Results 291 to 300 of about 133,054 (344)
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Neurology, 2021
A 20-year-old man without medical history but with septic shock developed neuroleptic malignant syndrome after being treated with loxapine for delirium. He had been admitted to the intensive care unit 2 weeks earlier for septic shock. An MRI done 27 days after admission for persistent unresponsiveness despite weaning of sedation revealed symmetric and ...
François Lersy, Hamid Merdji
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A 20-year-old man without medical history but with septic shock developed neuroleptic malignant syndrome after being treated with loxapine for delirium. He had been admitted to the intensive care unit 2 weeks earlier for septic shock. An MRI done 27 days after admission for persistent unresponsiveness despite weaning of sedation revealed symmetric and ...
François Lersy, Hamid Merdji
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Substantia Nigra Hyperactivity in Schizophrenia
Biological Psychiatry, 2013Mapping the clinical features of schizophrenia to circuits in the brain is a major goal for schizophrenia researchers. The prefrontal cortex (PFC), the ventral midbrain, and the striatum are among the brain areas of primary interest. The PFC has been linked to cognitive deficits, especially impairment of working memory.
Stephan, Heckers, Christine, Konradi
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Dopamine release in substantia nigra?
Nature, 1976IN addition to the axons which project to the nucleus caudatus1,2, the dopamine (DA)-containing perikarya of the substantia nigra have extensive dendritic processes. These dendrites, observed after Golgi staining3–5 and by electron microscopy3,4, contain relatively large amounts of DA—revealed by histofluorescence6—and vesicle–like structures4.
KORF, J, ZIELEMAN, M, WESTERINK, BHC
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Substantia Nigra and Parkinsonism
Archives of Neurology, 1964The opinion that parkinsonism is caused by damage of the substantia nigra was advanced by Brissaud 1 on the basis of the findings in a case of Charcot's studied by Bechet 2 and Blocq and Marinesco. 3 In a series of 54 autopsies Tretiakoff 4 found the substantia nigra degenerated in 16 categories of neurologic disorder including three cases of ...
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Diagnostic evaluation of the substantia nigra
Neuropathology and Applied Neurobiology, 1996An improved method for the histopathological evaluation of the substantia nigra for diagnostic purposes is proposed. This method takes advantage of the natural architecture of the constituent cell clusters of the substantia nigra by combining standardized sections in the horizontal plane and simple quantification. The use of this standardized technique
D A, McRitchie +2 more
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Innervation of the substantia nigra
Cell and Tissue Research, 2004This review describes inputs to neurons in the substantia nigra and contrasts them with the action of agonists for the putative receptors through which they act. Special emphasis is placed on gamma-aminobutyric acid (GABA) afferents. Dopamine released from the somato-dendritic compartment of dopamine neurons and endocannabinoids released from dopamine ...
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The substantia nigra and stereotyped behaviour
European Journal of Pharmacology, 1972Abstract The acute and chronic effects of bilateral lesions of the substantia nigra upon amphetamine- and apomorphine-induced stereotyped behaviour and its modification by haloperidol and arecoline were studied in the rat. A mild spontaneous stereotyped behaviour was observed during the acute stage following the induction of nigral lesions. In order
B, Costall, R J, Naylor, J E, Olley
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Mitochondrial DNA polymorphism in substantia nigra
Journal of the Neurological Sciences, 1996Inefficiencies in mitochondrial respiration mainly affecting complex I and IV activities, occur with increasing age and have been suggested as a possible etiological factor in age-related neurodegenerative diseases. It has been suggested that this finding may be explained by an accumulation of mtDNA mutations.
R M, Kapsa +8 more
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Synapses in the rat substantia nigra
Tissue and Cell, 1971The composition and organization of the input to the rat substantia nigra were studied with the electron microscope. Four distinct types of synaptic boutons were described. The first contained small (381 A), clear synaptic vesicles. The second type contained the small, clear vesicles and several large, dense-core vesicles.
R L, Gulley, M, Smithberg
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