Results 111 to 120 of about 1,747,151 (350)

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

A Biomimetic Multi-Component Subunit Vaccine via Ratiometric Loading of Hierarchical Hydrogels [PDF]

The development of subunit vaccines that mimic the molecular complexity of attenuated vaccines has been limited by the difficulty in reliably delivering multiple chemically diverse payloads at controllable concentrations.
Tirzah, Abbott, Sijia, Baofu, Simseok, Yuk, Michael, Vincent, Evan, Scott, Sharan, Bobbala, Haoyu, Li, Yang, Li, Hyeohn, Kim, Baofu, Qiao, Fanfan, Du, Yuan, Qian   +11 more
core   +2 more sources

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Efficacy Evaluation of an E2 Subunit Vaccine Against Highly Virulent Classical Swine Fever Virus Strain

Vaccines
Background/Objectives: Classical swine fever (CSF) is listed by the World Organisation for Animal Health as a highly devastating and contagious pig disease, causing severe economic losses to the swine industry.
Yu-Chieh Chen, Chi-Chih Chen, Wen-Bin Chung, Yen-Li Huang, Guan-Ming Ke, Hso-Chi Chaung   +5 more
doaj   +1 more source

A Subunit Vaccine Based on E2 Protein of Atypical Porcine Pestivirus Induces Th2-type Immune Response in Mice

Viruses, 2018
An atypical porcine pestivirus (APPV) causing congenital tremor type A-II in piglets was identified in China in 2016. An increased number of cases of APPV have been reported in various countries all over the world since 2015.
Huawei Zhang, Wei Wen, Genxi Hao, Huanchun Chen, Ping Qian, Xiangmin Li   +5 more
doaj   +1 more source

Rational Design of Zika Virus Subunit Vaccine with Enhanced Efficacy

Journal of Virology, 2019
Viral subunit vaccines generally show low efficacy. In this study, we revealed an intrinsic limitation of subunit vaccine designs: artificially exposed surfaces of subunit vaccines contain epitopes unfavorable for vaccine efficacy.
Wanbo Tai, Jiawei Chen, Guangyu Zhao, Q. Geng, Lei He, Yuehong Chen, Yu-Sen Zhou, Fang Li, L. Du   +8 more
semanticscholar   +1 more source

T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children. [PDF]

, 2011
BACKGROUND: The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against malaria in sub-Saharan Africa.
Osei-Kwakye, Kingsley, Emmanuel Asafo-Adjei, Patrice Dubois, Agbenyega, Tsiri, Janssens, Michel H, Apanga, Stephen, Adjei, George, Daniel Ansong, Dubois, Patrice, Janssens Michel H., Marc J J Lievens, Apanga Stephen, Owusu-Agyei Seth, Dubois Patrice, Greenwood Brian M., Brian M Greenwood, Ansong Daniel, Sylverken, Justice, Joe Cohen, Barbara M. Savarese, Vekemans Johan, Kwadwo O. Boahen, Owusu-Agyei, Seth, Alex Osei-Akoto, Naana A W Brobby, Kayan, Kingsley, Olivier, Aurelie C, Olivier Aurelie C., Owusu, Sandra K, Jongert, Erik, Lievens, Marc JJ, Antwi, Sampson, Owusu Ruth, Kwadwo O Boahen, Kingsley Kayan, Jongert Erik, Naana A. W. Brobby, Dosoo David, Savarese Barbara M., Philippe J. Moris, Kwaku P Asante, Philippe J Moris, Evans Jennifer A., Brian M. Greenwood, Stephen Apanga, Marc J. J. Lievens, Greenwood, Brian M, Michel H Janssens, Savarese, Barbara M, Sandra K. Owusu, Owusu, Ruth, Sandra K Owusu, Cohen Joe, Erik Jongert, George Adjei, Aurelie C. Olivier, Asante Kwaku P., Osei-Akoto Alex, Justice Sylverken, Jennifer A. Evans, Brobby Naana A. W., Agbenyega Tsiri, Moris Philippe J., Boahen, Kwadwo O, Cohen, Joe, Kayan Kingsley, Sampson Antwi, Sambian, David, Asante, Kwaku P, Asafo-Adjei Emmanuel, Sylverken Justice, Ansong, Daniel, Barbara M Savarese, Boahen Kwadwo O., Adjei George, Osei-Kwakye Kingsley, Kingsley Osei-Kwakye, Asafo-Adjei, Emmanuel, David Sambian, Sambian David, Moris, Philippe J, David Dosoo, Ruth Owusu, Kwaku P. Asante, Lievens Marc J. J., Vekemans, Johan, Tsiri Agbenyega, Brobby, Naana AW, Osei-Akoto, Alex, Aurelie C Olivier, Dosoo, David, Jennifer A Evans, Owusu Sandra K., Seth Owusu-Agyei, Michel H. Janssens, Antwi Sampson, Johan Vekemans, Evans, Jennifer A   +97 more
core   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Preparation and immunological effects of a bivalent subunit candidate vaccine based on the PCV-Cap-2-3 gene engineered from baculovirus

Frontiers in Veterinary Science
IntroductionPorcine circoviruses (PCVs), belonging to the genus Circovirus in the family Circoviridae, are prevalent worldwide and pose a serious threat to the pig industry.
Yi Liu, Yi Liu, Tong Hao, Chengyu Wang, Xiaoxin Chen, Anqi Ju, Jianqiang Liu, Hongtao Wang, Lichun Zhang, Rui Du, Rui Du, Rui Du   +11 more
doaj   +1 more source