Results 31 to 40 of about 17,568 (222)

Imaging of the human subthalamic nucleus

, 2021
The human subthalamic nucleus (STN) is a small lens shaped iron rich nucleus, which has gained substantial interest as a target for deep brain stimulation surgery for a variety of movement disorders. The internal anatomy of the human STN has not been fully elucidated, and an intensive debate, discussing the level of overlap between putative limbic ...
Alkemade, A., Forstmann, B.U.
openaire   +3 more sources

Is Deep Brain Stimulation a viable treatment for substance-related addiction? [PDF]

Romanian Journal of Neurology, 2019
For the ability to modulate the activity of dysregulated networks Deep Brain Stimulation (DBS) of areas involved in reward system and motivational states may have a potential application in addiction despite risks associated with its invasiveness.
Giusy Guzzi, Angelo Lavano, Serena Marianna Lavano, Rosa Marotta   +3 more
doaj   +1 more source

Subthalamic Nucleus Subregion Stimulation Modulates Inhibitory Control [PDF]

Cerebral Cortex Communications, 2020
AbstractPatients with Parkinson’s disease (PD) often experience reductions in the proficiency to inhibit actions. The motor symptoms of PD can be effectively treated with deep brain stimulation (DBS) of the subthalamic nucleus (STN), a key structure in the frontal–striatal network that may be directly involved in regulating inhibitory control. However,
van Wouwe, N.C., Neimat, J.S., van den Wildenberg, W.P.M., Hughes, S.B., Lopez, A.M., Phibbs, F.T., Schall, J.D., Rodriguez, W.J., Bradley, E.B., Dawant, B.M., Wylie, S.A.   +10 more
openaire   +3 more sources

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Cortico-basal white matter alterations occurring in Parkinson's disease.

PLoS ONE, 2019
Magnetic resonance imaging studies typically use standard anatomical atlases for identification and analyses of (patho-)physiological effects on specific brain areas; these atlases often fail to incorporate neuroanatomical alterations that may occur with
Bethany R Isaacs, Anne C Trutti, Esther Pelzer, Marc Tittgemeyer, Yasin Temel, Birte U Forstmann, Max C Keuken   +6 more
doaj   +1 more source

The site of stimulation moderates neuropsychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease

NeuroImage: Clinical, 2018
Deep brain stimulation of the subthalamic nucleus for Parkinson's disease is an established advanced therapy that addresses motor symptoms and improves quality of life.
Philip E. Mosley, David Smith, Terry Coyne, Peter Silburn, Michael Breakspear, Alistair Perry   +5 more
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Chaotic desynchronization as the therapeutic mechanism of deep brain stimulation

Frontiers in Systems Neuroscience, 2011
High frequency deep-brain stimulation of the subthalamic nucleus (DBS) relieves many of the symptoms of Parkinson's disease in humans and animal models. Although the treatment has seen widespread use, its therapeutic mechanism remains paradoxical. The
Charles J Wilson, Bryce eBeverlin, Theoden I Netoff   +2 more
doaj   +1 more source

Understanding the Effects of Conductive Polymer Electrode Coating on Recorded Neural Signals

Advanced Healthcare Materials, EarlyView.
Conductive polymer coatings are widely explored to improve the quality of signals recorded with chronically implanted neural electrodes, offering enhanced biocompatibility along with reduced electrode impedance. Combining computational modelling and data from PEDOT:PTS coated and PtIr electrodes in rats, we show that improvements in signal quality with
Karthik Sridhar, Judith Evers, Alexandre Trotier, Manus Biggs, Madeleine M. Lowery   +4 more
wiley   +1 more source

Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice

Nature Communications, 2021
Innate and learned fear can induce rapid changes in body temperature of mammals. The authors identify the posterior subthalamic nucleus as a major thermoregulatory hub that connects the external lateral parabrachial subnucleus to the nucleus of the ...
Can Liu, Chia-Ying Lee, Greg Asher, Liqin Cao, Yuka Terakoshi, Peng Cao, Reiko Kobayakawa, Ko Kobayakawa, Katsuyasu Sakurai, Qinghua Liu   +9 more
doaj   +1 more source