Results 41 to 50 of about 2,480,115 (256)
Contains three excel sheet tabs: "indvar_substrate_select", "indvar_riffle_character", "substrate_profile". First, "indvar_substrate_select" corresponds to the evaluation of individual sampler bias in substrate selection at a point along a transect ...
Jane S. Fencl (822598) +7 more
core +1 more source
Conserved Omp85 lid-lock structure and substrate recognition in FhaC [PDF]
Omp85 proteins mediate translocation of polypeptide substrates across and into cellular membranes. They share a common architecture comprising substrate-interacting POTRA domains, a C-terminal 16-stranded β-barrel pore and two signature motifs located on
Delattre, Anne-Sophie +7 more
core +1 more source
Substrate-mediated reconfiguration of lipid multilayered films.
Schematics and simulations (discussed further in Fig 5) of the multiscale structure of multilayered lipid films on a deformable substrate before (A) and after (B) compression.
Narayana R. Aluru (1624165) +7 more
core +1 more source
Although submarine canyons are internationally recognized as sensitive ecosystems and reported to be biological hotspots, regional studies are required to validate this consensus.
Zoleka Filander +7 more
doaj +1 more source
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Substrate-Supported Lipid Nanotube Arrays
This Communication describes the self-assembly of phospholipids into lipid nanotubes inside nanoporous anodic aluminum oxide substrate. Orientations of the lipid molecules in such lipid nanoscale structures were verified by high-resolution spin labeling ...
Alex I. Smirnov (1665136) +1 more
core +1 more source
Eleven series of water kefir fermentation processes differing in the presence of oxygen and the type and concentration of inoculum and substrate, were followed as a function of time to quantify the impact of these parameters on the kinetics of this ...
David Laureys +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Substrate-Based Allosteric Regulation of a Homodimeric Enzyme
Many enzymes operate through half-of-the sites reactivity wherein a single protomer is catalytically engaged at one time. In the case of the homodimeric enzyme, fluoroacetate dehalogenase, substrate binding triggers closing of a regulatory cap domain in ...
Adnan Sljoka +19 more
core +1 more source

