Results 41 to 50 of about 10,438,012 (377)
Substrate Specificity in Thiol Dioxygenases.
Biochemistry, 2019 Thiol dioxygenases make up a class of ferrous iron-dependent enzymes that oxidize thiols to their corresponding sulfinates. X-ray diffraction structures of cysteine-bound cysteine dioxygenase show how cysteine is coordinated via its thiolate and amine to
Sekotilani Aloi +4 more
semanticscholar +1 more source
On the substrate specificity of human CYP27A1
Journal of Lipid Research, 2003 The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due
Maria Norlin +3 more
doaj +1 more source
Biomolecules, 2022 Jumonji C (JmjC) lysine demethylases (KDMs) catalyze the removal of methyl (-CH3) groups from modified lysyl residues. Several JmjC KDMs promote cancerous properties and these findings have primarily been in relation to histone demethylation.
Anand Chopra +2 more
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Elucidation of substrate specificity in Aspergillus nidulans UDP-galactose-4-epimerase. [PDF]
PLoS ONE, 2013 The frequency of invasive fungal infections has rapidly increased in recent years. Current clinical treatments are experiencing decreased potency due to severe host toxicity and the emergence of fungal drug resistance.
Sean A Dalrymple +4 more
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Substrate Specificity of Chlorophyllase [PDF]
Plant Physiology, 1975 Apparent Km and V(max) values were obtained for hydrolysis of methyl and ethyl chlorophyllides a, methyl and ethyl pheophorbide a, and 9-hydroxymethyl pheophorbide a by chlorophyllase from Ailanthus altissima. Analysis of substrate specificity data for chlorophyllase indicates that the presence of a 9-keto group and a methyl alcohol group esterified at
openaire +3 more sources
Crystal Structure and Substrate Specificity of PTPN12
Cell Reports, 2016 PTPN12 is an important tumor suppressor that plays critical roles in various physiological processes. However, the molecular basis underlying the substrate specificity of PTPN12 remains uncertain.
Hui Li +18 more
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Origin and evolution of transporter substrate specificity within the NPF family
eLife, 2017 Despite vast diversity in metabolites and the matching substrate specificity of their transporters, little is known about how evolution of transporter substrate specificities is linked to emergence of substrates via evolution of biosynthetic pathways ...
M. E. Jørgensen +9 more
semanticscholar +1 more source
Substrate Specificity of Recombinant Ser/Thr Protein Kinase
Bio-Protocol, 2015 Protein kinases are enzymes that phosphorylate proteins in a cell. Determination of kinase activity in reactions of phosphorylation is a very convenient way for a biochemical characterization of this group of enzymes.
Anna Zorina, Galina Novikova, Dmitry Los
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Substrate specificity of the ubiquitin and Ubl proteases
Cell Research, 2016 Conjugation and deconjugation of ubiquitin and ubiquitin-like proteins (Ubls) to cellular proteins are highly regulated processes integral to cellular homeostasis.
J. Ronau, J. Beckmann, M. Hochstrasser
semanticscholar +1 more source
Journal of Lipid Research, 1993 In this study we used monoacid triacylglycerols of various acyl-chain lengths as substrates for probing the active-site structure and substrate specificity of lipoprotein lipase (LPL).
Chi-Sun Wang +3 more
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