Results 41 to 50 of about 71,981 (295)
Depth‐Customizable 3D Electrode Array for Recording Functional Connectivity in the Brain
Advanced Electronic Materials, EarlyView.In this study, a depth‐adjustable, flexible 3D multi‐shank electrode array that produces precise neural recordings at various brain depths is developed. Integrating 2D flexible electrode arrays with a modular supporting board allowed the insertion depth to be easily adjusted without re‐fabrication.
Minseok Kim +5 more
wiley +1 more source
New MRI diagnostic methods in Parkinson's disease: evaluating nigral degeneration
Анналы клинической и экспериментальной неврологии, 2019 Research Center of Neurology, Moscow, Russia Parkinson's disease (PD) is a progressive neurodegenerative disorder with a characteristic pathological hallmark of loss of the dopaminergic neurons in the compact part of the substantia nigra in the ...
Sergey N. Illarioshkin +3 more
doaj +1 more source
Aggregate, EarlyView.A supramolecular fluorescent probe, TPE‐4B/4Q[7], was designed to target lysosomes. The restriction of intramolecular rotation effect mediated by Q[7] enhances the fluorescence of TPE‐4B/4Q[7], enabling selective detection of Fe3+ with a detection limit of 1.23 × 10⁻⁶ M.
Shiqin Zhou +11 more
wiley +1 more source
Cell Transplantation, 1999 Current clinical protocols for fetal cell transplantation for Parkinson's disease (PD) have focused on restoring dopamine in the striatum. However, there are now a number of human transplant recipients who have had robust innervation of the striatum by ...
Philip A. Starr M.D.,Ph.D. +3 more
doaj +1 more source
Diffusion Kurtosis Imaging for Detection of Early Brain Changes in Parkinson's Disease
Frontiers in Neurology, 2019 We aimed to evaluate microscale changes in the bilateral red nucleus and substantia nigra of patients with Parkinson's disease (PD) using diffusion kurtosis imaging (DKI).
Jitian Guan +17 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.At steady state, DRG ensures low‐level expression of TH+ neurons under the protection of AKT. However, the DRG level of PD mouse model under MPTP toxicity increased significantly, and the expression of IL‐6 and CASP3 increased. This process was accompanied by the occurrence of m6A demethylation, with a significant increase in FTO as the main ...
Yatan Li +6 more
wiley +1 more source
Beitrag zur vergleichenden Anatomie der Substantia nigra, des Corpus Luysii und der Zona incerta. (Fortsetzung.) [PDF]
, 1910 Torata Sano
openalex +2 more sources
Animal Models and Experimental Medicine, EarlyView.In this study, we established a mouse model in which CAG repeats do not undergo microsatellite instability (MSI) across generations. A humanized ATXN2 cDNA with four CAA interruptions within 73 CAG expansions was inserted into the Rosa26 locus of C57BL/6J mice. At the same time, a 23 CAG control mouse model was also generated.
Yao Zhang +9 more
wiley +1 more source
Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation
Neurobiology of Disease, 2015 Although gliosis is a normal response to brain injury, reports on the extent of astrogliosis in the degenerating substantia nigra in Parkinson’s disease (PD) are conflicting.
Junchao Tong +8 more
doaj
Research advances in dysphagia animal models
Animal Models and Experimental Medicine, EarlyView.This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai +5 more
wiley +1 more source