Results 41 to 50 of about 1,995,516 (278)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Disulfide bonds are critical for stabilizing cell division, cell envelope biogenesis, and antibiotic resistance proteins in mycobacteria

mBio
Mycobacteria, including Mycobacterium tuberculosis—the etiological agent of tuberculosis—possess a unique and impermeable cell envelope that is critical for survival and antibiotic resistance.
Adrian Mejia-Santana, Rebecca Collins, Emma H. Doud, Cristina Landeta   +3 more
doaj   +1 more source

Measuring Gaussian rigidity using curved substrates [PDF]

, 2020
The Gaussian (saddle splay) rigidity of fluid membranes controls their equilibrium topology but is notoriously difficult to measure. In lipid mixtures, typical of living cells, linear interfaces separate liquid ordered (LO) from liquid disordered (LD ...
Al-Izzi, Sami C., Fonda, Piermarco, Giomi, Luca, Turner, Matthew S.   +3 more
core   +3 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Solid-state dewetting on curved substrates

, 2018
Based on the thermodynamic variation to the free energy functional, we propose a sharp-interface model for simulating solid-state dewetting of thin films on rigid curved substrates in two dimensions.
Bao, Weizhu, Jiang, Wei, Srolovitz, David J., Wang, Yan   +3 more
core   +1 more source

Faunal response to benthic and hyporheic sedimentation varies with direction of vertical hydrological exchange [PDF]

, 2014
1. Sedimentation and clogging of benthic and hyporheic zone substrates is increasingly being recognised as one of the greatest threats to the ecological integrity of riverine ecosystems globally. This ex-situ study examined the influence of sedimentation
Bo, Boano, Boulton, Boulton, Boulton, Brunke, Brunke, Bruno, Collins, Davy-Bowker, Descloux, Descloux, Descloux, Dole-Oliver, Dunbar, Evans, Extence, Fowler, Franken, Gayraud, Gledhill, Greig, Huettel, IBM Corp, Izagirre, Jones, Jones, Joyce, Kemp, Krause, Larned, Larson, MacNeil, MacNeil, Malcolm, Maridet, Navel, Olsen, Pacioglu, Packman, Packman, Pepin, Plenet, Ren, Richards, Robertson, Ryan, Sarriquet, Simpson, Studinski, Stump, Taylor, Walters, Wang, Weigelhofer, Wood, Wood, Xu, Zweig   +58 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Teline monspessulana Can Harm the Chilean Native Tree Nothofagus obliqua: Effects on Germination and Initial Growth

Plants, 2023
Teline monspessulana is highly invasive in several countries around the world. This species pressurizes and displaces several native and endemic tree species in south-central Chile such as Nothofagus obliqua, the native species of greatest timber ...
Narciso Aguilera, Lubia M. Guedes, Ulises Alvarado, Katia Sáez-Carrillo   +3 more
doaj   +1 more source

Silicon-slurry/aluminide coating [PDF]

, 1983
A low cost coating protects metallic base system substrates from high temperatures, high gas velocity ovidation, thermal fatigue and hot corrosion and is particularly useful fo protecting vanes and blades in aircraft and land based gas turbine engines. A
Deadmore, D. L., Young, S. G.
core   +1 more source

Active Matter on Asymmetric Substrates

, 2011
For collections of particles in a thermal bath interacting with an asymmetric substrate, it is possible for a ratchet effect to occur where the particles undergo a net dc motion in response to an ac forcing.
Drocco, J., Mai, T., Reichhardt, C., Reichhardt, C. J. Olson, Wan, M. B.   +4 more
core   +1 more source