Results 101 to 110 of about 489,097 (277)

Dynamic control of decision and movement speed in the human basal ganglia

Nature Communications, 2022
The neural mechanisms determining the speed of decisions and movements in the human brain remain poorly understood. Here, the authors reveal that the subthalamic nucleus causally controls decision and movement speed independently for each hemisphere.
Damian M. Herz, Manuel Bange, Gabriel Gonzalez-Escamilla, Miriam Auer, Keyoumars Ashkan, Petra Fischer, Huiling Tan, Rafal Bogacz, Muthuraman Muthuraman, Sergiu Groppa, Peter Brown   +10 more
doaj   +1 more source

Decisional impulsivity and the associative-limbic subthalamic nucleus in obsessive-compulsive disorder: stimulation and connectivity

Brain : a journal of neurology, 2016
Why do we make hasty decisions for short-term gain? Rapid decision-making with limited accumulation of evidence and delay discounting are forms of decisional impulsivity.
V. Voon, F. Droux, L. Morris, S. Chabardès, T. Bougerol, O. David, P. Krack, M. Polosan   +7 more
semanticscholar   +1 more source

The Intraoperative Microlesion Effect Positively Correlates With the Short‐Term Clinical Effect of Deep Brain Stimulation in Parkinson's Disease

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective During the surgical procedure of deep brain stimulation (DBS), insertion of an electrode in the subthalamic nucleus (STN) frequently causes a temporary improvement of motor symptoms, known as the microlesion effect (MLE). The objective of this study was to determine the correlation between the intraoperative MLE and the clinical ...
Stèfan F. Lange, Naomi I. Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam‐Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost   +8 more
wiley   +1 more source

Evaluation of spike sorting algorithms: Simulations and application to human Subthalamic Nucleus recordings [PDF]

arXiv, 2018
An important prerequisite for the analysis of spike synchrony in extracellular recordings is the extraction of single unit activity from the recorded multi unit signal. To identify single units (SUs), potential spikes are detected and separated with respect to their potential neuronal origins ('spike sorting').
arxiv  

Clinical and Imaging Correlates of Medication Reduction in Globus Pallidus Stimulation for Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The magnitude and factors associated with levodopa equivalent daily dose (LEDD) reduction in deep brain stimulation (DBS) of the globus pallidus interna (GPi) for Parkinson's Disease (PD) remain unclear. Objective To investigate LEDD reduction in GPi DBS and its correlation with anatomical/clinical characteristics.
Daniel G. Di Luca, Carolina Ramirez‐Gomez, Brendan Santyr, Marco Fumagalli, Jürgen Germann, Suneil K. Kalia, Andres M. Lozano, Alfonso Fasano   +7 more
wiley   +1 more source

The human subthalamic nucleus encodes the subjective value of reward and the cost of effort during decision-making.

Brain : a journal of neurology, 2016
Adaptive behaviour entails the capacity to select actions as a function of their energy cost and expected value and the disruption of this faculty is now viewed as a possible cause of the symptoms of Parkinson's disease.
A. Zénon, Y. Duclos, R. Carron, T. Witjas, C. Baunez, J. Régis, J. Azulay, P. Brown, A. Eusebio   +8 more
semanticscholar   +1 more source

Prevalence and Clinical Characteristics of the LRRK2 p.L1795F Variant in Central Europeans with Early‐Onset and Familial Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Leucine‐rich repeat kinase 2 (LRRK2) p.L1795F variant was proposed as a genetic risk factor for Parkinson's disease (PD). However, its prevalence, phenotype, and origin remain unknown. Objective The aim was to evaluate the frequency and phenotype of p.L1795F in early‐onset PD (EOPD) and familial PD compared to healthy controls (HC ...
Miriam Ostrozovicova, Gertrud Tamas, Agsha Atputhavadivel, Petr Dusek, Milan Grofik, Vladimir Han, Petr Holly, Robert Jech, Katarina Kalinova, Peter Klivenyi, Norbert Kovacs, Kristina Kulcsarova, Egon Kurca, Alexandra Lackova, Hamin Lee, Patrick Lewis, Veronika Magocova, Maria Marekova, David Murphy, Ai Nagano, Jan Necpal, David Pinter, Miroslava Rabajdova, Evzen Ruzicka, Tereza Serranova, Katarzyna Smilowska, Krisztina Soos, Igor Straka, Tatiana Svorenova, Peter Valkovic, Katerina Zarubova, Zuzana Gdovinova, Henry Houlden, Mie Rizig, Matej Skorvanek, on behalf of the CEGEMOD consortium   +35 more
wiley   +1 more source

Cognitive Outcome After Deep Brain Stimulation for Refractory Obsessive–Compulsive Disorder: A Systematic Review

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Introduction Deep brain stimulation (DBS) is an effective treatment for refractory obsessive–compulsive disorder (OCD). Neuropsychological assessment contributes to DBS treatment in several ways: it monitors the cognitive safety of the treatment, identifies beneficial or detrimental cognitive side effects and it could aid to explain ...
Tim A. M. Bouwens van der Vlis, Annelien Duits, Mégan M. G. H. van de Veerdonk, Anne E. P. Mulders, Koen R. J. Schruers, Yasin Temel, Linda Ackermans, Albert F. G. Leentjens   +7 more
wiley   +1 more source

Stimulation sites in the subthalamic nucleus and clinical improvement in Parkinson's disease: a new approach for active contact localization.

Journal of Neurosurgery, 2016
OBJECTIVE Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is widely used in patients with Parkinson's disease (PD). However, which target area of this region results in the highest antiparkinsonian efficacy is still a matter of debate.
D. García‐García, J. Guridi, J. Toledo, M. Alegre, J. Obeso, M. Rodriguez-Oroz   +5 more
semanticscholar   +1 more source

Metabolic and electrophysiological changes in the basal ganglia of transgenic Huntington's disease rats

Neurobiology of Disease, 2012
Huntington's disease (HD) is characterized by neuronal loss in the striatum, ultimately leading to an ‘imbalance’ in the electrical activity of the basal ganglia-thalamocortical circuits.
Rinske Vlamings, Abdelhamid Benazzouz, Jonathan Chetrit, Marcus L.F. Janssen, Ramazan Kozan, Veerle Visser-Vandewalle, Harry W.M. Steinbusch, Stephan von Hörsten, Yasin Temel   +8 more
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