Results 61 to 70 of about 33,198 (306)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Substrate specificity of haloalkane dehalogenases [PDF]
Biochemical Journal, 2011 An enzyme's substrate specificity is one of its most important characteristics. The quantitative comparison of broad-specificity enzymes requires the selection of a homogenous set of substrates for experimental testing, determination of substrate-specificity data and analysis using multivariate statistics.
Tana, Koudelakova +6 more
openaire +2 more sources
Exploring cell-substrate interactions in stem cell self-renewal and differentiation [PDF]
, 2013 Tissue engineering aims to replace diseased or damaged tissue, one approach for which is to implant cells and a scaffold developed in vitro. One of the engineering challenges is the design of the cell-material interface.
LaPointe, Vanessa Lydia Simone
core +1 more source
Deterministic Inference Substrate [PDF]
This paper presents a unified deterministic inference substrate grounded in coherence invariants rather than probabilistic approximation. Identity, legality, architectural structure, and recurrence are treated as a single irreducible system.
Bostick, Devin
core +1 more source
Multicomponent Thin Films Deposited by PVD ARC and LARC Technology
Medžiagotyra, 2014 The paper is focused on a comparison of advanced layers deposited by two coating technologies – cathodic arc deposition (ARC) and lateral rotating cathodes (LARC).
Dagmar JAKUBÉCZYOVÁ +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Scientific ReportsThe extracellular matrix (ECM) plays a vital role in stem cell differentiation to endothelial cells in vivo and is also important for the specification of endothelial cells in vitro.
Mikayla L. Hall +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
An RGD-restricted substrate interface is sufficient for the adhesion, growth and cartilage forming capacity of human chondrocytes [PDF]
, 2010 This study aimed at testing whether an RGD-restricted substrate interface is sufficient for adhesion and growth of human articular chondrocytes (HAC), and whether it enhances their post expansion chondrogenic capacity.
M Textor +15 more
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