Synthesis, Pharmacokinetic Characterization and Antioxidant Capacity of Carotenoid Succinates and Their Melatonin Conjugates [PDF]
Molecules, 2022 Carotenoid succinates were synthesized from hydroxy carotenoids and were coupled to a commercially available derivative of melatonin via amide bond for producing more powerful anti-oxidants and yet new hybrid lipophilic bifunctional molecules with ...
Dalma Czett +8 more
doaj +2 more sources
Polymorphism and Multi-Component Crystal Formation of GABA and Gabapentin [PDF]
Pharmaceutics, 2023 This study exploits the polymorphism and multi-component crystal formation of γ-amino butanoic acid (GABA) and its pharmaceutically active derivative, gabapentin.
Daniel Komisarek +5 more
doaj +2 more sources
Pathophysiological Aspects of Hyperoxia in Anesthesiologist-Reanimatologist's Practice [PDF]
Общая реаниматология, 2017 The aim of the review is to present potentially negative effects of hyperoxia in various groups of critically ill patients, including those after cardiac arrest, brain injury or stroke, and in cases of sepsis.
Vladimir T. Dolgikh +5 more
doaj +3 more sources
Role of Succinates in Critical Conditions [PDF]
Общая реаниматология, 2014 The literature review reflects the present view of pathological mechanisms for mitochondrial dysfunction in hypoxia during critical conditions. It notes the role of succinates in the development of mitochondrial dysfunction, further organdisorders, and ...
Yu. P. Orlov, N. V. Govorova
doaj +3 more sources
Bis(2-hydroxyethyl) 2-phenylsuccinate [PDF]
Molbank, 2022 Succinic acid esters are important compounds that find many applications in various industrial fields. One of the most promising and easy ways of producing these molecules is represented by the bis-alkoxycarbonylation reaction of olefins.
Diego Olivieri +2 more
doaj +3 more sources
Upcycling poly(succinates) with amines to N-substituted succinimides over succinimide anion-based ionic liquids [PDF]
Nature CommunicationsThe chemical transformation of waste polymers into value-added chemicals is of significance for circular economy and sustainable development. Herein, we report upcycling poly(succinates) (PSS) with amines into N-substituted succinimides over succinimide ...
Fengtian Wu +12 more
doaj +2 more sources
Gemigliptin Alleviates Succinate-Induced Hepatic Stellate Cell Activation by Ameliorating Mitochondrial Dysfunction [PDF]
Endocrinology and Metabolism, 2022 Background Dipeptidyl peptidase-4 inhibitors (DPP-4Is) are used clinically as oral antidiabetic agents. Although DPP-4Is are known to ameliorate liver fibrosis, the protective mechanism of DPP-4Is in liver fibrosis remains obscure.
Giang Nguyen +4 more
doaj +1 more source
Tetrahedron Chem, 2022 Succinates play a vital role in industry, pharmaceutics, beverage, and cosmetics. A regio- and stereoselective alkoxycarbonylation of unsymmetrical internal alkynes with alcohols or phenols toward α, β-unsaturated succinates enabled by palladium ...
Chang-Sheng Kuai +3 more
doaj +1 more source
Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations [PDF]
Endocrinology and Metabolism, 2020 Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate's pro-inflammatory ...
Yuqi Guo +3 more
doaj +1 more source
The Prospects of Succinates’ Use under Hypoxic Conditions in COVID-19
Антибиотики и Химиотерапия, 2021 The aim of the work was the search for materials from experimental and clinical studies reflecting the pathogenetic role of the possible use of succinates for the correction of hypoxia in COVID-19. Materials and methods.
Yu. Р. Orlov +2 more
doaj +1 more source