Results 121 to 130 of about 962,073 (315)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Global Prevalence and Subtype Distribution of Blastocystis sp. in Rodent Populations: A Systematic Review and Meta‐Analysis

Veterinary Medicine and Science
Background The present systematic review and meta‐analysis aimed to gather and analyse global data on the prevalence, subtypes (STs) distribution and zoonotic potential of Blastocystis sp. in rodents.
Amir Farzam, Amin Karampour, Seyedeh‐Sara Nazem‐Sadati, Parisa Sadat‐Madani, Ali Asghari   +4 more
doaj   +1 more source

A Coalgebraic Semantics of Subtyping [PDF]

Electronic Notes in Theoretical Computer Science, 2000
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +4 more sources

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Intrinsic breast cancer subtypes.

, 2014
Serous ovarian tumors in the study cohort with corresponding intrinsic breast cancer subtypes [22]. The rows outline the tumor types with the representation in each subtype in percent within parentheses.
Ida Johansson (241280), Susanne Malander (630329), Mef Nilbert (62211), Anna Måsbäck (630328), Jenny-Maria Jönsson (630324), Mev Dominguez-Valentin (444687), Mats Jönsson (444689), Jesper Hansen Bonde (630326), Päivi Kannisto (630327), Siker Kimbung (630325), Ingrid Hedenfalk (75489)   +10 more
core   +1 more source

Adverse pregnancy outcomes in hypertensive disorders of pregnancy: an in-depth comparison between subtypes

Frontiers in Medicine
ObjectiveTo compare adverse pregnancy outcomes (APOs) between subtypes of hypertensive disorders of pregnancy (HDP).MethodsData were obtained from the Maternal Near-Miss Surveillance System in Hunan Province, China, 2012–2022.
Xu Zhou, Yinglan Wu, Ting Han, Xiaoying Chen   +3 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Glycometabolic profiles and pregnancy outcomes across pathophysiological subtypes of gestational diabetes mellitus

Frontiers in Endocrinology
BackgroundGestational diabetes mellitus (GDM) exhibits profound pathophysiological heterogeneity, but current management fails to account for subtype-specific differences in clinical features and pregnancy prognoses.
Junyou Su, Jing Luo, Xiaoting Huang, Yan Huang, Sumei Wang   +4 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source