Results 11 to 20 of about 426,215 (376)

Industrial systems biology of Saccharomyces cerevisiae enables novel succinic acid cell factory. [PDF]

PLoS ONE, 2013
Saccharomyces cerevisiae is the most well characterized eukaryote, the preferred microbial cell factory for the largest industrial biotechnology product (bioethanol), and a robust commerically compatible scaffold to be exploitted for diverse chemical ...
José Manuel Otero, Donatella Cimini, Kiran R Patil, Simon G Poulsen, Lisbeth Olsson, Jens Nielsen   +5 more
doaj   +6 more sources

Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation

bioRxiv, 2021
Robust and effective T cell-mediated immune responses require the proper allocation of metabolic resources to sustain energetically costly processes like growth, proliferation, and cytokine production. Epigenetic control of the genome also governs T cell
Xuyong Chen, Benjamin D. Sunkel, Meng Wang, Siwen Kang, Tingting Wang, J. R. Gnanaprakasam, Lingling Liu, Teresa A. Cassel, D. Scott, Ana M. Muñoz-Cabello, J. López-Barneo, Jun J. Yang, A. Lane, G. Xin, Benjamin Z. Stanton, T. Fan, Ruoning Wang   +16 more
semanticscholar   +1 more source

Succinic Dehydrogenase in Protozoa [PDF]

Nature, 1947
THERE is, as yet, relatively little information about the occurrence of individual enzymes in Protozoa. We have been successful in demonstrating the presence of a succinic dehydrogenase in homogenates of Paramecium caudatum. This has been done using a modified Cartesian diver respirometer of macro dimensions (40–60 µ1. total volume).
Beverley A. Humphrey, George Frederick Humphrey   +1 more
openaire   +3 more sources

Hereditary pheochromocytoma/paraganglioma syndrome with a novel mutation in the succinate dehydrogenase subunit B gene in a Japanese family: two case reports

Journal of Medical Case Reports, 2021
Background Pheochromocytoma and paraganglioma caused by succinate dehydrogenase gene mutations is called hereditary pheochromocytoma/paraganglioma syndrome.
Rei Hirose, Yuya Tsurutani, Chiho Sugisawa, Kosuke Inoue, Sachiko Suematsu, Maki Nagata, Naoki Hasegawa, Yukio Kakuta, Masato Yonamine, Kazuhiro Takekoshi, Noriko Kimura, Jun Saito, Tetsuo Nishikawa   +12 more
doaj   +1 more source

Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance This study demonstrates that underexpression of succinate dehydrogenase (SDH) subunits resulting in accumulation of oncogenic succinate is a common, adverse, epigenetic modulating feature in clear cell renal cell carcinoma (ccRCC), during ...
R. Aggarwal, Rebecca A. Luchtel, V. Machha, Alexander Tischer, Y. Zou, K. Pradhan, Nadia Ashai, N. Ramachandra, J. Albanese, Jung-in Yang, Xiaoyang Wang, Srinivas Aluri, Shanisha A. Gordon, A. Aboumohamed, B. Gartrell, S. Hafizi, J. Pullman, N. Shenoy   +17 more
semanticscholar   +1 more source

TCA cycle tailoring facilitates optimal growth of proton-pumping NADH dehydrogenase-dependent Escherichia coli

Microbiology Spectrum, 2023
The bacterial lifestyle is plastic, requiring transcriptional, translational, and metabolic tailoring for survival. These dynamic cellular processes are energy intensive; therefore, flexible energetics is requisite for adaptive plasticity.
Nikita Goel, Stuti Srivastav, Arjun Patel, Akshay Shirsath, Tushar Ranjan Panda, Malay Patra, Adam M. Feist, Amitesh Anand   +7 more
doaj   +1 more source

Succinate dehydrogenase.

Advances in Enzymology and Related Subjects, 2020
A heterotetrameric enzyme complex found in the inner mitochondrial membrane. This protein complex catalyzes the oxidation of succinate and reduction of ubiquinone and plays a role in both the citric acid cycle and the electron transport chain.
T. Singer, E. Kearney, W. Kenney
semanticscholar   +2 more sources

[Succinate dehydrogenase in cancer].

Medecine sciences : M/S, 2022
Succinate dehydrogenase (SDH) is a mitochondrial enzyme that participates in both the tricarboxylic acid cycle and the electron transport chain. Mutations in genes encoding SDH are responsible for a predisposition to pheochromocytomas and paragangliomas,
Sophie Moog, J. Favier
semanticscholar   +1 more source

Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium

Cell Reports, 2020
Summary: When O2 is plentiful, the mitochondrial electron transport chain uses it as a terminal electron acceptor. However, the mammalian retina thrives in a hypoxic niche in the eye.
Celia M. Bisbach, Daniel T. Hass, Brian M. Robbings, Austin M. Rountree, Martin Sadilek, Ian R. Sweet, James B. Hurley   +6 more
doaj   +1 more source

Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded Rieske FeS cluster

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Targeting energy metabolism in Mycobacterium tuberculosis has emerged as a new paradigm in antituberculosis drug discovery. Succinate dehydrogenase is considered the regulator of respiration in M. tuberculosis.
Xiaoting Zhou, Yan Gao, Weiwei Wang, Xiaolin Yang, Xiuna Yang, Fengjiang Liu, Yanting Tang, S. Lam, G. Shui, Lu Yu, C. Tian, L. Guddat, Quan Wang, Z. Rao, H. Gong   +14 more
semanticscholar   +1 more source