Results 291 to 300 of about 132,532 (337)
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Innervation of the substantia nigra
Cell and Tissue Research, 2004This review describes inputs to neurons in the substantia nigra and contrasts them with the action of agonists for the putative receptors through which they act. Special emphasis is placed on gamma-aminobutyric acid (GABA) afferents. Dopamine released from the somato-dendritic compartment of dopamine neurons and endocannabinoids released from dopamine ...
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The substantia nigra and stereotyped behaviour
European Journal of Pharmacology, 1972Abstract The acute and chronic effects of bilateral lesions of the substantia nigra upon amphetamine- and apomorphine-induced stereotyped behaviour and its modification by haloperidol and arecoline were studied in the rat. A mild spontaneous stereotyped behaviour was observed during the acute stage following the induction of nigral lesions. In order
B, Costall, R J, Naylor, J E, Olley
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Mitochondrial DNA polymorphism in substantia nigra
Journal of the Neurological Sciences, 1996Inefficiencies in mitochondrial respiration mainly affecting complex I and IV activities, occur with increasing age and have been suggested as a possible etiological factor in age-related neurodegenerative diseases. It has been suggested that this finding may be explained by an accumulation of mtDNA mutations.
R M, Kapsa +8 more
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Synapses in the rat substantia nigra
Tissue and Cell, 1971The composition and organization of the input to the rat substantia nigra were studied with the electron microscope. Four distinct types of synaptic boutons were described. The first contained small (381 A), clear synaptic vesicles. The second type contained the small, clear vesicles and several large, dense-core vesicles.
R L, Gulley, M, Smithberg
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Neuropathology of the Substantia nigra
European Neurology, 1991Neuronal subpopulations of the substantia nigra pars compacta can be separated into two functionally distinct nigrostriatal projections, the ventral tier which is poorly melanised, and the dorsal tier which is well melanised. In Parkinson's disease, juvenile-onset parkinsonism with dystonia and striatonigral degeneration the ventral tier is more ...
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Ontogeny of Substantia Nigra Dopamine Neurons
2009Understanding the ontogeny of A9 dopamine (DA) neurons is critical not only to determining basic developmental events that facilitate the emergence of the substantia nigra pars compacta (SNc) but also to the extraction and de novo generation of DA neurons as a potential cell therapy for Parkinson's disease.
R, Orme, R A, Fricker-Gates, M A, Gates
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Culture of Substantia Nigra Neurons
Current Protocols in Neuroscience, 1997AbstractPrimary cultures of nigral tissue are widely used as a model system to assay effects of trophic and toxic agents on dopaminergic neurons. Cultured dopaminergic neurons have been successfully transplanted in animals and led to behavioral improvement in animal models of Parkinson's disease.
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Neurotensin depolarizes substantia nigra dopamine neurones
Brain Research, 1985Neurotensin and the C-terminal 8-13 amino acid fragment were found to excite substantia nigra compacta dopamine neurones in vitro in a dose-dependent manner. The N-terminal 1-8 amino acid fragment was not active at the concentrations used. Desensitization was not observed.
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