Results 31 to 40 of about 123,595 (337)

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Mitochondrial dysfunction within the synapses of substantia nigra neurons in Parkinson’s disease

npj Parkinson's Disease, 2018
Mitochondrial dysfunction within the cell bodies of substantia nigra neurons is prominent in both ageing and Parkinson’s disease. The loss of dopaminergic substantia nigra neurons in Parkinson’s disease is associated with loss of synapses within the ...
A. Reeve, J. Grady, E. Cosgrave, E. Bennison, Chun Chen, Philippa D. Hepplewhite, C. Morris   +6 more
semanticscholar   +1 more source

Comparative Study of MRI Biomarkers in the Substantia Nigra to Discriminate Idiopathic Parkinson Disease

American Journal of Neuroradiology, 2018
BACKGROUND AND PURPOSE: Several new MR imaging techniques have shown promising results in patients with Parkinson disease; however, the comparative diagnostic values of these measures at the individual level remain unclear.
N. Pyatigorskaya, B. Magnin, Marie Mongin, L. Yahia-Cherif, R. Valabrègue, Dario Arnaldi, C. Ewenczyk, Cyril Poupon, M. Vidailhet, S. Lehéricy   +9 more
semanticscholar   +1 more source

Microstructural changes within the basal ganglia differ between Parkinson disease subtypes

Frontiers in Neuroanatomy, 2016
Diffusion tensor imaging (DTI) of the substantia nigra has shown promise in detecting and quantifying neurodegeneration in Parkinson disease (PD). It remains unknown, however, whether differences in microstructural changes within the basal ganglia ...
Lidia M Nagae, Justin M Honce, Jody eTanabe, Erika eShelton, Stefan H Sillau, Brian D Berman, Brian D Berman   +6 more
doaj   +1 more source

The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis. [PDF]

PLoS ONE, 2010
BACKGROUND: The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences of injections of 3,4-dihydroxyphenylacetaldehyde (DOPAL), a toxic metabolite of dopamine, into the substantia nigra of rats on motor behavior ...
W Michael Panneton, V B Kumar, Qi Gan, William J Burke, James E Galvin   +4 more
doaj   +1 more source

The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra

PLoS ONE, 2018
Presynaptic cannabinoid-1 receptors (CB1-R) bind endogenous and exogenous cannabinoids to modulate neurotransmitter release. CB1-Rs are expressed throughout the basal ganglia, including striatum and substantia nigra, where they play a role in learning ...
Margaret I Davis, J. Crittenden, A. Feng, D. Kupferschmidt, Alipi V Naydenov, N. Stella, A. Graybiel, D. Lovinger   +7 more
semanticscholar   +1 more source

Substantia Nigra Free Water Increases Longitudinally in Parkinson Disease

American Journal of Neuroradiology, 2018
BACKGROUND AND PURPOSE: Free water in the posterior substantia nigra obtained from a bi-tensor diffusion MR imaging model has been shown to significantly increase over 1- and 4-year periods in patients with early-stage idiopathic Parkinson disease ...
T. Guttuso, N. Bergsland, J. Hagemeier, D. Lichter, O. Pasternak, R. Zivadinov   +5 more
semanticscholar   +1 more source

Signal alterations of the basal ganglia in the differential diagnosis of Parkinson’s disease: a retrospective case-controlled MRI data bank analysis

BMC Neurology, 2012
Background Based upon the acquainted loss of dopaminergic neurons in the substantia nigra in Parkinson’s disease (PD), we hypothesised changes in magnetic resonance imaging signal intensities of the basal ganglia to be useful as an additional technical ...
Jesse Sarah, Kassubek Jan, Müller Hans-Peter, Ludolph Albert C, Unrath Alexander   +4 more
doaj   +1 more source

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

Nature Communications, 2016
Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD).
Christian Dölle, I. Flønes, Gonzalo S. Nido, H. Miletic, Nelson Osuagwu, S. Kristoffersen, P. Lilleng, J. Larsen, O. Tysnes, K. Haugarvoll, L. Bindoff, C. Tzoulis   +11 more
semanticscholar   +1 more source

Chemical Exchange Saturation Transfer MRI Signal Loss of the Substantia Nigra as an Imaging Biomarker to Evaluate the Diagnosis and Severity of Parkinson's Disease

Frontiers in Neuroscience, 2017
The early diagnosis of Parkinson's disease (PD) and the accurate evaluation of disease severity are crucial for intervention and treatment in PD patients.
Chunmei Li, Min Chen, Xuna Zhao, Rui Wang, Haibo Chen, Wen Su, Shuhua Li, Baohui Lou, Guodong Song, Shuai Zhang, Jintao Zhang, Jinyuan Zhou   +11 more
doaj   +1 more source