Results 91 to 100 of about 17,568 (222)

Beta‐Band and Aperiodic Activity Across New and Chronic Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Neurophysiological biomarkers in Parkinson's disease (PD) are increasingly used for deep brain stimulation (DBS). Their long‐term utility is not clear, especially when transitioning to sensing‐guided DBS years post‐surgery. Objectives Beta‐band power, bursting activity, and periodic and aperiodic components of local field potentials
Arjun Balachandar, Alexandra Boogers, Sara Naghdlou, Andres M. Lozano, Suneil K. Kalia, Gerd Tinkhauser, Alfonso Fasano   +6 more
wiley   +1 more source

Quantitative Analysis of Locus Coeruleus Neurons and Thalamic Noradrenergic Axons in a Progressive 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine Monkey Model of Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease is mainly characterized by dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) and α‐synuclein accumulation. The locus coeruleus (LC) is also affected in Parkinson's disease and linked to some nonmotor symptoms, but the extent and timing of its degeneration remain unclear.
Megan Carrillo, Nagore Hernández‐Pinedo, Josefa Zaldivar‐Diez, Isabel Pérez‐Santos, José A. Obeso, Carmen Cavada, Javier Blesa   +6 more
wiley   +1 more source

In Vivo Mapping of Catecholaminergic Loss and Iron Deposition in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background The pathophysiology of Huntington's disease (HD) remains obscure. Magnetic resonance imaging (MRI) can reveal in vivo molecular changes related to disease pathology. Objectives To investigate catecholaminergic neuronal integrity and subcortical brain iron accumulation in HD employing neuromelanin‐sensitive MRI, and quantitative ...
Edoardo R. de Natale, Heather Wilson, Efstratios Karavasilis, Athanasia Liozidou, Chrisoula Kartanou, Georgios Velonakis, Jens Kuhle, Ioannis Zalonis, Georgia Karadima, Leonidas Stefanis, Georgios Koutsis, Marios Politis   +11 more
wiley   +1 more source

Abrupt Reoccurrence of Acquired Postencephalitic Hemidystonia After Unexpected Discontinuation of Thalamic DBS: An Embarrassing Situation

Movement Disorders Clinical Practice, EarlyView.
Arif Abdulbaki, Joachim Runge, Assel Saryyeva, Joachim K. Krauss   +3 more
wiley   +1 more source

Patient‐Reported Feedback Suggests an Alternative Sweet Spot for Deep Brain Stimulation Programming in Essential Tremor

Movement Disorders, EarlyView.
(1) To sample subjective patient rating using the Visual Analogue Scale (VAS), random stimulation parameters were presented to the study subjects. (2) Next, corresponding volumes of tissue activated (VTA) were generated and paired with VAS values.
Sophia Peschke, Jing Dong, Angelina Kirschner, Johannes Off, Juhi Shaik, Carla Palleis, Jan Hinnerk Mehrkens, Elisabeth Kaufmann, Maximilian Scherer, Thomas Koeglsperger   +9 more
wiley   +1 more source

POLG‐Related Parkinsonism with Good Response to Deep Brain Stimulation

Movement Disorders Clinical Practice, EarlyView.
Evdokia Efthymiou, Fabian Büchele, Sujitha Mahendran, Lennart Stieglitz, Bettina Balint   +4 more
wiley   +1 more source

Aberrant Beta‐Band Network Alteration Preceding Freezing of Gait in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Freezing of gait (FOG) is a debilitating motor symptom observed in the advanced stages of Parkinson's disease (PD), characterized by an abrupt inability to initiate or continue forward walking. Whole‐brain functional connectivity analysis has shown promise in elucidating the underlying pathophysiology and identifying potential ...
Yanqiu Tian, Elie Matar, Shlomo Berkovsky, Simon J.G. Lewis   +3 more
wiley   +1 more source

Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Aperiodic spectral broadband power has been described recently as reflecting Parkinson's disease (PD) severity. It has therefore become an increasing focus of research interest in the context of the new adaptive deep brain stimulation (DBS) approach.
Martin Lamoš, Aneta Žáčková, David Ulčák, Benjamin Gurka, Daniel Brzuchanski, Lucia Šmahovská, Martina Bočková   +6 more
wiley   +1 more source

Framework for Approaching Patients with Suboptimal Deep Brain Stimulation Therapy Response despite Stimulation Optimization

Movement Disorders Clinical Practice, EarlyView.
Pratik Talati, Meredith Spindler, Casey H. Halpern   +2 more
wiley   +1 more source

When the Scale Drops: Pathways to Weight Loss in Parkinson's Disease and Future Directions

Movement Disorders, EarlyView.
Abstract Although Parkinson's disease (PD) is classically defined by its motor features, non‐motor symptoms exert a substantial and often under‐recognized influence on disease trajectory. Among these, weight loss has long been observed in PD and other neurodegenerative disorders, yet the mechanisms remain incompletely understood.
Ellie D. Gabriel, Robert S. Eisinger, Joyce M. Lee, Sarah Hamimi, Hope Kim, Susanna D. Howard, Casey H. Halpern   +6 more
wiley   +1 more source