Results 51 to 60 of about 2,477,868 (369)

Embryonic stem cells become mechanoresponsive upon exit from ground state of pluripotency [PDF]

Open Biology, 2019
Stem cell fate decisions are driven by a broad array of signals, both chemical and mechanical. Although much progress has been made in our understanding of the impact of chemical signals on cell fate choice, much less is known about the role and ...
C. M. Verstreken, C. Labouesse, C. C. Agley, K. J. Chalut   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Concept and optical design of the cross-disperser module for CRIRES [PDF]

, 2014
This is the peer reviewed version of the following article: Oliva, Ernesto, A. Tozzi, D. Ferruzzi, L. Origlia, A. Hatzes, R. Follert, T. Loewinger et al.
Anglada-Escude, G, Baade, D, Bristow, P, Delabre, B, Dorn, RJ, Ferruzzi, D, Follert, R, Gojak, D, Grunhut, J, Hatzes, A, Heiter, U, Hilker, M, Ives, DJ, Jung, Y, Kaeufl, HU, Kerber, F, Klein, B, Lizon, JL, Lockhart, M, Loewinger, T, Marquart, T, Oliva, E, Origlia, L, Pasquini, L, Paufique, J, Piskunov, N, Pozna, E, Reiners, A, Seemann, U, Smette, A, Smoker, J, Stempels, E, Tozzi, A, Valenti, E   +33 more
core   +2 more sources

Rewiring mesenchymal stem cell lineage specification by switching the biophysical microenvironment

Scientific Reports, 2014
The propensity of stem cells to specify and commit to a particular lineage program is guided by dynamic biophysical and biochemical signals that are temporally regulated.
Junmin Lee, Amr A. Abdeen, K. Kilian
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Regulation of plasma membrane expansion during axon formation [PDF]

, 2018
Here, will review current evidence regarding the signaling pathways and mechanisms underlying membrane addition at sites of active growth during axon formation.Fil: Quiroga, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas.
Bisbal, Mariano, Caceres, Alfredo Oscar, Quiroga, Santiago   +2 more
core   +1 more source

The Substrate Specificity of Fumarase

Journal of Biological Chemistry, 1968
Abstract The substrate specificity of fumarase has been studied by measuring the ability of the enzyme to hydrate or dehydrate derivatives of fumarate and l-malate. Fumarase was observed to hydrate fumarate and its derivatives in the order, fluorofumarate g fumarate g chlorofumarate g bromofumarate g acetylenedicarboxylate g iodofumarate g mesaconate ...
J W, Teipel, G M, Hass, R L, Hill
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Impact of severe cracked germanium (111) substrate on aluminum indium gallium phosphate light-emitting-diode’s electro-optical performance

Open Physics, 2016
Cracked die is a serious failure mode in the Light Emitting Diode (LED) industry – affecting LED quality and long-term reliability performance. In this paper an investigation has been carried out to find the correlation between severe cracked germanium ...
Annaniah Luruthudass, Devarajan Mutharasu   +1 more
doaj   +1 more source

Qubit compatible superconducting interconnects

, 2017
We present a fabrication process for fully superconducting interconnects compatible with superconducting qubit technology. These interconnects allow for the 3D integration of quantum circuits without introducing lossy amorphous dielectrics.
Arya, K., Barends, R., Burkett, B., Chen, Yu, Chen, Zijun, Chiaro, B., Dunsworth, A., Fowler, A., Foxen, B., Gidney, C., Giustina, M., Graff, R., Huang, T., Jeffrey, E., Kelly, J., Klimov, P., Lucero, E., Martinis, John M., Megrant, A., Mutus, J. Y., Neeley, M., Neill, C., Quintana, C., Roushan, P., Sank, D., Vainsencher, A., Wenner, J., White, T. C., Yang, Yan, Yu, Anthony   +29 more
core   +1 more source