susceptibility Mapping and Diffusion Kurtosis Imaging Techniques to Investigate the Effect of Iron Deposition on Microstructural Changes in the Brain in Parkinson’s Disease

Frontiers in Aging Neuroscience, 2022
ObjectivesBrain iron deposition and microstructural changes in brain tissue are associated with Parkinson’s disease (PD). However, the correlation between these factors in Parkinson’s disease has been little studied.
Lin Yang, Lin Yang, Yan Cheng, Yongyan Sun, Yinghua Xuan, Jianping Niu, Jitian Guan, Yunjie Rong, Yanlong Jia, Zerui Zhuang, Gen Yan, Renhua Wu, Renhua Wu   +12 more
doaj   +1 more source

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

Aging Cell, 2019
Parkinson's disease prevalence is rapidly increasing in an aging global population. With this increase comes exponentially rising social and economic costs, emphasizing the immediate need for effective disease‐modifying treatments.
B. G. Trist, D. Hare, K. Double
semanticscholar   +1 more source

A robust method for the detection of small changes in relaxation parameters and free water content in the vicinity of the substantia nigra in Parkinson's disease patients.

PLoS ONE, 2021
Alterations in the substantia nigra are strongly associated with Parkinson's disease. However, due to low contrast and partial volume effects present in typical MRI images, the substantia nigra is not of sufficient size to obtain a reliable segmentation ...
Krzysztof Dzieciol, Elene Iordanishvili, Zaheer Abbas, Adjmal Nahimi, Michael Winterdahl, N Jon Shah   +5 more
doaj   +1 more source

9.4 T MR microscopy of the substantia nigra with pathological validation in controls and disease

NeuroImage: Clinical, 2017
Background: The anatomy of the substantia nigra on conventional MRI is controversial. Even using histological techniques it is difficult to delineate with certainty from surrounding structures.
LA Massey, MA Miranda, O Al-Helli, HG Parkes, JS Thornton, P-W So, MJ White, L Mancini, C Strand, J Holton, AJ Lees, T Revesz, TA Yousry   +12 more
doaj   +1 more source