Results 51 to 60 of about 792,149 (335)
Computational and Structural Biotechnology Journal, 2020 Transport of ligands between bulk solvent and the buried active sites is a critical event in the catalytic cycle of many enzymes. The rational design of transport pathways is far from trivial due to the lack of knowledge about the effect of mutations on ...
Piia Kokkonen +8 more
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The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F [PDF]
, 2009 Receptor-linked protein-tyrosine phosphatases (RPTPs) are essential regulators of axon guidance and synaptogenesis in Drosophila, but the signaling pathways in which they function are poorly defined.
Bugga, Lakshmi +2 more
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Probabilistic approach to predicting substrate specificity of methyltransferases.
PLoS Computational Biology, 2014 We present a general probabilistic framework for predicting the substrate specificity of enzymes. We designed this approach to be easily applicable to different organisms and enzymes.
Teresa Szczepińska +7 more
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Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase. [PDF]
PLoS ONE, 2010 3,4-Dihydroxyphenylalanine decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, catalyzes the decarboxylation of a number of aromatic L-amino acids.
Qian Han +4 more
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Substrate Specificity of Peptide Adsorption: A Model Study
, 2007 Applying the contact density chain-growth algorithm to lattice heteropolymers, we identify the conformational transitions of a nongrafted hydrophobic-polar heteropolymer with 103 residues in the vicinity of a polar, a hydrophobic, and a uniformly ...
L. Toma +2 more
core +1 more source
Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase. [PDF]
, 2019 Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- and ...
Aleem, Ansari Mukhtar +7 more
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Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2 [PDF]
, 2013 Metacaspases are cysteine peptidases found only in yeast, plants and lower eukaryotes, including the protozoa. To investigate the extended substrate specificity and effects of Ca<sup>2+</sup> on the activation of these enzymes, detailed ...
Juliano, L. +7 more
core +1 more source
On the substrate specificity of glucose oxidase
Biochimica et Biophysica Acta, 1957 Peer ...
Gertrudis de la Fuente, Alberto Sols
openaire +4 more sources
The generation of latent-ion-transport capacity [PDF]
, 1959 Of the various hypotheses designed to explain the movement of ions from the environment into the plant cell, the most attractive suggests that ions traverse cell membranes in combination with an endogenously produced carrier substance.(1,2) The ...
Laties, George G.
core +1 more source
Structural basis for substrate specificity of mammalian neuraminidases.
PLoS ONE, 2014 The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes.
Victoria Smutova +7 more
doaj +1 more source