Results 111 to 120 of about 2,827 (245)

Three-Component and One-Pot Reaction between Aromatic Oximes and Dialkyl Acetylenedicarboxylates in the presence of Trimethyl Phosphite

, 2011
A three-component reaction between trimethyl phosphite, dialkyl acetylene dicarboxylates and aromatic oximes is described as a simple and efficient route for the synthesis of dialkyl 2-(arylbenzylidene aminooxy)-3-(dimethoxy-phosphoryl) succinates in ...
Fereshteh Taraghi, Nasim Shams, Alireza Hassanabadi, Alimohammad Dehghan, Mohammad Anary-Abbasinejad   +4 more
core   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Automated Bacterial Identification and Morphological Feature Analysis in Low‐Dose Cryo‐EM Using YOLOv11

Advanced Intelligent Discovery, EarlyView.
AI‐based tools enable rapid characterization of bacterial ultrastructure in low‐dose cryogenic transmission electron microscopy. The envelope thickness tool quantifies membrane thickness and anisotropy. The flagella module analyzes filament morphology and detects cell‐flagella contacts.
Sita Sirisha Madugula, Lynnicia N. Massenburg, Spenser R. Brown, Amber N. Bible, Chanda R. Harris, Lance X. Zhang, Kiara Parker, Scott T. Retterer, Jennifer L. Morrell‐Falvey, Rama K. Vasudevan, Alexis N. Williams   +10 more
wiley   +1 more source

An Efficient Method for Synthesis of Succinate-Based MMP Inhibitors

, 2016
A differentially protected fumarate undergoes radical addition followed by allylstannane trapping to provide disubstituted succinates in good yields and high anti diastereoselectivity.
Mukund P. Sibi (1633159), Hikaru Hasegawa (3065793)   +1 more
core   +1 more source

Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome

Annals of Neurology, EarlyView.
Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca, Adrià Vilaseca‐Capel, Judith Cantó‐Santos, Ester Tobías, Félix Andújar‐Sánchez, Laia Farré‐Tarrats, Frederic Tort, Carles Rentero, Carlos Enrich, Virginia López, Juan R. Tejedor, Anna Esteve‐Codina, Cristina Núñez de Arenas, Pedro J. Moreno‐Lozano, José C. Milisenda, Mar O'Callaghan, Teresa García‐Silva, Montserrat Morales‐Conejo, Mario F. Fraga, Rafael Artuch, Miguel Á. Martín, José M. Cuezva, Ana Matas, Glòria Garrabou, Mariona Guitart‐Mampel   +24 more
wiley   +1 more source

Synthesis and biological evaluation of mixed aryl-alkyl succinates as modulators of autophagy and apoptosis in gastric carcinoma

: Vitamin E succinate and its derivatives have demonstrated encouraging cytotoxic potential in preclinical models of gastric cancer, paving the way for a novel class of therapeutics.
Battistelli, Michela, Bottegoni, Giovanni, Micucci, Matteo, Onesimo, Francesco, Retini, Michele, Olivieri, Diego, Burattini, Sabrina, Salucci, Sara, Annous, Nour, Mari, Michele, Faenza, Irene, Osman, Riham, Carfagna, Carla, Gianfanti, Federico, Versari, Ilaria   +14 more
core   +1 more source

Microwave-Assisted Homogeneous Acid Catalysis and Chemoenzymatic Synthesis of Dialkyl Succinate in a Flow Reactor

, 2019
International audienceTwo new continuous flow systems for the production of dialkyl succinates were developed via the esterification of succinic acid, and via the trans-esterification of dimethyl succinate.
Christophe Len, Daviot, Laura, Thomas Len, Laura Daviot, Len, Christophe, Carol Sze Ki Lin, Len, Thomas, Sze Ki Lin, Carol   +7 more
core   +1 more source

The Effect of Hydrothermal and Non‐Hydrothermal Synthesis on the Formation of Holmium(III) Succinate Hydrate Frameworks

, 2007
Two novel hydrated holmium(III) succinates with formula [Ho2(C4H4O4)3(H2O)4]·6H2O (1) and [Ho2(C4H4O4)3(H2O)2]·H2O (2) have been synthesized from aqueous solution under ambient and hydrothermal conditions, respectively.
Pozzi, C., Lehmann, C., Bernini, M., Brusau, E., Narda, G., Echeverria, G., Punte, G.   +6 more
core   +1 more source

Application of Glycerol‐Based Adhesives in the Manufacture of Medium‐Density Particleboards

Journal of Applied Polymer Science, EarlyView.
In this study, glycerol‐ and diacid‐based wood adhesives were synthesized and applied to Pinus elliottii wood residues for the manufacture of medium‐density particleboards (MDP). ABSTRACT In this study, glycerol‐ and diacid‐based adhesives were synthesized and applied in the manufacture of medium‐density particleboards (MDP) using pine wood (Pinus ...
André Higo Azevedo Silva, Lucas Ricardo Fernandes Figueiredo, Eliton Souto de Medeiros   +2 more
wiley   +1 more source

Effects of intermittent exposure to hypobaria and cold on the microarchitecture and morphofunctional profile of rat gastrocnemius muscle

The Anatomical Record, EarlyView.
Abstract Intermittent hypobaric hypoxia (IHH) enhances oxygen transport, muscle metabolism, and cardiovascular health; however, the combined effects of hypobaria and cold are less well understood. Exposure to these stressful environmental factors, even intermittently, can affect skeletal muscle due to its plasticity, thereby altering its metabolic and ...
Garoa Santocildes, Teresa Pagès, Ginés Viscor, Joan Ramon Torrella   +3 more
wiley   +1 more source