Results 91 to 100 of about 41,423 (288)

Adaptive Deep Brain Stimulation Benefits: Younger Patients with Persistent Wearing‐off Symptoms

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) often involves motor fluctuations and dyskinesia, which are difficult to manage with medication alone. Conventional deep brain stimulation (cDBS) effectively alleviates symptoms but has limitations, including the challenge of balancing therapeutic effects against potential side effects, as well as limited ...
Takuto Emura, Naoki Tani, Koichi Hosomi, Yuki Kimoto, Takahiro Matsuhashi, Takahiro Fujinaga, Shimpei Miura, Yuya Fujita, Nobuhiko Mori, Hui Ming Khoo, Satoru Oshino, Haruhiko Kishima   +11 more
wiley   +1 more source

Quantifying local field potential dynamics with amplitude and frequency stability between ON and OFF medication and stimulation in Parkinson's disease

Neurobiology of Disease
Neural oscillations are critical to understanding the synchronisation of neural activities and their relevance to neurological disorders. For instance, the amplitude of beta oscillations in the subthalamic nucleus has gained extensive attention, as it ...
Xuanjun Guo, Shenghong He, Xinyi Geng, Pan Yao, Christoph Wiest, Yingnan Nie, Huiling Tan, Shouyan Wang   +7 more
doaj   +1 more source

Desynchronizing effect of high-frequency stimulation in a generic cortical network model

, 2012
Transcranial Electrical Stimulation (TCES) and Deep Brain Stimulation (DBS) are two different applications of electrical current to the brain used in different areas of medicine. Both have a similar frequency dependence of their efficiency, with the most
A Antal, A Antal, A Benabid, A Compte, A Gupta, A Limoge, A Limoge, A Sances Jr, AS Pikovsky, B Nuttin, C Börgers, CC McIntyre, E Schöll, EM Izhikevich, EM Izhikevich, EM Izhikevich, EM Izhikevich, F Velasco, H Markram, J Lian, J Yianni, JA Acebrón, JA Obesó, JD Geyer, Jens Christian Claussen, JL Houeto, KJ Ressler, L Gang, L Garcia, M Steriade, Markus Schütt, P Coubes, R Kumar, R Wang, SC Bellinger, TR Anderson, V Visser-Vandewalle, X Zhang, Y Liu, Y Su   +39 more
core   +1 more source

Deep Brain Stimulation in a Child with Aicardi‐Goutières Syndrome‐7 (AGS7): A Case Report and Literature Review

Movement Disorders Clinical Practice, EarlyView.
Sangeetha Yoganathan, Siddharth Seth, Sunita Venkateswaran, Wei Kang Lim, Andrea LeBlanc‐Millar, Sara Breitbart, Vivek Pai, Asif Doja, Alfonso Fasano, George M. Ibrahim, Carolina Gorodetsky   +10 more
wiley   +1 more source

Motor and Cognitive Outcome After Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson's Disease Harboring GBA1 Variant

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Deep brain stimulation (DBS) is effective for Parkinson's disease (PD); however, its efficacy varies with genetic background, such as the GBA1 variant—the causative gene of Gaucher disease—associated with increased PD risk and cognitive decline after subthalamic nucleus (STN)‐DBS.
Hikaru Kamo, Genko Oyama, Mai Shimizu, Haruka Takeshige‐Amano, Takashi Ogawa, Wataru Sako, Noriko Nishikawa, Taku Hatano, Yuanzhe Li, Hiroyo Yoshino, Manabu Funayama, Masanobu Ito, Hirokazu Iwamuro, Atsushi Umemura, Nobutaka Hattori   +14 more
wiley   +1 more source

Modeling effect of GABAergic current in a basal ganglia computational model

, 2012
Electrical high frequency stimulation (HFS) of deep brain regions is a method shown to be clinically effective in different types of movement and neurological disorders.
Claussen, Jens Christian, Hofmann, Ulrich G., Moser, Andreas, Njap, Felix   +3 more
core   +1 more source

Finely Tuned Gamma Oscillations in the Globus Pallidus Internus in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Hikaru Kamo, Mallory L.S. Eisel, Jackson N. Cagle, Kara A. Johnson, Joshua Wong, Coralie de Hemptinne   +5 more
wiley   +1 more source

A Novel α‐Synuclein K58N Missense Variant in a Patient with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a complex multifactorial disorder with a genetic component in about 15% of cases. Multiplications and point mutations in SNCA gene, encoding α‐synuclein (aSyn), are linked to rare familial forms of PD. Objective Our goal was to assess the clinical presentation and the biological effects of a novel K58N ...
Mohammed Al‐Azzani, Sandrina Weber, Nagendran Ramalingam, Maria Ramón, Liana Shvachiy, Gonçalo Mestre, Michael Zech, Kevin Sicking, Alain Ibáñez de Opakua, Vidyashree Jayanthi, Leslie Amaral, Aishwarya Agarwal, Aswathy Chandran, Susana R. Chaves, Juliane Winkelmann, Claudia Trenkwalder, Maike Schwager, Silke Pauli, Ulf Dettmer, Claudio O. Fernández, Janin Lautenschläger, Markus Zweckstetter, Ruben Fernandez‐Busnadiego, Brit Mollenhauer, Tiago Fleming Outeiro   +24 more
wiley   +1 more source

How to run a brain bank. A report from the Austro-German brain bank [PDF]

, 1993
The sophisticated analysis of and growing information on the human brain requires that acquisition, dissection, storage and distribution of rare material are managed in a professional way.
Gsell, W., Heckers, S., Heinsen, H., Jellinger, K., Lange, Klaus W., Pfeuffer, R., Ransmayr, G., Senitz, D., Vock, R., Wichart, I.   +9 more
core  

Cortical and Corticomuscular Beta‐Gamma Phase‐Amplitude Coupling During Different Locomotion States and the Effects of Levodopa in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Phase‐amplitude coupling (PAC) in the beta‐gamma range has emerged as a promising electrophysiological biomarker of Parkinson's disease (PD). Objective This study aims to investigate how levodopa and locomotion modulate cortical (central electroencephalogram [cEEG]) and corticomuscular (cEEG‐gEMG [gastrocnemius electromyography ...
Haifeng Zhao, Shenglin Hao, Peiran Zhang, Shenghong He, Laura Wehmeyer, Ziyi Feng, Lu Xu, Shikun Zhan, Wei Liu, Xiaoxiao Zhang, Marie‐Laure Welter, Dianyou Li, Bomin Sun, Yong Lu, Huiling Tan, Chunyan Cao   +15 more
wiley   +1 more source