Results 121 to 130 of about 2,827 (245)

The Addition of Dialkyl Phosphites and Diphenylphosphine Oxide on the Triple Bond of Dimethyl Acetylenedicarboxylate under Solvent-Free and Microwave Conditions

, 2014
The addition of dialkyl phosphites or diphenylphosphine oxide to the triple bond of dialkyl acetylenedicarboxylate may result in mono- and/or bisadducts.
Drahos, László, Jankowski, Stefan, Huben, Krzysztof, Takács, Judit, Keglevich, György, Bálint, Erika   +5 more
core   +1 more source

Dietary Glutamine Supplementation Alleviated Rumen Epithelium Oxidative Damage and Apoptosis Induced by Feed Restriction via Maintaining Mitochondrial Homeostasis in Female Yaks

Animal Research and One Health, EarlyView.
Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue, Shanpeng Ke, Liyuan Shi, Rui Hu, Zhisheng Wang, Quanhui Peng, Huawei Zou, Jianxin Xiao, Yahui Jiang, Fali Wu, Yiping Tang   +10 more
wiley   +1 more source

Asymmetric C-C bond formation by the mixed oxidative coupling of 1,1 '-bi-2-naphthyl esters

, 2002
Asymmetric C-C bond formation was effected by the oxidative coupling of two different ester enolates using (R)-(+)-1,1'-bi(2-naphthol) as a common tether which served to link together both ester moieties in an asymmetric environment.
MULA MB, PLUMET J., MBA BLAZQUEZ, MIRIAM, CSAKY AG   +3 more
core   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Biventricular Pressure‐Volume Loop Analysis in an LVAD Patient Optimized With Impella RP Flex

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Right ventricular (RV) failure after left ventricular assist device (LVAD) implantation is a serious complication which may necessitate temporary mechanical support in refractory cases. Here we describe a 63‐year‐old man with end‐stage ischemic cardiomyopathy and severe combined pre‐ and post‐capillary pulmonary hypertension who developed ...
Sara S. Inglis, Serena Rahme, Andrew N. Rosenbaum, Atta Behfar   +3 more
wiley   +1 more source

Improving the Mechanical Properties of Biodegradable Polyhydroxyalkanoates via PHA–PHA Block‐Copolymer Synthesis

Chemistry – A European Journal, EarlyView.
Covalent linkage of a highly crystalline PHBV with a ductile P3HB4HB is shown to produce block copolymers with markedly enhanced extensibility and toughness, outperforming equivalent blends. The results demonstrate that polymer architecture, not composition alone, governs mechanical response, offering a route to biodegradable materials that combine ...
Katrin Blandine Kockler, Paul Lant, Steven Pratt, Bronwyn Laycock   +3 more
wiley   +1 more source

A Selectfluor‐based Polonovski Rearrangement Leading to Novel Entities for Synthetic and Medicinal Applications

Chemistry – A European Journal, EarlyView.
Starting from carboxylic acids and Selectfluor‐derivatives, functionalized diazabicyclooctanes can be obtained via a novel Polonovski‐type rearrangement proceeding under mild reaction conditions. Besides their use in organic synthesis the unique structure and reactivity of the rearrangement products enables applications in medicinal chemistry ...
Jakob Kuhn, Susanne Gradl, Vanessa Osterloh, Peter Gmeiner, Harald Hübner, Markus R. Heinrich   +5 more
wiley   +1 more source

Influence of Head‐to‐Tail Cyclization of Lanmodulin‐Inspired Peptides on Lanthanide Affinity and Structure

Chemistry – A European Journal, EarlyView.
The influence of head‐to‐tail cyclization, as well as the effect of ring expansion with an additional glycine on lanmodulin‐inspired peptides on the structure and lanthanide (Ln)‐binding behavior was investigated. While the decrease of structural flexibility can indeed increase the Ln affinity and peptide pre‐organization, it does not lead to an ...
Sophie M. Gutenthaler‐Tietze, Jerome Kretzschmar, Satoru Tsushima, Patrick Weis, Robin Steudtner, Björn Drobot, Lena J. Daumann   +6 more
wiley   +1 more source

Screening of Mono-, Di- and Trivalent Cationic Dopants for the Enhancement of Thermal Behavior, Kinetics, Structural, Morphological, Surface and Magnetic Properties of CoFe₂O₄-SiO₂ Nanocomposites. [PDF]

Int J Mol Sci, 2023
Dippong T, Levei EA, Petean I, Deac IG, Mereu RA, Cadar O.   +5 more
europepmc   +1 more source