Results 91 to 100 of about 490,973 (323)

Totally Implantable Bidirectional Neural Prostheses: A Flexible Platform for Innovation in Neuromodulation. [PDF]

open access: yes, 2018
Implantable neural prostheses are in widespread use for treating a variety of brain disorders. Until recently, most implantable brain devices have been unidirectional, either delivering neurostimulation without brain sensing, or sensing brain activity to
Starr, Philip A
core   +2 more sources

Morphological changes of glutamatergic synapses in animal models of Parkinson’s disease

open access: yesFrontiers in Neuroanatomy, 2015
The striatum and the subthalamic nucleus are the main entry doors for extrinsic inputs to reach the basal ganglia circuitry. The cerebral cortex, thalamus and brainstem are the key sources of glutamatergic inputs to these nuclei.
Rosa M Villalba   +6 more
doaj   +1 more source

Directional deep brain stimulation of the subthalamic nucleus: A pilot study using a novel neurostimulation device

open access: yesMovement Disorders, 2016
A novel neurostimulation system allows steering current in horizontal directions by combining segmented leads and multiple independent current control.
F. Steigerwald   +4 more
semanticscholar   +1 more source

Synaptic release of dopamine in the subthalamic nucleus

open access: yesEuropean Journal of Neuroscience, 2004
AbstractThe direct modulation of subthalamic nucleus (STN) neurons by dopamine (DA) neurons of the substantia nigra (SN) is controversial owing to the thick caliber and low density of DA axons in the STN. The abnormal activity of the STN in Parkinson's disease (PD), which is central to the appearance of symptoms, is therefore thought to result from the
J. Paul Bolam   +6 more
openaire   +3 more sources

Mapping the landscape of brain stimulation research: A global scientometric review on cognitive impairment

open access: yesIbrain, EarlyView.
This study maps global trends in brain stimulation research for cognitive impairment using bibliometric analysis of 4156 records (1989–2024, WoSCC). Findings highlight the dominance of transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS), emerging vascular‐focused research, and promising techniques like fast gamma magnetic stimulation and ...
Mani Abdul Karim
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

open access: yesBritish Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi   +6 more
wiley   +1 more source

Imaging the Centromedian Thalamic Nucleus Using Quantitative Susceptibility Mapping. [PDF]

open access: yes, 2019
The centromedian (CM) nucleus is an intralaminar thalamic nucleus that is considered as a potentially effective target of deep brain stimulation (DBS) and ablative surgeries for the treatment of multiple neurological and psychiatric disorders.
Gutierrez, Lorenzo   +9 more
core  

Characterizing the spiking dynamics of subthalamic nucleus neurons in Parkinson's disease using generalized linear models

open access: yesFrontiers in Integrative Neuroscience, 2012
Accurately describing the spiking patterns of neurons in the subthalamic nucleus of patients suffering from Parkinson’s disease is important for understanding the pathogenesis of the disease and for achieving the maximum therapeutic benefit from deep ...
Uri eEden   +3 more
doaj   +1 more source

Phase matters: A role for the subthalamic network during gait. [PDF]

open access: yesPLoS ONE, 2018
The role of the subthalamic nucleus in human locomotion is unclear although relevant, given the troublesome management of gait disturbances with subthalamic deep brain stimulation in patients with Parkinson's disease.
Gabriele Arnulfo   +9 more
doaj   +1 more source

Local vs. volume conductance activity of field potentials in the human subthalamic nucleus.

open access: yesJournal of Neurophysiology, 2017
Subthalamic nucleus field potentials have attracted growing research and clinical interest over the last few decades. However, it is unclear whether subthalamic field potentials represent locally generated neuronal subthreshold activity or volume ...
O. Marmor   +8 more
semanticscholar   +1 more source

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