Results 51 to 60 of about 1,122,864 (370)

Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2

Infectious Diseases of Poverty, 2020
Background Coronavirus disease 2019 (COVID-19) linked with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause severe illness and life-threatening pneumonia in humans.
Muhammad Tahir ul Qamar, Farah Shahid, Sadia Aslam, U. Ashfaq, Sidra Aslam, Israr Fatima, Muhammad Mazhar Fareed, A. Zohaib, Lingling Chen   +8 more
semanticscholar   +1 more source

Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

Scientific Reports, 2020
The COVID-19 pandemic is a worldwide health emergency which calls for an unprecedented race for vaccines and treatment. In developing a COVID-19 vaccine, we applied technology previously used for MERS-CoV to produce a prefusion-stabilized SARS-CoV-2 ...
T. Kuo, M. Lin, R. Coffman, J. D. Campbell, P. Traquina, Yi-Jiun Lin, Luke Tzu-Chi Liu, Jinyi Cheng, Yu‐Chi Wu, Chung-Chin Wu, Wei-Hsuan Tang, Chung-Guei Huang, K. Tsao, Charles Chen   +13 more
semanticscholar   +1 more source

Cytokine Profile in Human Peripheral Blood Mononuclear Leukocytes Exposed to Immunoadjuvant and Adjuvant-Free Vaccines Against Influenza

Frontiers in Immunology, 2020
Background: In the last decade, adjuvant-containing vaccines, exerting different effects on the immune system, including the production of cytokines, which are one of the most important regulatory systems of the body, are introduced into practice ...
Mikhail Petrovich Kostinov, Mikhail Petrovich Kostinov, Nelli Kimovna Akhmatova, Ekaterina Alexandrovna Khromova, Aristitsa Mikhailovna Kostinova   +4 more
doaj   +1 more source

Evaluation of classical swine fever E2 (CSF-E2) subunit vaccine efficacy in the prevention of virus transmission and impact of maternal derived antibody interference in field farm applications

Porcine Health Management, 2021
Background Classical swine fever (CSF) is one of the most devastating pig diseases that affect the swine industry worldwide. Besides stamping out policy for eradication, immunization with vaccines of live attenuated CSF or the CSF-E2 subunit is an ...
Jing-Yuan Chen, Chi-Ming Wu, Zeng-Weng Chen, Chih-Ming Liao, Ming-Chung Deng, Min-Yuan Chia, Chienjin Huang, Maw-Sheng Chien   +7 more
doaj   +1 more source

Hemagglutinin sequence conservation guided stem immunogen design from influenza A H3 subtype [PDF]

, 2015
Seasonal epidemics caused by influenza A (H1 and H3 subtypes) and B viruses are a major global health threat. The traditional, trivalent influenza vaccines have limited efficacy because of rapid antigenic evolution of the circulating viruses.
Citron, Michael, Ferrara, Francesca, Flynn, Jessica A, Liang, Xiaoping, Mallajosyula, Vamsee V A, Temperton, Nigel J., Varadarajan, Raghavan   +6 more
core   +4 more sources

Herpes zoster and subunit vaccine

Uirusu, 2021
Varicella-zoster virus (VZV) causes varicella (chickenpox) as primary infection, and latently infects neuronal cells in the dorsal root ganglia (DRG). Reactivation of VZV from DRG results in herpes zoster, often decades later. VZV is the only airborne human herpesvirus and the only herpesvirus whose symptoms (both varicella and herpes zoster) can be ...
openaire   +2 more sources

A novel subunit vaccine based on Fiber1/2 knob domain provides full protection against fowl adenovirus serotype 4 and induces stronger immune responses than a Fiber2 subunit vaccine

Poultry Science
: Outbreaks of hepatitis-hydropericardium syndrome (HHS) caused by fowl adenovirus serotype 4 (FAdV-4) have resulted in huge economic losses to the poultry industry in China since 2015.
Shuaifeng Liu, Xiaofeng Dong, Baishi Lei, Wuchao Zhang, Xiangqin Wang, Wanzhe Yuan, Kuan Zhao   +6 more
doaj   +1 more source

Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults.

New England Journal of Medicine, 2015
BACKGROUND In previous phase 1-2 clinical trials involving older adults, a subunit vaccine containing varicella-zoster virus glycoprotein E and the AS01B adjuvant system (called HZ/su) had a clinically acceptable safety profile and elicited a robust ...
Himal Lal, A. Cunningham, O. Godeaux, R. Chlibek, J. Díez-Domingo, Shinn-Jang Hwang, M. Levin, J. Mcelhaney, A. Põder, J. Puig-Barberá, T. Vesikari, D. Watanabe, L. Weckx, T. Zahaf, T. Heineman   +14 more
semanticscholar   +1 more source

SARS‐CoV‐2 S1 is superior to the RBD as a COVID‐19 subunit vaccine antigen

Journal of Medical Virology, 2020
Since its emergence in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has developed into a global pandemic within a matter of months.
Yunfei Wang, Li-chun Wang, Han Cao, Cunbao Liu   +3 more
semanticscholar   +1 more source

A bivalent subunit bovine herpesvirus 1 vaccine based on the ectodomains of glycoproteins D and B elicits robust protective immunity against infection in a rabbit model

Veterinary Quarterly
Bovine alphaherpesvirus 1 (BoHV-1) is the causative agent of infectious bovine rhinotracheitis and reproductive disorders causing significant economic losses in the cattle industry.
Wenxiao Liu, Chun Yang, Jijing Tian, Jing Cheng, Linyi Zhou, Munir Iqbal, Arslan Mehboob, Rebecca Daines, Sui Zhang, Mengjiao Chen, Xiaoying Wang, Yongqing Li   +11 more
doaj   +1 more source