Deep brain stimulation for movement disorder treatment: Exploring frequency-dependent efficacy in a computational network model [PDF]
A large scale computational model of the basal ganglia (BG) network is proposed to describes movement disorder including deep brain stimulation (DBS). The model of this complex network considers four areas of the basal ganglia network: the subthalamic nucleus (STN) as target area of DBS, globus pallidus, both pars externa and pars interna (GPe-GPi ...
arxiv
A Multiple Kernel Learning Approach for Human Behavioral Task Classification using STN-LFP Signal [PDF]
Deep Brain Stimulation (DBS) has gained increasing attention as an effective method to mitigate Parkinsons disease (PD) disorders. Existing DBS systems are open-loop such that the system parameters are not adjusted automatically based on patients behavior. Classification of human behavior is an important step in the design of the next generation of DBS
arxiv +1 more source
Physical therapy and deep brain stimulation in Parkinson’s Disease: Protocol for a pilot randomized controlled trial [PDF]
Background Subthalamic nucleus deep brain stimulation (STN-DBS) reduces tremor, muscle stiffness, and bradykinesia in people with Parkinson’s Disease (PD).
Duncan, Ryan P+4 more
core +2 more sources
Local vs. volume conductance activity of field potentials in the human subthalamic nucleus.
Subthalamic nucleus field potentials have attracted growing research and clinical interest over the last few decades. However, it is unclear whether subthalamic field potentials represent locally generated neuronal subthreshold activity or volume ...
O. Marmor+8 more
semanticscholar +1 more source
Dyskinesias and the subthalamic nucleus.
Severe dyskinesias or ballism can occur following hemorrhagic events in the subthalamic nucleus (STN), and it has recently been established that the STN plays a major role in the pathophysiology of the motor dysfunction of Parkinson's disease (PD) and that STN inhibition improves parkinsonian dysfunction.
Benabid, A L+6 more
openaire +2 more sources
Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits [PDF]
Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD).
Bucklin, Mark+5 more
core +1 more source
Magnetic resonance imaging of the subthalamic nucleus for deep brain stimulation.
The subthalamic nucleus (STN) is one of the most important stereotactic targets in neurosurgery, and its accurate imaging is crucial. With improving MRI sequences there is impetus for direct targeting of the STN.
Arjun S. Chandran, M. Bynevelt, C. Lind
semanticscholar +1 more source
Acute hemiballismus in the absence of subthalamic nucleus lesion
A 68-year-old male, known hypertensive on irregular medication presented with sudden onset of involuntary movements of the left upper limb, in the form of severely violent, arrhythmic, and flinging large amplitude movements for 2 days, suggestive of ...
Shreya Gudi+2 more
doaj +1 more source
Continuous Dice Coefficient: a Method for Evaluating Probabilistic Segmentations [PDF]
Objective: Overlapping measures are often utilized to quantify the similarity between two binary regions. However, modern segmentation algorithms output a probability or confidence map with continuous values in the zero-to-one interval. Moreover, these binary overlapping measures are biased to structure size.
arxiv
Totally Implantable Bidirectional Neural Prostheses: A Flexible Platform for Innovation in Neuromodulation. [PDF]
Implantable neural prostheses are in widespread use for treating a variety of brain disorders. Until recently, most implantable brain devices have been unidirectional, either delivering neurostimulation without brain sensing, or sensing brain activity to
Starr, Philip A
core +2 more sources