Results 51 to 60 of about 33,198 (306)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Controlled Demolition: Smurf1 Regulates Neuronal Polarity by Substrate Switching

, 2011
During axon specification, growth promoting proteins localize selectively to the growing axon. In this issue of Neuron, Cheng et al. report how selective protein degradation, controlled by a substrate switch of the ubiquitin ligase Smurf1, specifies Par6
Frank Bradke, Bradke, Frank, Michael Stiess, Stiess, M., Stiess, Michael, Bradke, F.   +5 more
core   +1 more source

Investigation of Micromachined Antenna Substrates Operating at 5 GHz for RF Energy Harvesting Applications

Micromachines, 2019
This paper investigates micromachined antenna performance operating at 5 GHz for radio frequency (RF) energy harvesting applications by comparing different substrate materials and fabrication modes.
Noor Hidayah Mohd Yunus, Jumril Yunas, Alipah Pawi, Zeti Akma Rhazali, Jahariah Sampe   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Specification guidelines for surface preparation of concrete prior to repair [PDF]

, 2017
peer reviewedThe repair of concrete requests specific preparation operations needed for guaranteeing compatibility between substrate and new materials as well as the development of adhesion properties.
Benoît Bissonnette, Courard, Luc, Andrzej Garbacz, Bissonnette, Benoît, Luc Courard, Garbacz, Andrzej   +5 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence [PDF]

, 2011
Intrinsic antiviral resistance represents the first line of intracellular defence against virus infection. During herpes simplex virus type-1 (HSV-1) infection this response can lead to the repression of viral gene expression but is counteracted by the ...
Delphine Cuchet-Lourenço, Roger D Everett, Roger D. Everett, Boutell Chris, McFarlane Steven, Cuchet, D., Mandy Glass, Steven McFarlane, Cuchet-Lourenço Delphine, Chris Boutell, Glass, M., Vanni, E., Orr Anne, Everett Roger D., McFarlane, S., Everett, R.D., Glass Mandy, Vanni Emilia, Boutell, C., Emilia Vanni, Anne Orr, Orr, A.   +21 more
core   +1 more source

Determining the Critcial Size of EUV Mask Substrate Defects [PDF]

, 2008
Determining the printability of substrate defects beneath the extreme ultraviolet (EUV) reflecting multilayer stack is an important issue in EUVL lithography.
Han, Hakseung, Wurm, Stefan, Cho, Wonil, Jeon, Chan-Uk, Goldberg, Kenneth, Gullikson, Eric, Mccall, Monnikue M.   +6 more
core  

ERK2 suppresses self-renewal capacity of embryonic stem cells, but is not required for multi-lineage commitment.

PLoS ONE, 2013
Activation of the FGF-ERK pathway is necessary for naïve mouse embryonic stem (ES) cells to exit self-renewal and commit to early differentiated lineages.
William B Hamilton, Keisuke Kaji, Tilo Kunath   +2 more
doaj   +1 more source

Cross-Coupled Line Bandpass Filter Based on Modified Parallel-Coupled Line Structure

Jurnal Elektronika dan Telekomunikasi, 2022
This paper presents a study of a narrow bandwidth of the bandpass filter with a cross-coupled line structure. This structure was designed to have a good filter selectivity with the transmission zeros and a simple design.
Fajri Darwis, Enjel Al Birr Rahayu, Sutrisno Sutrisno, Hanny Madiawati, Taufiqqurrachman Taufiqqurrachman, Arie Setiawan, Erry Dwi Kurniawan, Yusuf Nur Wijayanto   +7 more
doaj   +1 more source