Results 291 to 300 of about 123,845 (338)
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The substantia nigra and stereotyped behaviour
European Journal of Pharmacology, 1972Abstract The acute and chronic effects of bilateral lesions of the substantia nigra upon amphetamine- and apomorphine-induced stereotyped behaviour and its modification by haloperidol and arecoline were studied in the rat. A mild spontaneous stereotyped behaviour was observed during the acute stage following the induction of nigral lesions. In order
Brenda Costall +2 more
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Substantia Nigra and Parkinsonism
Archives of Neurology, 1964The opinion that parkinsonism is caused by damage of the substantia nigra was advanced by Brissaud 1 on the basis of the findings in a case of Charcot's studied by Bechet 2 and Blocq and Marinesco. 3 In a series of 54 autopsies Tretiakoff 4 found the substantia nigra degenerated in 16 categories of neurologic disorder including three cases of ...
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Neuropathology of the Substantia nigra
European Neurology, 1991Neuronal subpopulations of the substantia nigra pars compacta can be separated into two functionally distinct nigrostriatal projections, the ventral tier which is poorly melanised, and the dorsal tier which is well melanised. In Parkinson's disease, juvenile-onset parkinsonism with dystonia and striatonigral degeneration the ventral tier is more ...
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The role of GABA in the substantia nigra
Nature, 1978STRIATONIGRAL GABAergic fibres are widely believed to exert a tonic inhibitory influence on the dopamine (DA)-containing cells of the substantia nigra (SN), and contraversive and ipsiversive circling behaviour can be explained in terms of a greater or lesser activity of the dopaminergic neurones, respectively1,2. However, the blockade of γ-aminobutyric
T. A. James, M. S. Starr
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Evidence for autapses in the substantia nigra
Brain Research, 1980Intracellular recording and intracellular HRP staining were employed to trace the recurrent terminal plexus of cat substantia nigra pars reticulata neurons. Autaptic neurons were labeled. The axon of an autaptic neuron was found to emit a recurrent collateral which distributed 'en passage' and terminal boutons contacting dendrites of the parent cell ...
Athanasios B. Karabelas +1 more
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Dendritic release of dopamine in the substantia nigra [PDF]
Nature, 1981 Dopamine can be released in the substantia nigra for the dendrites of nigrostriatal dopaminergic neurones, to be involved there in the self-regulation of the dopaminergic cells, to control the release of neurotransmitters from nigral afferent fibres and to influence the activity of nigral non-dopaminergic cells.
André Chéramy +2 more
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Synapses in the rat substantia nigra
Tissue and Cell, 1971The composition and organization of the input to the rat substantia nigra were studied with the electron microscope. Four distinct types of synaptic boutons were described. The first contained small (381 A), clear synaptic vesicles. The second type contained the small, clear vesicles and several large, dense-core vesicles.
Robert L. Gulley, Morris Smithberg
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The substantia nigra of the rat: A golgi study
Journal of Comparative Neurology, 1977AbstractThree variants of the Golgi method were employed to examine the cell types, their dendritic fields and organization and azonal trajectories within the substantia nigra of albino and hooded rats. In both sagittal and coronal sections, large, medium and small neurons were classified on the basis of soma size, extent of dendritic fields and ...
Philip M. Groves +2 more
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GABAergic synaptic interactions in the substantia nigra
Brain Research, 1993The substantia nigra receives a strong GABAergic input from the ipsilateral striatum and globus pallidus. Nigral GABAergic synaptic interactions have been described in the pars compacta (SNC) and pars reticulata (SNR) but not in the pars lateralis (SNL). The SNR and particularly the SNL are the nodal points of the GABAergic nigrotectal pathway.
B. A. Flumerfelt +2 more
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Uptake of Acetylcholinesterase by Neurons in the Substantia Nigra
European Journal of Neuroscience, 1995AbstractIt is known that acetylcholinesterase is secreted by the dopaminergic neurons of the substantia nigra and has a subsequent action independent of cholinergic transmission. Although non‐cholinergic actions of this protein have been demonstrated, the subsequent fate of acetylcholinesterase is unknown.
B. G. M. Dickie +3 more
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