Results 131 to 140 of about 962,073 (315)

A retrospective review of leprosy diagnosed histopathologically from skin biopsy specimens in central South Africa

Southern African Journal of Infectious Diseases
Background: Leprosy, caused by Mycobacterium leprae, remains a condition designated by the World Health Organization (WHO) as a neglected tropical disease, despite formal eradication in South Africa. Histopathology is pivotal in the diagnosis of leprosy,
Ruben B. van Wyk, Danita L. le Grange, Liska Budding   +2 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

MOESM1 of Characterization update of HIV-1 M subtypes diversity and proposal for subtypes A and D sub-subtypes reclassification

, 2018
Additional file 1: Fig. S1. Full genome genetic distance comparisons between HIV-1 subtype A sub-subtypes according to our classification proposal. X-axis scale lines indicate genetic distance thresholds allowing, in our alignment and model conditions ...
Diane Descamps (266281), Benoit Visseaux (288245), Anne-Geneviève Marcelin (247377), Stéphane Hué (193130), Lorenzo Cerutti (13957), Vincent Calvez (243389), Quentin Le Hingrat (5329364), Marine Perrier (1877152), Stefan Emler (6113111), Nathalie Désiré (3370613)   +9 more
core   +1 more source

Patterns of Diversity and Humoral Immunogenicity for HIV-1 Antisense Protein (ASP)

Vaccines
HIV-1 has an antisense gene overlapping env that encodes the ASP protein. ASP functions are still unknown, but it has been associated with gp120 in the viral envelope and membrane of infected cells, making it a potential target for immune response ...
Diogo Gama Caetano, Paloma Napoleão-Pêgo, Larissa Melo Villela, Fernanda Heloise Côrtes, Sandra Wagner Cardoso, Brenda Hoagland, Beatriz Grinsztejn, Valdilea Gonçalves Veloso, Salvatore Giovanni De-Simone, Monick Lindenmeyer Guimarães   +9 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Amplification of specific KIR3DL1 functional subtypes.

, 2014
KIR3DL1 subtypes among unrelated donors were assessed using the multiplex PCR typing method. A panel of DNA representing homozygosity for each subtype or combination of two subtypes, is shown.
Katharine C. Hsu (576497), Jean-Benoît Le Luduec (5659348), Jeanette E. Boudreau (576496)   +2 more
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Predicted signal peptide cleavage sites for all HA subtypes.

, 2014
The N-terminal signal peptide cleavage site of HA was predicted using the signalP[7] for all HA subtypes. Most subtypes are cleaved close to a highly conserved aspartic acid.
David F. Burke (464054), Derek J. Smith (247972)   +1 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source