Results 131 to 140 of about 1,122,864 (370)

Structural and biophysical analysis of important biomedical enzymes and nano-architectures [PDF]

, 2008
Dopa decarboxylase (DDC) is an important enzyme in the catecholamine biosynthesis pathways. Catecholamines, e.g., dopamine, serotonin, etc. often are the major neuromodulators or neurotransmitters.
Chattopadhyay, Arundhati
core   +1 more source

Identification Epitope on VP4 Protein of Senecavirus A Recognized by a Monoclonal Antibody

Animal Research and One Health, EarlyView.
This study aims to identify conserved antigenic epitopes on the SVA VP4 protein using monoclonal antibodies, providing valuable tools for further exploring its functions and developing detection methods. SVA VP4 protein was expressed in Escherichia coli and purified with High‐Affinity Ni‐Charged Resin FF.
Liang Meng, Xuyan Xiang, Xinyu Qi, Hanrong Zhou, Peiyu Xiao, Fandan Meng, Tongqing An, Haiwei Wang   +7 more
wiley   +1 more source

Differential Immunogenicity and Protective Efficacy Elicited by MTO- and DMT-Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection

Journal of Immunology Research, 2020
Tuberculosis (TB) remains a major and global problem of public health. An effective TB subunit vaccine is urgently needed. Proper selection of the delivery system for the vaccine is crucial for inducing an appropriate immune response tailored to control ...
Nadeem Ullah, Ling Hao, Yaqi Wu, Yandi Zhang, Qing Lei, Jo-Lewis Banga Ndzouboukou, Xiaosong Lin, Xionglin Fan   +7 more
doaj   +1 more source

Interleukin-17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis. [PDF]

, 2017
Tuberculosis (TB) is characterized by extensive pulmonary matrix breakdown. Interleukin-17 (IL-17) is key in host defence in TB but its role in TB-driven tissue damage is unknown.
Aggarwal, Aguilo, Al Shammari, Aujla, Belton, Berg, Bermudez, Brinckerhoff, Chang, Cortez, Dheda, Dhiman, Domingo-Gonzalez, Elkington, Elkington, Elkington, Elkington, Elkington, Elkington, Fossiez, Freches, Fu, Gideon, Gopal, Hamburg, Hamburg, Happel, Hrabec, Huang, Jovanovic, Kubler, Leber, Matthews, Mayer-Barber, McAleer, McAllister, Miossec, Molet, Nuttall, O'Kane, O'Kane, Okamoto Yoshida, Ong, Oriss, Price, Qiao, Qiu, Rivas-Santiago, Ruddy, Sauty, Scriba, Singh, Singh, Sonnenberg, Torrado, Trajkovic, Treadwell, Volkman, Wang, Wickremasinghe, Wickremasinghe, Wong, Wozniak, Wu, Xu, Zijlstra   +65 more
core   +1 more source

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Evaluating the neutralizing ability of a CpG-adjuvanted S-2P subunit vaccine against SARS-CoV-2 Variants of Concern [PDF]

, 2021
Chia-En Lien, Tsun‐Yung Kuo, Yi‐Jiun Lin, Wei‐Cheng Lian, Meei‐Yun Lin, Luke Tzu-Chi Liu, Yu‐Chi Chou, Charles Chen   +7 more
openalex   +1 more source

Rational Design of Zika Virus Subunit Vaccine with Enhanced Efficacy

Journal of Virology, 2019
Viral subunit vaccines generally show low efficacy. In this study, we revealed an intrinsic limitation of subunit vaccine designs: artificially exposed surfaces of subunit vaccines contain epitopes unfavorable for vaccine efficacy.
Wanbo Tai, Jiawei Chen, Guangyu Zhao, Q. Geng, Lei He, Yuehong Chen, Yusen Zhou, Fang Li, L. Du   +8 more
semanticscholar   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Advances in enteric disease vaccines: from innovation to implementation [PDF]

, 2014
The Seventh International Conference on Vaccines for Enteric Diseases Bangkok, Thailand, 6–8 November 2013 Hosting 222 participants from more than 25 countries, the Seventh International Conference on Vaccines for Enteric Diseases (VED 2013) displayed ...
Parker, EPK
core   +1 more source

Multiepitope Subunit Vaccine to Evoke Immune Response against Acute Encephalitis

Journal of Chemical Information and Modeling, 2019
Acute Encephalitis syndrome outbreak has emerged as a major health concern on both national and international scale. The brain inflammation/infections caused by Japanese encephalitis virus (JEV) can lead to death.
Neeraj Kumar, Damini Sood, Neeraj Sharma, R. Chandra   +3 more
semanticscholar   +1 more source