Results 31 to 40 of about 488,438 (323)
Transcriptional Profile of the Developing Subthalamic Nucleus
eneuro, 2022 AbstractThe subthalamic nucleus (STN) is a small, excitatory nucleus that regulates the output of basal ganglia motor circuits. The functions of the STN and its role in the pathophysiology of Parkinson’s disease are now well established. However, some basic characteristics like the developmental origin and molecular phenotype of neuronal subpopulations
Ema Bokulić +2 more
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The next step for imaging the subthalamic nucleus [PDF]
Brain, 2016 Sir, We read with interest the recently published study by Accolla and colleagues (2016) on brain networks modulated by subthalamic nucleus deep brain stimulation (DBS; Accolla et al. , 2016). In their study, the authors combined neurophysiological recordings with MRI to obtain much needed, more detailed information on the functional organization of ...
Birte U. Forstmann +5 more
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A role for the subthalamic nucleus in aversive learning
Cell Reports, 2023 The subthalamic nucleus (STN) is critical for behavioral control; its dysregulation consequently correlated with neurological and neuropsychiatric disorders, including Parkinson's disease. Deep brain stimulation (DBS) targeting the STN successfully alleviates parkinsonian motor symptoms. However, low mood and depression are affective side effects.
Serra, Gian Pietro +9 more
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Development of a novel gripping test for the evaluation of the finger fine motor ability in MPTP-treated monkeys [PDF]
Journal of Integrative Neuroscience, 2020 Assessing the finger fine motor ability is extremely important. However, conventional behavioral tests in monkeys are complicated and costly. We attempted to develop a new task to assess the precise finger grip in Parkinson's disease monkeys based on the
Susumu Kobayashi, Tetsuya Asakawa, Takao Nozaki, Kenji Sugiyama, Tetsuro Sameshima, Kazuhiko Kurozumi
doaj +1 more source
Scientific Reports, 2017 We aimed to explore the effects of bilateral subthalamic nucleus stimulation and levodopa on cardiovascular autonomic function in Parkinson’s disease.
Kai Li +6 more
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Translational Psychiatry, 2022 Patients with psychiatric symptoms, such as depression, anxiety, and visual hallucinations, may be at increased risk for adverse effects following deep brain stimulation of the subthalamic nucleus for Parkinson’s disease, but there have been relatively ...
Ian H. Kratter +7 more
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The subcortical cocktail problem; mixed signals from the subthalamic nucleus and substantia nigra.
PLoS ONE, 2015 The subthalamic nucleus and the directly adjacent substantia nigra are small and important structures in the basal ganglia. Functional magnetic resonance imaging studies have shown that the subthalamic nucleus and substantia nigra are selectively ...
Gilles de Hollander +2 more
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Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia [PDF]
PLoS One. 2012; 7(12): e51530, 2012 Neural activity in the brain of parkinsonian patients is characterized by the intermittently synchronized oscillatory dynamics. This imperfect synchronization, observed in the beta frequency band, is believed to be related to the hypokinetic motor symptoms of the disorder. Our study explores potential mechanisms behind this intermittent synchrony.
arxiv +1 more source
BJA Open, 2022 Background: Micro-electrode recordings are often necessary during electrode implantation for deep brain stimulation of the subthalamic nucleus. Dexmedetomidine may be a useful sedative for these procedures, but there is limited information regarding its ...
Corey Amlong +4 more
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Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance
Journal of Neuroscience, 2018 Considerable evidence suggests a role of beta-band oscillations in voluntary movements. However, most of the studies linking beta power to motor performance are based on data averaged across trials that ignore the fast dynamics of oscillatory activity ...
F. Torrecillos +10 more
semanticscholar +1 more source