Results 291 to 300 of about 129,849 (338)
Dendritic release of dopamine in the substantia nigra [PDF]
Nature, 1981 Dopamine can be released in the substantia nigra for the dendrites of nigrostriatal dopaminergic neurones, to be involved there in the self-regulation of the dopaminergic cells, to control the release of neurotransmitters from nigral afferent fibres and to influence the activity of nigral non-dopaminergic cells.
André Chéramy +2 more
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Uptake of Acetylcholinesterase by Neurons in the Substantia Nigra
European Journal of Neuroscience, 1995AbstractIt is known that acetylcholinesterase is secreted by the dopaminergic neurons of the substantia nigra and has a subsequent action independent of cholinergic transmission. Although non‐cholinergic actions of this protein have been demonstrated, the subsequent fate of acetylcholinesterase is unknown.
B. G. M. Dickie +3 more
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The substantia nigra of the rat: A golgi study
Journal of Comparative Neurology, 1977AbstractThree variants of the Golgi method were employed to examine the cell types, their dendritic fields and organization and azonal trajectories within the substantia nigra of albino and hooded rats. In both sagittal and coronal sections, large, medium and small neurons were classified on the basis of soma size, extent of dendritic fields and ...
Philip M. Groves +2 more
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GABAergic synaptic interactions in the substantia nigra
Brain Research, 1993The substantia nigra receives a strong GABAergic input from the ipsilateral striatum and globus pallidus. Nigral GABAergic synaptic interactions have been described in the pars compacta (SNC) and pars reticulata (SNR) but not in the pars lateralis (SNL). The SNR and particularly the SNL are the nodal points of the GABAergic nigrotectal pathway.
B. A. Flumerfelt +2 more
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Death in the substantia nigra: a motor tragedy
Expert Review of Neurotherapeutics, 2007It is well known that the death of dopaminergic neurons of the substantia nigra pars compacta (SNc) is the pathological hallmark of Parkinson's disease (PD), the second most common and disabling condition in the expanding elderly population. Nevertheless, the intracellular cascade of events leading to dopamine cell death is still unknown and ...
ESPOSITO E +2 more
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Osmosensitive response of glutamate in the substantia nigra
Experimental Neurology, 2009Previous studies have suggested the increase of extracellular glutamate (GLU) in the substantia nigra (SN) as a cause of dopamine-cell degeneration (excitotoxicity) in Parkinson's disease (PD). However, the mechanisms involved in this increase remain unknown. The present work studied osmoregulation as a cause of GLU release in the SN. Microdialysis was
Morales Pérez, Ingrid +3 more
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Hyperechogenicity of the Substantia Nigra in Parkinson's Disease
Journal of Neuroimaging, 2007ABSTRACTSubstantia nigra (SN) was assessed by transcranial sonography (TCS) in 47 Parkinson's disease (PD) patients and in 39 healthy volunteers. A semiquantitative echogenicity scale was created with arbitrary values ranging from 1 to 5, zones with grade ≥3 and larger than 0.19 cm2 were recorded as hyperechogenic SN.
David Školoudík +3 more
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Ultrastructure of developing substantia nigra in humans
International Journal of Developmental Neuroscience, 1996AbstractElectron microscopy of the maturing neurons and developing and maturing synapses in the substantia nigra of 14 human embryos/foetuses of 8–24 weeks of gestation are reported. At 8 weeks, cells were immature with very little cytoplasm and cellular organelles. Contact sites of processes appeared more electron dense than the other areas.
K. Sailaja, Gomathy Gopinath
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Culture of Substantia Nigra Neurons
Current Protocols in Neuroscience, 1997AbstractPrimary cultures of nigral tissue are widely used as a model system to assay effects of trophic and toxic agents on dopaminergic neurons. Cultured dopaminergic neurons have been successfully transplanted in animals and led to behavioral improvement in animal models of Parkinson's disease.
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Neuromelanin and RNA in Cells of Substantia Nigra
Journal of Neuropathology & Experimental Neurology, 1977We have found that with accumulation of neuromelanin granules within cell bodies of neurones of the human substantia nigra there is a reduction in cytoplasmic RNA and a decrease in nucleolar volume. These observations imply a gradual decrease in the functional capacity of the cell such that eventually, the cell is unable to produce sufficient protein ...
D. M. A. Mann, P. O. Yates, C. M. Barton
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