Results 131 to 140 of about 25,546 (199)

Preprosubtilisin Carlsberg processing and secretion is blocked after deletion of amino acids 97-101 in the mature part of the enzyme [PDF]

, 1991
During an investigation into the substrate specificity and processing of subtilisin Carlsberg from Bacillus licheniformis, two major independent findings were made: (i) as has been shown previously, a stretch of five amino acids (residues 97-101 of the ...
Goebel, Werner, Gonski, Sigrid, Kreft, Jürgen, Schülein, Ralf   +3 more
core  

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

PCSK9 Inhibitors Reduce Oxidative Stress Biomarkers in Heterozygous Familial Hypercholesterolemia

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, such as alirocumab and evolocumab, effectively reduce LDL‐C levels, improve cardiovascular outcomes, and are well tolerated in the treatment of heterozygous familial hypercholesterolemia (HeFH).
Agnieszka Woźniak‐Szczepocka, Agnieszka Pawlos, Paulina Gorzelak‐Pabiś, Marlena Broncel, Bożena Bukowska, Ewelina Woźniak   +5 more
wiley   +1 more source

Characterization of drought-responsive subtilisin genes in upland rice: the role of OsSub14 in ABA signaling and ROS accumulation

BMC Plant Biology
Background Drought stress presents a significant challenge to rice production, affecting global food security. The protein degradation pathway is vital for regulating plant drought stress responses. Subtilisins, a family of serine proteases, are known to
Yifan Wang, Fang Chen, Wencong Jin, Xiaorong Xiao, Zhixin Xiang, Qiaoyu Tang, Zhi Hou, Yifeng Zhou, Yanke Lu   +8 more
doaj   +1 more source

Autoactive MtDMI1 Reprogrammes Immunity and Development in Tomato via Ethylene Signalling

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2861-2875, May 2026.
ABSTRACT The Common Symbiosis Signalling Pathway (CSSP) underpins interactions between plants and microbes, yet its potential for crop improvement remains underexplored. Here, we investigated the gain‐of‐function mutant SPD1 (MtDMI1S760N), which constitutively activates the symbiotic signalling pathway in Medicago truncatula, by expressing it in tomato
Haiyue Liu, Ji Xu, Fang Xie
wiley   +1 more source

Processing and release of endogenous immunogenic peptide signals

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY In both animals and plants, small secreted peptides known as cytokines and phytocytokines mediate local and systemic communication during immune and stress responses. These signaling molecules are typically synthesized as inactive precursors that require proteolytic processing to become active.
Maurice Koenig, Hermanyanto Laia, Gunther Doehlemann, Johana C. Misas Villamil   +3 more
wiley   +1 more source

Safety evaluation of the food enzyme glutaminase from the genetically modified Bacillus subtilis strain Glu3‐3

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract The food enzyme glutaminase (l‐glutamine amidohydrolase; EC 3.5.1.2) is produced with the genetically modified Bacillus subtilis strain Glu3‐3 by Angel Yeast Co., Ltd. The production strain of the food enzyme contains multiple copies of acquired antimicrobial resistance genes.
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu   +16 more
wiley   +1 more source

Comprehensive biochemical, molecular and structural characterization of subtilisin with fibrinolytic potential in bioprocessing

Bioresources and Bioprocessing
Enzyme deployment is proliferating extensively in industries owing to their environmentally friendly and easily degradable attributes. This article undertakes an exhaustive examination of wild subtilisin enzyme, covering purification, biochemical ...
Shreya S. Shettar, Zabin K. Bagewadi, Mohammed Alasmary, Basheerahmed Abdulaziz Mannasaheb, Ibrahim Ahmed Shaikh, Aejaz Abdullatif Khan   +5 more
doaj   +1 more source

Safety of oil from Schizochytrium sp. A2 for use in infant and follow‐on formula as a novel food pursuant to regulation (EU) 2015/2283

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of an oil derived from the microalga‐like organism Schizochytrium sp. A2 as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Thomas Frenzel, Margarita Aguilera‐Gómez, Francesca Marcon, Monika Neuhäuser‐Berthold, Irene Nuin Garciarena, Emanuela Turla, Areti Favata, Karen Ildico Hirsch‐Ernst   +22 more
wiley   +1 more source

Spectroscopic methods of studying enzyme action in wool fibre

Open Chemistry, 2006
Fogorasi Magdalena, Heine Elisabeth
doaj   +1 more source