Results 141 to 150 of about 67,725 (262)

Metabolic Effects of Succinate Dehydrogenase Loss in Cancer. [PDF]

J Cell Physiol
Chatoff A, Kantner DS, Snyder NW, Rink L.   +3 more
europepmc   +1 more source

Adaptation of White Adipocytes to Cooler Temperatures: Impacts on Energy Metabolism and Protein Acetylation

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Cultured white adipocytes exposed to 31°C undergo cell‐autonomous metabolic adaptation characterized by enhanced mitochondrial function and widespread remodeling of the mitochondrial acetylome. Acetyl‐proteomic and metabolomic profiling identified mitochondria‐associated proteins, including SHMT2 and PCCA, whose acetylation changes were linked to ...
Hiroyuki Mori, Hadla Hariri, William Moe, Sophia Durham, Yuridia Guzman, Emma Paulsson, Rachel C. Simmermon, Parth B. Bhanderi, Sydney K. Peterson, Mia J. Dickson, Charles R. Evans, Ormond A. MacDougald   +11 more
wiley   +1 more source

Succinate Dehydrogenase Pathogenic Variants Among Older Adults With Head and Neck Paragangliomas. [PDF]

Laryngoscope Investig Otolaryngol
Bellamkonda N, Naumer A, Buchmann LO, McCrary HC, Espahbodi M, Patel NS.   +5 more
europepmc   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, Volume 600, Issue 15, Page 2094-2107, August 2026.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Functional profiling of somatostatin receptors identifies somatostatin receptor subtype 2 as a vulnerability in Succinate Dehydrogenase SDHB-deficient pheochromocytomas and paragangliomas. [PDF]

Mol Biomed
García-Vioque V, Pedraza-Arevalo S, Moreno-Montilla MT, Rivero-Cortés E, Blázquez-Encinas R, Mangili F, Arroba E, Herrera-Martínez AD, Culler MD, Gálvez-Moreno MÁ, Barlier A, Botella LM, Robledo M, Castaño JP, Ibáñez-Costa A.   +14 more
europepmc   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, Volume 600, Issue 15, Page 2129-2142, August 2026.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

One-Pot Synthesis of Chiral Succinate Dehydrogenase Inhibitors and Antifungal Activity Studies. [PDF]

Adv Sci (Weinh)
Du D, Chen Y, Yang C, Jin Z, Teng H.
europepmc   +1 more source

Mitochondrial Mediated Apoptosis Evaluation of Myristicin on Triple Negative Breast Cancer Model Via Bcl2/Bid Pathway

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Among 15‐20 cases of breast cancer, triple‐negative breast cancer (TNBC) is the deadliest form of the disease. The most effective form of treatment for this type of cancer is still targeted chemotherapy because it lacks hormone receptors. Myristicin, an active aromatic compound with anticancer properties, is mostly found in nutmeg.
Sudhina Sufina Nazar, Aswathy Vadakkumkattle Ajaykumar, Janeesh Plakkal Ayyappan   +2 more
wiley   +1 more source

Correction to "Succinate Dehydrogenase Pathogenic Variants Among Older Adults With Head and Neck Paragangliomas". [PDF]

Laryngoscope Investig Otolaryngol
europepmc   +1 more source

Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer. [PDF]

Cancer Cell Int
Silva L, Skiados N, Murugavel N, Cover K, Luna N, Gupta MK, Contreras SC, O'Brien TE, Zhang WC.   +8 more
europepmc   +1 more source