Results 111 to 120 of about 10,438,012 (377)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Substrate Specificity and Enzymatic Characteristics of Three Rutinosidases

Shipin gongye ke-ji
Quercetin, naringenin, and hesperetin are the hydrolysis products of rutinoside flavonoids, known for their multiple biological activities and potential applications.
Fengwei XIAO, Jiang SUN, Jiaying YE, Lijun LI, Hui NI   +4 more
doaj   +1 more source

Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2 [PDF]

, 2013
Metacaspases are cysteine peptidases found only in yeast, plants and lower eukaryotes, including the protozoa. To investigate the extended substrate specificity and effects of Ca²⁺ on the activation of these enzymes, detailed ...
Juliano, L., Juliano, M.A., Machado, M.K.M, Marcondes, M.F., McLuskey, K., Moss, C.X., Mottram, J.C., Oliveira, V.   +7 more
core   +1 more source

Inflammatory caspase substrate specificities

mBio
ABSTRACT Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes such as programmed cell death and inflammation. Extensive efforts have been made to identify caspase substrates and to determine factors that dictate substrate specificity ...
Patrick M. Exconde, Christopher M. Bourne, Madhura Kulkarni, Bohdana M. Discher, Cornelius Y. Taabazuing   +4 more
openaire   +3 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

A detailed analysis of the murine TAP transporter substrate specificity. [PDF]

PLoS ONE, 2008
The transporter associated with antigen processing (TAP) supplies cytosolic peptides into the endoplasmic reticulum for binding to major histocompatibility complex (MHC) class I molecules.
Anne Burgevin, Loredana Saveanu, Yohan Kim, Emilie Barilleau, Maya Kotturi, Alessandro Sette, Peter van Endert, Bjoern Peters   +7 more
doaj   +1 more source

Substrate and Donor Specificity of Glycosyl Transferases [PDF]

, 2018
It has been shown that all selectins recognize the carbohydrate epitopes sialyl Lewisx and sialyl Lewisa. For the establishment of the structure-activity relationship, the efficient synthesis of these tetrasaccharides and derivatives is therefore of ...
Ernst, Beat, Oehrlein, Reinhold
core  

Evolution of substrate specificity in a recipient's enzyme following horizontal gene transfer [PDF]

, 2013
Despite the prominent role of horizontal gene transfer (HGT) in shaping bacterial metabolism, little is known about the impact of HGT on the evolution of enzyme function.
Abascal, Aldo R. Camacho-Zarco, Barona-Gomez, Brune, Carver, Collaborative Computational Project, Number 4 (CCP4), Dean, Depristo, Des Marais, Dittmar, Due, Francisco Barona-Gómez, Glykos, Guindon, Henn-Sax, Hess, Hodgson, Hu, Hughes, Humphrey, Ikeda, James, Jensen, Jensen, Jones, Jorgensen, Jung, Kane, Klassen, Kuper, Leaver-Fay, Lerat, Lianet Noda-García, MacKerell, Mauricio Carrillo-Tripp, McCoy, Murshudov, Nester, Noda-Garcia, Ohno, Pal, Parish, Paul Gaytán, Perrakis, Piatigorsky, Sofía Medina-Ruíz, Sterner, Tokuriki, Tokuriki, Treangen, Vilmos Fülöp, Vriend, Wright, Xie, Xie   +54 more
core   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Substrate Specificity and Enzyme Recycling Using Chitosan Immobilized Laccase

Molecules, 2014
The immobilization of laccase (Aspergillus sp.) on chitosan by cross-linking and its application in bioconversion of phenolic compounds in batch reactors were studied.
Everton Skoronski, Mylena Fernandes, Maria de Lourdes Borba Magalhães, Gustavo Felippe da Silva, Jair Juarez João, Carlos Henrique Lemos Soares, Agenor Fúrigo Júnior   +6 more
doaj   +1 more source