Results 51 to 60 of about 2,207,070 (314)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Visual and non-visual effects of the phosphor-free white LED lamps rich in the 535–589-nm yellow-green light

Light: Science & Applications
Despite an increasing number of researches focused on the photo-biological effects of lighting on visual and non-visual health, insights into the phosphor-free white LED lamps with different spectral power distributions remain unclear.
Shanshan Zeng, Ya Guo, Wentao Hao, Xin Luo, Xing Guo, Jianli Zhang, Jianqi Cai, Guangxu Wang   +7 more
doaj   +1 more source

The circle of reentry: Characteristics of trigger-substrate interaction leading to sudden cardiac arrest

Frontiers in Cardiovascular Medicine, 2023
Sudden cardiac death is often caused by ventricular arrhythmias driven by reentry. Comprehensive characterization of the potential triggers and substrate in survivors of sudden cardiac arrest has provided insights into the trigger-substrate interaction ...
Matthijs J. M. Cluitmans, Matthijs J. M. Cluitmans, Jason Bayer, Laura R. Bear, Rachel M. A. ter Bekke, Jordi Heijman, Ruben Coronel, Paul G. A. Volders   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Microbial metabolite 3-indolepropionic acid alleviated PD pathologies by decreasing enteric glia cell gliosis via suppressing IL-13Rα1 related signaling pathways

Acta Pharmaceutica Sinica B
Although enteric glial cell (EGC) abnormal activation is reported to be involved in the pathogenesis of Parkinson's disease (PD), and inhibition of EGC gliosis alleviated gut and dopaminergic neuronal dysfunction was verified in our previous study, the ...
Meiyu Shang, Jingwen Ning, Caixia Zang, Jingwei Ma, Yang Yang, Zhirong Wan, Jing Zhao, Yueqi Jiang, Qiuzhu Chen, Yirong Dong, Jinrong Wang, Fangfang Li, Xiuqi Bao, Dan Zhang   +13 more
doaj   +1 more source

Assessment of Caffeine-degrading Ability on Bacterial Strains Klebsiella sp. Isolated from Feces of Asian Palm Civet (Luwak)

International Journal of Technology, 2023
Asian palm civet (APC) known as Luwak, has an important role in producing the most expensive coffee in the world, Kopi Luwak, which is excreted from its feces.
Toto Iswanto, Maya Shovitri, Ali Altway, Tri Widjaja, Puspita Lisdiyanti, Atha Pahlevi Putra   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Benthic species patterns in and around the Cape Canyon: A large submarine canyon off the western passive margin of South Africa

Frontiers in Marine Science, 2022
Although submarine canyons are internationally recognized as sensitive ecosystems and reported to be biological hotspots, regional studies are required to validate this consensus.
Zoleka Filander, Adam N. H. Smith, Adam N. H. Smith, Hayley C. Cawthra, Hayley C. Cawthra, Tarron Lamont, Tarron Lamont, Tarron Lamont   +7 more
doaj   +1 more source

Substrate-Directed Lewis-Acid Catalysis for Peptide Synthesis [PDF]

, 2019
A Lewis-acid-catalyzed method for the substrate-directed formation of peptide bonds has been developed, and this powerful approach is utilized for the new “remote” activation of carboxyl groups under solvent-free conditions.
Tomohiro Hattori, Wataru Muramatsu, Wataru Muramatsu (1633348), Tomohiro Hattori (2560639), Hisashi Yamamoto (1306170), Hisashi Yamamoto   +5 more
core   +1 more source

Substrate-Directed Enantioselective Aziridination of Alkenyl Alcohols Controlled by a Chiral Cation [PDF]

, 2023
Alkene aziridination is a highly versatile transformation for the construction of chiral nitrogen-containing compounds. Inspired by the success of analogous substrate-directed epoxidations, we report an enantioselective aziridination of alkenyl alcohols,
Alexander Fanourakis (7011182), Arthur R. Lit (14837633), Nicholas J. Hodson (14837630), Robert J. Phipps (2226601)   +3 more
core   +1 more source