Results 1 to 10 of about 3,489,473 (275)

Gardenia jasminoides J. Ellis extract GJ-4 attenuates hyperlipidemic vascular dementia in rats via regulating PPAR-γ-mediated microglial polarization

Food & Nutrition Research, 2022
Background: GJ-4 is extracted from Gardenia jasminoides J. Ellis (Fructus Gardenia) with crocin composition and has been demonstrated to improve memory deficits in several dementia models in our previous studies.
Hui Liu, Caixia Zang, Junmei Shang, Zihong Zhang, Lu Wang, Hanyu Yang, Chanjuan Sheng, Fangyu Yuan, Cheng Ju, Fangyuan Li, Yang Yu, Xinsheng Yao, Xiuqi Bao, Dan Zhang   +13 more
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Caspase substrates [PDF]

Cell Death & Differentiation, 2006
The relatively common occurrence of sequences within proteins that match the consensus substrate specificity of caspases in intracellular proteins suggests a multitude of substrates in vivo - somewhere in the order of several hundred in humans alone. Indeed, the list of proteins that are reported to be cleaved by caspases in vitro proliferates rapidly.
J C, Timmer, G S, Salvesen
openaire   +2 more sources

Fecal microbiota transplantation protects rotenone-induced Parkinson’s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis

Microbiome, 2021
Background Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, displaying not only well-known motor deficits but also gastrointestinal dysfunctions.
Zhe Zhao, Jingwen Ning, Xiu-qi Bao, Meiyu Shang, Jingwei Ma, Gen Li, Dan Zhang   +6 more
doaj   +1 more source

Angular Color Uniformity Enhancement for Color-Mixed LEDs by Introducing a Diffusing Coating Layer

IEEE Photonics Journal, 2020
In this study, a simple and low-cost method is proposed to enhance angular color uniformity (ACU) of color-mixed light-emitting diodes (cm-LEDs) by introducing a diffuse coating layer.
Xin Zhu, Guangxu Wang, Xin Luo, Jianli Zhang, Junlin Liu, Xing Guo   +5 more
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Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota–gut–brain axis

Acta Pharmaceutica Sinica B, 2021
Parkinson's disease (PD) is the second most common neurodegenerative disease, but none of the current treatments for PD can halt the progress of the disease due to the limited understanding of the pathogenesis.
Zhe Zhao, Fangyuan Li, Jingwen Ning, Ran Peng, Junmei Shang, Hui Liu, Meiyu Shang, Xiu-Qi Bao, Dan Zhang   +8 more
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Inhibition of CXCR2 enhances CNS remyelination via modulating PDE10A/cAMP signaling pathway

Neurobiology of Disease, 2023
CXC chemokine receptor 2 (CXCR2) plays an important role in demyelinating diseases, but the detailed mechanisms were not yet clarified. In the present study, we mainly investigated the critical function and the potential molecular mechanisms of CXCR2 on ...
Cheng Ju, Fangyu Yuan, Lu Wang, Caixia Zang, Jingwen Ning, Meiyu Shang, Jingwei Ma, Gen Li, Yang Yang, Qiuzhu Chen, Yueqi Jiang, Fangfang Li, Xiuqi Bao, Dan Zhang   +13 more
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Distinct Identity of GLP-1R, GLP-2R, and GIPR Expressing Cells and Signaling Circuits Within the Gastrointestinal Tract

Frontiers in Cell and Developmental Biology, 2021
Enteroendocrine cells directly integrate signals of nutrient content within the gut lumen with distant hormonal responses and nutrient disposal via the production and secretion of peptides, including glucose-dependent insulinotropic polypeptide (GIP ...
Nadya M. Morrow, Nadya M. Morrow, Antonio A. Hanson, Antonio A. Hanson, Erin E. Mulvihill, Erin E. Mulvihill, Erin E. Mulvihill, Erin E. Mulvihill   +7 more
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Islet Health, Hormone Secretion, and Insulin Responsivity with Low-Carbohydrate Feeding in Diabetes

Metabolites, 2020
Exploring new avenues to control daily fluctuations in glycemia has been a central theme for diabetes research since the Diabetes Control and Complications Trial (DCCT).
Cassandra A. A. Locatelli, Erin E. Mulvihill   +1 more
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31.38 Gb/s GaN-based LED array visible light communication system enhanced with V-pit and sidewall quantum well structure

Opto-Electronic Science, 2023
Although the 5G wireless network has made significant advances, it is not enough to accommodate the rapidly rising requirement for broader bandwidth in post-5G and 6G eras.
Zengyi Xu, Wenqing Niu, Yu Liu, Xianhao Lin, Jifan Cai, Jianyang Shi, Xiaolan Wang, Guangxu Wang, Jianli Zhang, Fengyi Jiang, Zhixue He, Shaohua Yu, Chao Shen, Junwen Zhang, Nan Chi   +14 more
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CXCR2 antagonism promotes oligodendrocyte precursor cell differentiation and enhances remyelination in a mouse model of multiple sclerosis

Neurobiology of Disease, 2020
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease characterized by the autoimmune attack of oligodendrocytes, leading to demyelination and progressive functional deficits.
Lu Wang, Hanyu Yang, Caixia Zang, Yi Dong, Junmei Shang, Jiajing Chen, Yue Wang, Hui Liu, Zihong Zhang, Heng Xu, Xiuqi Bao, Dan Zhang   +11 more
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