Results 71 to 80 of about 14,250,657 (303)

The Role of Phylogenetics in Unravelling Patterns of HIV Transmission towards Epidemic Control: The Quebec Experience (2002–2020)

Viruses, 2021
Phylogenetics has been advanced as a structural framework to infer evolving trends in the regional spread of HIV-1 and guide public health interventions.
Bluma G. Brenner, Ruxandra-Ilinca Ibanescu, Nathan Osman, Ernesto Cuadra-Foy, Maureen Oliveira, Antoine Chaillon, David Stephens, Isabelle Hardy, Jean-Pierre Routy, Réjean Thomas, Jean-Guy Baril, Roger Leblanc, Cecile Tremblay, Michel Roger, The Montreal Primary HIV Infection (PHI) Cohort Study Group   +14 more
doaj   +1 more source

Comparison of the genotypic and phenotypic properties of HIV-1 standard subtype B and subtype B/B' env molecular clones derived from infections in China. [PDF]

Emerg Microbes Infect, 2018
Although a number of standardized human immunodeficiency virus 1 (HIV-1) pseudoviruses have been generated to assess neutralizing antibodies, subtype B/B' has not been comprehensively characterized either genotypically or phenotypically. Full-length env genes were isolated from plasma samples derived from B/B'-infected individuals, including former ...
Xie H, Nie J, Chen Q, Huang W, Wang Y.
europepmc   +4 more sources

The global spread of HIV-1 subtype B epidemic

Infection, Genetics and Evolution, 2016
Human immunodeficiency virus type 1 (HIV-1) was discovered in the early 1980s when the virus had already established a pandemic. For at least three decades the epidemic in the Western World has been dominated by subtype B infections, as part of a sub-epidemic that traveled from Africa through Haiti to United States.
Magiorkinis, Gkikas, Angelis, Konstantinos, Mamais, Ioannis A., Katzourakis, A., Hatzakis, Angelos E., Albert, Jan, Lawyer, G., Hamouda, O., Struck, D., Vercauteren, J., Wensing, A., Alexiev, Ivailo, Åsjö, Birgitta, Balotta, Claudia, Gomes, P., Camacho, Ricardo J., Coughlan, S., Griskevicius, A., Grossman, Z., Horban, A., Kostrikis, Leontios G., Lepej, S. J., Liitsola, K., Linka, M., Nielsen, C., Otelea, D., Paredes, R., Poljak, M., Puchhammer-Stöckl, E., Schmit, J. C., Sönnerborg, A., Staneková, D., Stanojevic, M., Stylianou, Dora C., Boucher, C. A. B., Nikolopoulos, Georgios K., Vasylyeva, T., Friedman, S. R., van de Vijver, D., Angarano, G., Chaix, M. -L, de Luca, A., Korn, K., Loveday, C., Soriano, V., Yerly, S., Zazzi, M., Vandamme, A. M., Paraskevis, Dimitrios N., Magiorkinis, Gkikas, Angelis, Konstantinos, Mamais, Ioannis A., Katzourakis, A., Hatzakis, Angelos E., Albert, Jan, Lawyer, G., Hamouda, O., Struck, D., Vercauteren, J., Wensing, A., Alexiev, Ivailo, Åsjö, Birgitta, Balotta, Claudia, Gomes, P., Camacho, Ricardo J., Coughlan, S., Griskevicius, A., Grossman, Z., Horban, A., Kostrikis, Leontios G., Lepej, S. J., Liitsola, K., Linka, M., Nielsen, C., Otelea, D., Paredes, R., Poljak, M., Puchhammer-Stöckl, E., Schmit, J. C., Sönnerborg, A., Staneková, D., Stanojevic, M., Stylianou, Dora C., Boucher, C. A. B., Nikolopoulos, Georgios K., Vasylyeva, T., Friedman, S. R., van de Vijver, D., Angarano, G., Chaix, M. -L, de Luca, A., Korn, K., Loveday, C., Soriano, V., Yerly, S., Zazzi, M., Vandamme, A. M., Paraskevis, Dimitrios N.   +97 more
openaire   +13 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

BEAST of subtype B.

, 2015
Analysis of sequences from patients infected with subtype B (Including 30 reference sequences). Notations as in Fig 2.
Eduardo Shahar (384539), Diana Averbuch (384545), Yonat Shemer Avni (786472), Klaris Riesenberg (384538), Dan Turner (240679), Eynat Kedem (786470), Sara Radian Sade (786473), Valery Istomin (384547), Shirley Girshengorn (786471), Itzchak Levy (364292), Frank Maldarelli (69272), Zipi Kra-Oz (515359), Zehava Grossman (7882), Hila Elinav (515355), Ilan Asher (396203), Zev Sthoeger (384542), Karen Olstein-Pops (515352), Boaz Avidor (384536), Zohar Mor (378648), Wei Shao (182165), Michal Chowers (384546), Shlomo Maayan (384543), Margalit Lorber (786468), Daniel Elbirt (384541), Bat Sheva Gottesman (786469)   +24 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Subtype-Specific Conformational Differences within the V3 Region of Subtype B and Subtype C Human Immunodeficiency Virus Type 1 Env Proteins [PDF]

, 2008
The V3 region of the human immunodeficiency virus type 1 gp120 Env protein is a key domain in Env due to its role in interacting with the coreceptors CCR5 and CXCR4.
Noah G. Hoffman, Milloni B. Patel, Hoffman, N. G., Ronald Swanstrom, Patel, M. B., Swanstrom, R.   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Characterisation of subtype C HIV-I envelope glycoproteins and their recognition by llama antibody fragments [PDF]

, 2009
Subtype C HIV-1 is currently responsible for the majority of new infections in the world, particularly in parts of Africa where the adult prevalence rate is as high as 15%.
Koh, W.W.-L.
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source