Results 31 to 40 of about 10,558,845 (278)

Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. [PDF]

PLoS ONE, 2015
Protein tyrosine phosphatases dephosphorylate tyrosine residues of proteins, whereas, dual specificity phosphatases (DUSPs) are a subgroup of protein tyrosine phosphatases that dephosphorylate not only Tyr(P) residue, but also the Ser(P) and Thr(P ...
Bryan M Zhao, Sarah L Keasey, Joseph E Tropea, George T Lountos, Beverly K Dyas, Scott Cherry, Sreejith Raran-Kurussi, David S Waugh, Robert G Ulrich   +8 more
doaj   +1 more source

Predicting the substrate specificity of a glycosyltransferase implicated in the production of phenolic volatiles in tomato fruit [PDF]

, 2011
The volatile compounds that constitute the fruit aroma of ripe tomato (Solanum lycopersicum) are often sequestered in glycosylated form. A homology-based screen was used to identify the gene SlUGT5, which is a member of UDP-glycosyltransferase 72 family ...
Alba, Baldwin, Birtic, Bowles, Brazier-Hicks, Brazier-Hicks, Brazier-Hicks, Buttery, Chervin, Fleuriet, Fukuchi-Mizutani, Gachon, Hansen, Hefner, Jones, Jones, Jugdé, Kino, Lairson, Lairson, Lanot, Lanot, Li, Lim, Loutre, Lunkenbein, Marlatt, Morris, Ortiz-Serrano, Pang, Ross, Sali, Schuettelkopf, Shimoda, Smart, Song, Syahrani, Tikunov, Wang, Witte, Yoon, Zanor   +41 more
core   +1 more source

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

Nature Communications, 2019
PROteolysis-TArgeting Chimeras (PROTACs) are hetero-bifunctional molecules that recruit an E3 ubiquitin ligase to a given substrate protein resulting in its targeted degradation.
Blake E. Smith, Stephen L. Wang, S. Jaime-Figueroa, A. Harbin, Jing Wang, B. Hamman, C. Crews   +6 more
semanticscholar   +1 more source

Comparative Studies on Retroviral Proteases: Substrate Specificity

Viruses, 2010
Exogenous retroviruses are subclassified into seven genera and include viruses that cause diseases in humans. The viral Gag and Gag-Pro-Pol polyproteins are processed by the retroviral protease in the last stage of replication and inhibitors of the HIV-1
József Tözsér
doaj   +1 more source

Error thresholds for self- and cross-specific enzymatic replication [PDF]

, 2010
The information content of a non-enzymatic self-replicator is limited by Eigen's error threshold. Presumably, enzymatic replication can maintain higher complexity, but in a competitive environment such a replicator is faced with two problems related to ...
Acevedo, Alves, Baake, Benedikt Obermayer, Blythe, Campos, Cech, de Oliveira, Doudna, Eigen, Eigen, Erwin Frey, Fernando, Fontanari, Galluccio, Gerland, Gilbert, Hermisson, Huynen, Johnston, Joyce, Komarova, Kun, Leuthäusser, Lilley, Lincoln, Lässig, Maynard Smith, Michod, Nowak, Obermayer, Orgel, Orgel, Pace, Peliti, Rajamani, Rawlings, Saakian, Saakian, Schuster, Stadler, Stadler, Summers, Swetina, Szathmáry, Szostak, Takeuchi, Takeuchi, von Kiedrowski, Wagner, Weiner, Wiehe, Wilke, Wilke, Woodcock, Wu, Zaher   +56 more
core   +4 more sources

Proteomics profiling of arginine methylation defines PRMT5 substrate specificity

Science Signaling, 2019
Proteomics identifies target sites and substrates of the arginine methyltransferase PRMT5. Profiling PRMT5 The enzyme PRMT5 methylates arginine residues in target proteins to modify their function.
D. Musiani, Jabez Bok, Enrico Massignani, Liling Wu, Tommaso Tabaglio, M. Ippolito, A. Cuomo, U. Ozbek, Habiba Zorgati, Umesh Ghoshdastider, R. Robinson, E. Guccione, T. Bonaldi   +12 more
semanticscholar   +1 more source

Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R [PDF]

, 2000
Background: Vaccinia virus gene B1R encodes a erine/threonine protein kinase. In vitro this protein kinase phosphorylates ribosomal proteins Sa and S2 and vaccinia virus protein H5R, proteins that become phosphorylated during infection.
Beaud, G., Brown, N.G., Hardie, G., Leader, D.P., Morrice, D.N.   +4 more
core   +3 more sources

Substrate specificity of human MCPIP1 endoribonuclease

Scientific Reports, 2018
MCPIP1, also known as Regnase-1, is a ribonuclease crucial for regulation of stability of transcripts related to inflammatory processes. Here, we report that MCPIP1 acts as an endonuclease by degrading several stem-loop RNA structures and single-stranded
Mateusz Wilamowski, Andrzej Gorecki, Marta Dziedzicka-Wasylewska, Jolanta Jura   +3 more
doaj   +1 more source

Crystal Structure and Substrate Specificity of PTPN12

Cell Reports, 2016
PTPN12 is an important tumor suppressor that plays critical roles in various physiological processes. However, the molecular basis underlying the substrate specificity of PTPN12 remains uncertain.
Hui Li, Fan Yang, Chunhua Liu, Peng Xiao, Yunfei Xu, Zonglai Liang, Chuan Liu, Hongmei Wang, Wenjun Wang, Wenshuai Zheng, Wei Zhang, Xiaoyun Ma, Dongfang He, Xiaoyuan Song, Fuai Cui, Zhigang Xu, Fan Yi, Jin-Peng Sun, Xiao Yu   +18 more
doaj   +1 more source

Substrate specificity in the biomimetic catalytic aerobic oxidation of styrene and cyclohexanone by metalloporphyrins: kinetics and mechanistic study

Green Chemical Engineering, 2021
Substrate specificity is a hallmark of enzymatic catalysis. In this work, the biomimetic catalytic oxidation of styrene and cyclohexanone by iron (III) porphyrins and molecular oxygen was carried out, and remarkable differences in efficiency were ...
Xian-Tai Zhou, Hong-Bing Ji
doaj   +1 more source