Results 101 to 110 of about 502,362 (345)

Characterizing the spiking dynamics of subthalamic nucleus neurons in Parkinson's disease using generalized linear models

open access: yesFrontiers in Integrative Neuroscience, 2012
Accurately describing the spiking patterns of neurons in the subthalamic nucleus of patients suffering from Parkinson’s disease is important for understanding the pathogenesis of the disease and for achieving the maximum therapeutic benefit from deep ...
Uri eEden   +3 more
doaj   +1 more source

Phase matters: A role for the subthalamic network during gait. [PDF]

open access: yesPLoS ONE, 2018
The role of the subthalamic nucleus in human locomotion is unclear although relevant, given the troublesome management of gait disturbances with subthalamic deep brain stimulation in patients with Parkinson's disease.
Gabriele Arnulfo   +9 more
doaj   +1 more source

Neurobiological correlates of obsessive‐compulsive disorder (OCD): A narrative review

open access: yesIbrain, EarlyView.
Obsessive‐compulsive disorder (OCD) is a common and disabling, as well as underdiagnosed, neuropsychiatric condition characterized by involuntary and unwanted obsessions and/or compulsions often accompanied by states of severe anxiety, distress and shame, as well as other comorbid disorders. Despite the extensive literature available to date, only some
Giulio Perrotta, Anna Sara Liberati
wiley   +1 more source

Deep Brain Stimulation Reduces Conflict‐Related Theta and Error‐Related Negativity in Patients With Obsessive–Compulsive Disorder

open access: yesNeuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Obsessive–compulsive disorder (OCD) is a psychiatric disorder with alterations of cortico‐striato‐thalamo‐cortical loops and impaired performance monitoring. Electrophysiological markers such as conflict‐related medial frontal theta (MFT) and error‐related negativity (ERN) may be altered by clinically effective deep brain ...
Elena Sildatke   +9 more
wiley   +1 more source

Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease. [PDF]

open access: yesPLoS ONE, 2012
The aim of our study was to assess changes in body-weight in relation to active electrode contact position in the subthalamic nucleus. Regular body weight measurements were done in 20 patients with advanced Parkinson's disease within a period of 18 ...
Filip Růžička   +5 more
doaj   +1 more source

Cortical and Striatal Circuits in Huntington's Disease

open access: yes, 2020
Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically manifests in midlife with motor, cognitive, and/or psychiatric symptoms.
Blumenstock, S., Dudanova, I.
core   +1 more source

The Mild Behavioral Impairment Checklist for Parkinson's Disease: An Ancillary Instrument in Cognitive Assessment

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Mild behavioral impairment (MBI) is a syndrome characterized by the later‐life onset of neuropsychiatric symptoms (NPS) and serves as a potential marker for dementia. In Parkinson's disease (PD), MBI has been associated with worse cognition, cortical atrophy, and altered connectivity.
Gabriel D. Pinilla‐Monsalve   +4 more
wiley   +1 more source

Deep Brain Stimulation of Caudal Zona Incerta for Parkinson's Disease: One‐Year Follow‐Up and Electric Field Simulations

open access: yesNeuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective To evaluate the effects of bilateral caudal zona incerta (cZi) deep brain stimulation (DBS) for Parkinson's disease (PD) one year after surgery and to create anatomical improvement maps based on patient‐specific simulation of the electric field.
Rasmus Stenmark Persson   +6 more
wiley   +1 more source

Closed-loop deep brain stimulation based on a stream-clustering system [PDF]

open access: yes, 2019
Idiopathic Parkinsons disease (PD) is currently the second most important neurodegenerative disease in incidence. Deep brain stimulation (DBS) constitutes a successful and necessary therapy; however, the continuous stimulation it provides can be ...
Aziz, Tipu   +4 more
core   +1 more source

Local Field Potential‐Based Programming: A Proof‐of‐Concept Pilot Study

open access: yesNeuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Programming deep brain stimulation (DBS) is still based on a trial‐and‐error approach, often becoming a time‐consuming process for both treating physicians and patients. Several strategies have been proposed to streamline DBS programming, most of which are preliminary and mainly address Parkinson's disease, a condition readily ...
Alfonso Fasano   +10 more
wiley   +1 more source

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