Results 141 to 150 of about 962,073 (315)

PIK3CA mutation subtypes.

, 2013
PIK3CA mutation subtypes.
Melissa C. Southey (89921), Elizabeth J. Williamson (421772), Dallas R. English (89920), Kristy Sanderson (421771), Christophe Rosty (245644), Mark A. Jenkins (108168), Graham G. Giles (89916), Mark Clendenning (245560), Rhiannon J. Walters (245562), Aung Ko Win (245555), Susan Parry (163034), Daniel D. Buchanan (245549), Joanne P. Young (163036), Michael D. Walsh (245558), John L. Hopper (89919)   +14 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Molecular and Biological Subtypes of Breast Cancer [PDF]

Breast cancer is a heterogeneous disease characterized by diverse molecular and biological subtypes, which influence prognosis and treatment strategies. Identification of these subtypes through molecular profiling has significantly improved personalized ...
PhD Orifjon Absamatillaevich Talipov
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Parameter values of WM subtypes.

, 2018
Parameter values of WM subtypes.
Julien Lamy (752482), Mathieu D. Santin (305891), Alexandre Vignaud (622837), Paulo L. de Sousa (445704), Olivier Mainberger (5400644), Mathilde M. Roser (5400641), Jack R. Foucher (5400647)   +6 more
core   +1 more source

Unveiling the Layers of Borderline Personality Disorder: A Systematic Review of Clinical Subtypes

Behavioral Sciences
Background: Borderline personality disorder (BPD) is characterised by significant clinical heterogeneity. Classifying subtypes of BPD may offer deeper insights into the disorder’s complexity and inform more tailored therapeutic strategies.
Alexandra Triantafyllou, Pentagiotissa Stefanatou, George Konstantakopoulos, Eleni Giannoulis, Ioannis Malogiannis   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Principle lung cancer molecular subtypes.

, 2013
Principle lung cancer molecular subtypes.
George R. Simon (331974), Raphael Bueno (111214), Phillip A. Dennis (208430), Ravi Salgia (253953), Smruti J. Vidwans (226338), Nicholas P. Campbell (331972), Gregory A. Otterson (49058), Lisandra West (331971), Jeff Shrager (29857)   +8 more
core   +1 more source

Discovery of an independent poor-prognosis subtype associated with tertiary lymphoid structures in breast cancer

Frontiers in Immunology
IntroductionTertiary lymphoid structures (TLSs) are ectopic lymphoid formations that arise in non-lymphoid tissues due to chronic inflammation. The pivotal function of TLSs in regulating tumor invasion and metastasis has been established across several ...
Ruiqi Liu, Xiaoqian Huang, Shiwei Yang, Wenbo Du, Xiaozhou Chen, Huamei Li   +5 more
doaj   +1 more source