Results 121 to 130 of about 25,546 (199)

Olezarsen in Hypertriglyceridemia With High Cardiac Risk: A GRADE‐Assessed Meta‐Analysis of Randomized Trials With Trial Sequential Evidence

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This meta‐analysis of randomized trials evaluates olezarsen for hypertriglyceridemia in patients at high cardiovascular risk. Olezarsen significantly improved triglycerides and other atherogenic lipid parameters with generally acceptable safety, supporting its potential as a promising adjunct therapy while highlighting the need for larger and longer ...
Ahmed Emara, Ameer Awashra, Heba Aboeldahab, Ahmed Farid Gadelmawla, Hamza A. Abdul‐Hafez, Abdullah M. Alharran, Amal A. Alsubaiei, Muneera Jasim AlRumaihi, Sara Ahmed Albuhmaid, Abdalhakim Shubietah   +9 more
wiley   +1 more source

Diagnostic ability of Peptidase S8 gene in the Arthrodermataceae causing dermatophytoses: A metadata analysis.

PLoS ONE
An unambiguous identification of dermatophytes causing dermatophytoses is necessary for accurate clinical diagnosis and epidemiological implications. In the current taxonomy of the Arthrodermataceae, the etiological agents of dermatophytoses consist of ...
Apoorva R Kenjar, Juliet Roshini Mohan Raj, Banavasi Shanmukha Girisha, Indrani Karunasagar   +3 more
doaj   +1 more source

Small RNA mediated repression of subtilisin production in Bacillus licheniformis

Scientific Reports, 2017
The species Bacillus licheniformis includes important strains that are used in industrial production processes. Currently the physiological model used to adapt these processes is based on the closely related model organism B. subtilis.
Robert Hertel, Sandra Meyerjürgens, Birgit Voigt, Heiko Liesegang, Sonja Volland   +4 more
doaj   +1 more source

Expanding the genotypic spectrum of PCSK1 deficiency: A novel mutation in severe neonatal diarrhea

JPGN Reports, Volume 7, Issue 2, Page 242-246, May 2026.
Abstract Among congenital diarrhea and enteropathies (CODEs), proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency is a rare monogenic disorder, associated with severe neonatal diarrhea and polyendocrinopathies. We report an 18‐day‐old male neonate, born to consanguineous parents, presenting with persistent watery diarrhea, metabolic ...
Eleonora Saraceno, Angelo Corso Faini, Silvia Deaglio, Marianna Pellegrini, Raffaele Buganza, Francesca Giuliani, Pier Luigi Calvo, Michele Pinon   +7 more
wiley   +1 more source

Impact of CYP2C19 Genotype Variants on PCSK9 Inhibitor Efficacy in Lipid‐Lowering Among Patients With Symptomatic Intracranial Atherosclerotic Stenosis

Lipids, Volume 61, Issue 3, Page 319-329, May 2026.
ABSTRACT Ischemic stroke is frequently associated with symptomatic intracranial atherosclerotic stenosis (sICAS), is a leading cause of global disability and mortality. Current guidelines recommend dual antiplatelet and intensive statin therapies. Proprotein convertase subtilisin 9/kexin type 9 (PCSK9) inhibitors have emerged as a potent lipid‐lowering
Chao Zhao, Nuan Wang, Di Shi, Hao Zhou, Dan Chen, Guofang Chen   +5 more
wiley   +1 more source

Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 5, May 2026.
This graphical abstract summarizes how classical and emerging histone posttranslational modifications (PTMs), together with their chromatin regulators (writers, erasers, and readers), govern major pathobiological programs in cardiovascular disease.
Yu Zheng, Yu‐Xuan Gao, Mei‐Xing Guo, Li‐Ting Wang, Xiao‐Wen Zheng, Yi‐Hao Liao, Ya Li, Jun‐Ping Zhu, Jia‐Ming Wei   +8 more
wiley   +1 more source

Energy transfer in nonlinear network models of proteins

, 2009
We investigate how nonlinearity and topological disorder affect the energy relaxation of local kicks in coarse-grained network models of proteins.
Archilla J. F. R., Best R. B. Merchant K. A. Louis J. M. Gopich I. V. Eaton W. A., F. Piazza, Piazza F., Y.-H. Sanejouand   +4 more
core   +3 more sources

The Evolving Therapeutic Landscape of Gallic Acid: A Review of Mechanistic Insights and Clinical Potential

Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.
ABSTRACT Gallic acid (GA), a plant‐derived phenolic compound, is evolving from a general antioxidant into a specific molecular modulator and a functional building block for advanced biomedical materials. This review synthesizes recent insights underpinned by GA's “redox duality”—its capacity to act as either a radical scavenger or a pro‐oxidant.
Woo Hyun Park
wiley   +1 more source

Hydrophobic interactions of a substrate with L193 on the flexible substrate‐binding loop contribute to 3α‐hydroxysteroid dehydrogenase/carbonyl reductase catalytic efficiency

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Flexible loops within enzyme active sites are central to substrate binding, transition‐state stabilization, and catalytic turnover. Hydrophobic interactions modulate ligand recognition and influence protein function. Here, we interrogated loop‐mediated hydrophobic contributions to catalysis in 3α‐hydroxysteroid dehydrogenase/carbonyl reductase
Yan‐Liang Chen, Yun‐Hao Chou, Hwei‐Jen Lee, Tzu‐Pin Wang, Chi‐Ching Hwang   +4 more
wiley   +1 more source

Conkazal‐M1 from the MKAVA family of conotoxins: A dual‐function protease inhibitor and neuroactive peptide

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney, Thomas Lund Koch, Nicklas Lund Ryding, Aymeric Rogalski, Kevin Chase, Matías Leonel Giglio, Samuel S. Espino, Zildjian G. Acyatan, Maren Watkins, Baldomero M. Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +12 more
wiley   +1 more source