Results 81 to 90 of about 14,250,657 (303)

Seroconverter HIV subtype B envelope sequences

, 2017
Pre-seroconverter subtype B envelope sequences for 5 individuals.
Anthony D. Kelleher (8136120), Kelleher, Anthony D., Mota, Talia, Suzuki, Kazuo, Stephen Maher (3740062), John M. Murray (150672), Talia Mota (3477083), Maher, Stephen, Kazuo Suzuki (230147), Center, Rob J., Purcell, Damian, Rob J. Center (7288781), Murray, John M., Damian Purcell (3740065)   +13 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Subtype B classification using the improved method.

, 2012
(a) Distribution of Z-scores for group M sequences; (b) Frequency distribution of Z-scores, when six sequences of subtype B are used in the positive training set.
Sanjiv K. Dwivedi (163642), Supratim Sengupta (163647)   +1 more
core   +1 more source

Reservoir differences across HIV-1 subtypes: a systematic review to guide cure research

Frontiers in Immunology
IntroductionDespite effective antiretroviral therapy, HIV-1 persists as a viral reservoir and remains a major barrier to a durable cure. Reservoir size and dynamics are central determinants of the success of cure strategies.
Myrthe S. Willemsen, Myrthe S. Willemsen, Anniek A. N. Tanja, Sody Munsaka, Damalie Nakanjako, Damalie Nakanjako, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Maria A. Papathanasopoulos, Kevin Jenniskens, Kevin Jenniskens, Giulia Sinatti, Giulia Sinatti, Jori Symons, Annemarie M. J. Wensing, Monique Nijhuis, Monique Nijhuis, Ganna Rozhnova, Ganna Rozhnova, Ganna Rozhnova, Ganna Rozhnova   +22 more
doaj   +1 more source

Role of HIV-1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T-lymphocytes and monocyte-derived macrophages

Virology Journal, 2007
Background Several subtypes of HIV-1 circulate in infected people worldwide, including subtype B in the United States and subtype C in Africa and India.
Gopalan Sarla, Sehgal Shobha, Ramakrishnan Rajesh, Das Suman R, Sundaravaradan Vasudha, Ahmad Nafees, Jameel Shahid   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Prevalence of HIV-1 subtype B in Europe.

, 2022
Data from different regions in Europe show substantially higher subtype B percentage prevalence in MSM than HET (P n) are in parantheses. (PDF)
Ananthu James (12225001), Narendra M. Dixit (7478642)   +1 more
core   +1 more source

The role of early cytotoxic lymphocyte (CTL) escape in the pathogenesis of HIV-1 subtype C infection [PDF]

, 2012
Includes abstract.Includes bibliographical references.This study investigated the frequency and timing of cytotoxic T-lympthocyte (CTL) escape and its pathogenic consequences on HIV-1 subtype C disease ...
Ntale, Roman Saba
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source