Results 31 to 40 of about 133,054 (344)

Quantitative profiling of the human substantia nigra proteome from laser-capture microdissected FFPE tissue [PDF]

, 2020
Laser-capture microdissection (LCM) allows the visualization and isolation of morphologically distinct subpopulations of cells from heterogeneous tissue specimens.
Griesser, Eva, Lamond, Angus I., Lenter, Martin, Stierstorfer, Birgit, Ten Have, Sara, Wyatt, Hannah   +5 more
core   +3 more sources

Distribution and Modulation of Histamine H3 Receptors in Basal Ganglia and Frontal Cortex of Healthy Controls and Patients with Parkinson's Disease

Neurobiology of Disease, 2001
Parkinson's disease (PD) is a brain degenerative disorder with unknown etiology, and specific degeneration of mesencephalic dopaminergic cells is a morphological manifestation of the disease. The central histaminergic system appears to be activated in PD,
Oleg V. Anichtchik, Nina Peitsaro, Juha O. Rinne, Hannu Kalimo, Pertti Panula   +4 more
doaj   +1 more source

Crystals in the Substantia Nigra [PDF]

ACS Chemical Neuroscience, 2019
Crystals of TiO2 and CaO were detected in electron-beam exposed extracts of four substantia nigra specimens of Parkinson's disease donors. A likely precursor of the CaO crystals is inflammatory calcium oxalate dihydrate, decomposing according to CaC2O4·2H2O → CaO + CO↑ + CO2↑ + 2H2O↑.
Adam Heller, Sheryl S. Coffman
openaire   +2 more sources

Eyes as Gateways for Environmental Light to the Substantia Nigra: Relevance in Parkinson’s Disease

The Scientific World Journal, 2014
Recent data indicates that prolonged bright light exposure of rats induces production of neuromelanin and reduction of tyrosine hydroxylase positive neurons in the substantia nigra. This effect was the result of direct light reaching the substantia nigra
Stefania Romeo, Daniela Di Camillo, Alessandra Splendiani, Marta Capannolo, Cristina Rocchi, Gabriella Aloisi, Irene Fasciani, Giovanni U. Corsini, Eugenio Scarnati, Luca Lozzi, Roberto Maggio   +10 more
doaj   +1 more source

Signal alterations of the basal ganglia in the differential diagnosis of Parkinson’s disease: a retrospective case-controlled MRI data bank analysis

BMC Neurology, 2012
Background Based upon the acquainted loss of dopaminergic neurons in the substantia nigra in Parkinson’s disease (PD), we hypothesised changes in magnetic resonance imaging signal intensities of the basal ganglia to be useful as an additional technical ...
Jesse Sarah, Kassubek Jan, Müller Hans-Peter, Ludolph Albert C, Unrath Alexander   +4 more
doaj   +1 more source

A Direct Cortico-Nigral Pathway as Revealed by Constrained Spherical Deconvolution Tractography in Humans

Frontiers in Human Neuroscience, 2016
Substantia nigra is an important neuronal structure, located in the ventral midbrain, that exerts a regulatory function within the basal ganglia circuitry through the nigro-striatal pathway.
Alberto Cacciola, Demetrio Milardi, Demetrio Milardi, Giuseppe Pio Anastasi, Gianpaolo Antonio Basile, Pietro Ciolli, Mariangela Irrera, Giuseppina Cutroneo, Daniele Bruschetta, Giuseppina Rizzo, Stefania Mondello, Placido Bramanti, Angelo Quartarone, Angelo Quartarone   +13 more
doaj   +1 more source

Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]

, 2016
Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano, Bisaglia, Marco, Bubacco, Luigi, Filograna, Roberta   +3 more
core   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Late-onset Parkinsonism in NFκB/c-Rel-deficient mice. [PDF]

, 2012
Activation of the nuclear factor \u3baB/c-Rel can increase neuronal resilience to pathological noxae by regulating the expression of pro-survival manganese superoxide dismutase (MnSOD, now known as SOD2) and Bcl-xL genes.
Alghisi M, Baiguera C, Bellucci A, Benarese M, Bertini G, De Luca MA, Fabene PF, Frau L, Ingrassia R, Liou HC, Morelli M, Pellitteri M, Pinna A, Pizzi M, Porrini V, Sigala S, Spano PF, Spillantini MG   +17 more
core   +3 more sources

Bright light exposure reduces TH-positive dopamine neurons: implications of light pollution in Parkinson's disease epidemiology. [PDF]

, 2013
This study explores the effect of continuous exposure to bright light on neuromelanin formation and dopamine neuron survival in the substantia nigra.
Allison W. Willis,, Brad A. Racette,, Cristina Rocchi, 3, Daniela Di Camillo,, Francesca Vaglini,, Gabriella Aloisi,, Giovanni U. Corsini, 4, Luca Lozzi, 4, Marta Capannolo,, Matteo Caleo, 1, MISSALE, Mariacristina, Rita Maccarone, 2, Roberto Maggio, 2, Stefania Romeo, Cristina Viaggi   +13 more
core   +1 more source